PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.

Abstract The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.
PMID
Related Publications

Commercial Honeybush (Cyclopia spp.) Tea Extract Inhibits Osteoclast Formation and Bone Resorption in RAW264.7 Murine Macrophages-An in vitro Study.

Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids.

An in vitro study to determine the effect of Terminalia chebula extract and its formulation on Streptococcus mutans.

Effect of Terminalia chebula extract and chlorhexidine on salivary pH and periodontal health: 2 weeks randomized control trial.

Comparative evaluation of terminalia chebula extract mouthwash and chlorhexidine mouthwash on plaque and gingival inflammation - 4-week randomised control trial.

Authors

Mayor MeshTerms

Periodontal Diseases

Terminalia

Keywords

Dental plaque bacteria (DPB)

Ethanol extract of Terminalia chebula (EETC)

Gingivitis

Inflammation

Lipopolysaccharide (LPS)

Osteoclast

Periodontitis

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28202081
OWN - NLM
STAT- MEDLINE
DA  - 20170216
DCOM- 20170223
LR  - 20170226
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Feb 16
TI  - Use of ethanol extracts of Terminalia chebula to prevent periodontal disease
      induced by dental plaque bacteria.
PG  - 113
LID - 10.1186/s12906-017-1619-1 [doi]
AB  - BACKGROUND: The fruit of the Terminalia chebula tree has been widely used for the
      treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, 
      anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental
      plaque bacteria (DPB) are intimately associated with gingivitis and
      periodontitis. In the quest for materials that will prove useful in the treatment
      and prevention of periodontal disease, we investigated the preventive effects of 
      an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and
      bone resorption. METHODS: The anti-bacterial effect of EETC was analyzed using
      the disc diffusion method. The anti-inflammatory effect of EETC was determined by
      molecular biological analysis of the DPB-mediated culture cells. Prevention of
      osteoclastic bone resorption by EETC was explored using osteoclast formation and 
      pit formation assays. RESULTS: EETC suppressed the growth of oral bacteria and
      reduced the induction of inflammatory cytokines and proteases, abolishing the
      expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the
      DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in
      osteoclast precursors and RANKL expression in osteoblasts, thereby contributing
      to the prevention of bone resorption. CONCLUSIONS: EETC may be a beneficial
      supplement to help prevent DPB-mediated periodontal disease.
FAU - Lee, Jongsung
AU  - Lee J
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon, 164-19,
      Republic of Korea.
FAU - Nho, Youn Hwa
AU  - Nho YH
AD  - COSMAX R&I Center, COSMAX Inc., Seongnam, 134-86, Republic of Korea.
FAU - Yun, Seok Kyun
AU  - Yun SK
AD  - COSMAX R&I Center, COSMAX Inc., Seongnam, 134-86, Republic of Korea.
FAU - Hwang, Young Sun
AU  - Hwang YS
AD  - Department of Dental Hygiene, College of Health Science, Eulji University, 553,
      Sansung-Daero, Soojung-Gu, Seongnam City, Republic of Korea. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170216
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (RANK Ligand)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology/therapeutic use
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - Bacteria/*drug effects/growth & development
MH  - Bone Resorption/microbiology/prevention & control
MH  - Cyclooxygenase 2/metabolism
MH  - Cytokines/metabolism
MH  - Dental Plaque/*microbiology
MH  - Dinoprostone/metabolism
MH  - Gingivitis/microbiology/prevention & control
MH  - Inflammation/microbiology/prevention & control
MH  - Mice
MH  - Mouth/microbiology
MH  - Osteoblasts/drug effects
MH  - Osteoclasts/drug effects
MH  - Peptide Hydrolases/metabolism
MH  - *Periodontal Diseases/microbiology/pathology/prevention & control
MH  - Periodontitis/microbiology/prevention & control
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - RANK Ligand/metabolism
MH  - RAW 264.7 Cells
MH  - *Terminalia
PMC - PMC5312597
OTO - NOTNLM
OT  - Dental plaque bacteria (DPB)
OT  - Ethanol extract of Terminalia chebula (EETC)
OT  - Gingivitis
OT  - Inflammation
OT  - Lipopolysaccharide (LPS)
OT  - Osteoclast
OT  - Periodontitis
EDAT- 2017/02/17 06:00
MHDA- 2017/02/24 06:00
CRDT- 2017/02/17 06:00
PHST- 2016/08/09 [received]
PHST- 2017/02/02 [accepted]
AID - 10.1186/s12906-017-1619-1 [doi]
AID - 10.1186/s12906-017-1619-1 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Feb 16;17(1):113. doi: 10.1186/s12906-017-1619-1.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>