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Disease spectrum of alcoholic liver disease in Beijing 302 Hospital from 2002 to 2013: A large tertiary referral hospital experience from 7422 patients.

Abstract Alcohol consumption in China has substantially increased over the last 3 decades and the number of patients with alcoholic liver disease (ALD) is rising at an alarming rate. However, accurate and representative data on time trends in its hospitalization rates are not available. The aim of this study is to assess the current status and burden of ALD in China by analyzing the data from a large tertiary referral hospital, Beijing 302 Hospital.Data were retrospectively recorded from patients diagnosed as ALD in Beijing 302 Hospital from 2002 to 2013. The disease spectrum and biochemical parameters of each patient were collected.The patients with ALD accounted for 3.93% (7422) of all patients (188,902) with liver diseases between 2002 and 2013. The number of patients hospitalized with ALD increased from 110 in 2002 to 1672 in 2013. The ratio of patients hospitalized with ALD to all patients hospitalized with liver diseases was rising almost continuously and increased from 1.68% in 2002 to 4.59% in 2013. Most patients with ALD were male. Age distribution of ALD hospitalization showed that the highest rate was in 40- to 49-year-old group in subjects. Notably, the annual proportion of severe alcoholic hepatitis (SAH) increased 2.43 times from 2002 to 2013. We found the highest levels of mean corpuscular volume, the aspartate aminotransferase/alanine aminotransferase ratio, total bilirubin, international normalized ratio, and alkaline phosphatase in SAH patients, while serum levels of hemoglobin, albumin, and cholinesterase were significantly decreased in SAH group. Among these ALD, the SAH patient population has the worst prognosis. Alcoholic cirrhosis (ALC) is the most common ALD, and annual admissions for ALC increased significantly during the analyzed period.The number of hospitalized patients with ALD and the annual hospitalization rate of ALD were increasing continuously in Beijing 302 Hospital from 2002 to 2013. More attention should be paid to develop population-based effective strategy to control ALD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28207552
OWN - NLM
STAT- MEDLINE
DA  - 20170216
DCOM- 20170315
LR  - 20170315
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 7
DP  - 2017 Feb
TI  - Disease spectrum of alcoholic liver disease in Beijing 302 Hospital from 2002 to 
      2013: A large tertiary referral hospital experience from 7422 patients.
PG  - e6163
LID - 10.1097/MD.0000000000006163 [doi]
AB  - Alcohol consumption in China has substantially increased over the last 3 decades 
      and the number of patients with alcoholic liver disease (ALD) is rising at an
      alarming rate. However, accurate and representative data on time trends in its
      hospitalization rates are not available. The aim of this study is to assess the
      current status and burden of ALD in China by analyzing the data from a large
      tertiary referral hospital, Beijing 302 Hospital.Data were retrospectively
      recorded from patients diagnosed as ALD in Beijing 302 Hospital from 2002 to
      2013. The disease spectrum and biochemical parameters of each patient were
      collected.The patients with ALD accounted for 3.93% (7422) of all patients
      (188,902) with liver diseases between 2002 and 2013. The number of patients
      hospitalized with ALD increased from 110 in 2002 to 1672 in 2013. The ratio of
      patients hospitalized with ALD to all patients hospitalized with liver diseases
      was rising almost continuously and increased from 1.68% in 2002 to 4.59% in 2013.
      Most patients with ALD were male. Age distribution of ALD hospitalization showed 
      that the highest rate was in 40- to 49-year-old group in subjects. Notably, the
      annual proportion of severe alcoholic hepatitis (SAH) increased 2.43 times from
      2002 to 2013. We found the highest levels of mean corpuscular volume, the
      aspartate aminotransferase/alanine aminotransferase ratio, total bilirubin,
      international normalized ratio, and alkaline phosphatase in SAH patients, while
      serum levels of hemoglobin, albumin, and cholinesterase were significantly
      decreased in SAH group. Among these ALD, the SAH patient population has the worst
      prognosis. Alcoholic cirrhosis (ALC) is the most common ALD, and annual
      admissions for ALC increased significantly during the analyzed period.The number 
      of hospitalized patients with ALD and the annual hospitalization rate of ALD were
      increasing continuously in Beijing 302 Hospital from 2002 to 2013. More attention
      should be paid to develop population-based effective strategy to control ALD.
FAU - Huang, Ang
AU  - Huang A
AD  - aCenter of Noninfectious Liver Diseases, Beijing 302 Hospital bInstitute of
      Alcoholic Liver Disease, Beijing 302 Hospital, Beijing, China.
FAU - Chang, Binxia
AU  - Chang B
FAU - Sun, Yin
AU  - Sun Y
FAU - Lin, Huiming
AU  - Lin H
FAU - Li, Baosen
AU  - Li B
FAU - Teng, Guangju
AU  - Teng G
FAU - Zou, Zheng-Sheng
AU  - Zou ZS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Alcoholism/complications
MH  - China
MH  - Female
MH  - Hepatitis, Alcoholic/epidemiology/physiopathology
MH  - Humans
MH  - Liver Cirrhosis, Alcoholic/epidemiology/physiopathology
MH  - Liver Diseases, Alcoholic/*epidemiology/etiology/*physiopathology
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Tertiary Care Centers/*statistics & numerical data
PMC - PMC5319541
EDAT- 2017/02/17 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/02/17 06:00
AID - 10.1097/MD.0000000000006163 [doi]
AID - 00005792-201702170-00056 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Feb;96(7):e6163. doi: 10.1097/MD.0000000000006163.

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