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Benzodiazepine and "Z-Drug" Dependence: Data From a Tertiary Care Center.

Abstract To examine the clinical characteristics and course of benzodiazepine and �Z-drug� dependence in patients presenting to a tertiary deaddiction center in southern India.
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Journal Title the primary care companion for cns disorders
Publication Year Start




PMID- 28207998
OWN - NLM
STAT- In-Process
DA  - 20170216
LR  - 20170216
IS  - 2155-7780 (Electronic)
IS  - 2155-7780 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Feb 16
TI  - Benzodiazepine and "Z-Drug" Dependence: Data From a Tertiary Care Center.
LID - 10.4088/PCC.16br02025 [doi]
AB  - Objective: To examine the clinical characteristics and course of benzodiazepine
      and Z-drug dependence in patients presenting to a tertiary deaddiction center in 
      southern India. Methods: Case files of 950 inpatients admitted between January
      2007 and January 2014 who reported benzodiazepine or Z-drug use were reviewed.
      Patients (n = 170) with an ICD-10 diagnosis of mental and behavioral disorders
      due to the use of sedatives or hypnotics-dependence syndrome currently using
      substance (F13.24) were included in this study. Results: Alprazolam (n = 86,
      50.6%), nitrazepam (n = 40, 23.5%), and zolpidem (n = 19, 11.2%) were the most
      commonly reported drugs of abuse. Alcohol dependence was present in 37 subjects
      (21.8%) and opioid dependence in 41 subjects (24.1%). Comorbid psychiatric
      illness was diagnosed in 67 patients (39.0%). Only 28 patients (16.5%) had
      sedative dependence with no other substance use disorder. Conclusion: High
      comorbidity occurs in this group of patients. Outcome varies significantly (P <
      .05) between sedative-dependent only and multiple-substancedependent patients.
      High attrition should be addressed through follow-up and tracking mechanisms.
FAU - Shukla, Lekhansh
AU  - Shukla L
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Hosur Rd, Bangalore, Karnataka 560029, India.
      [email protected]
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Bokka, Spandana
AU  - Bokka S
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Shukla, Tulika
AU  - Shukla T
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Kandasamy, Arun
AU  - Kandasamy A
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Chand, Prabhat
AU  - Chand P
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Benegal, Vivek
AU  - Benegal V
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
FAU - Murthy, Pratima
AU  - Murthy P
AD  - Centre for Addiction Medicine, Department of Psychiatry, National Institute of
      Mental Health and Neurosciences, Bangalore, India.
LA  - eng
PT  - Journal Article
DEP - 20170216
PL  - United States
TA  - Prim Care Companion CNS Disord
JT  - The primary care companion for CNS disorders
JID - 101547532
EDAT- 2017/02/17 06:00
MHDA- 2017/02/17 06:00
CRDT- 2017/02/17 06:00
PHST- 2016/07/28 [received]
PHST- 2016/12/08 [accepted]
AID - 10.4088/PCC.16br02025 [doi]
PST - epublish
SO  - Prim Care Companion CNS Disord. 2017 Feb 16;19(1). doi: 10.4088/PCC.16br02025.

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