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A prospective observational longitudinal study of new-onset seizures and newly diagnosed epilepsy in dogs.

Abstract Seizures are common in dogs and can be caused by non-epileptic conditions or epilepsy. The clinical course of newly diagnosed epilepsy is sparsely documented. The objective of this study was to prospectively investigate causes for seizures (epileptic and non-epileptic) in a cohort of dogs with new-onset untreated seizures, and for those dogs with newly diagnosed epilepsy to investigate epilepsy type, seizure type and the course of disease over time, including the risk of seizure recurrence. Untreated client-owned dogs experiencing new-onset seizures were prospectively enrolled in a longitudinal observational study including clinical investigations and long-term monitoring at the Copenhagen University Hospital for Companion Animals. A baseline clinical assessment was followed by investigator/owner contact every eight weeks from inclusion to death or end of study. Inclusion of dogs was conducted from November 2010 to September 2012, and the study terminated in June 2014.
PMID
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Authors

Mayor MeshTerms
Keywords

Canine epilepsy

Epilepsy remission

Epileptic seizure recurrence

Idiopathic epilepsy

Non-epileptic seizures

Journal Title bmc veterinary research
Publication Year Start




PMID- 28209153
OWN - NLM
STAT- MEDLINE
DA  - 20170217
DCOM- 20170227
LR  - 20170227
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 13
IP  - 1
DP  - 2017 Feb 16
TI  - A prospective observational longitudinal study of new-onset seizures and newly
      diagnosed epilepsy in dogs.
PG  - 54
LID - 10.1186/s12917-017-0966-y [doi]
AB  - BACKGROUND: Seizures are common in dogs and can be caused by non-epileptic
      conditions or epilepsy. The clinical course of newly diagnosed epilepsy is
      sparsely documented. The objective of this study was to prospectively investigate
      causes for seizures (epileptic and non-epileptic) in a cohort of dogs with
      new-onset untreated seizures, and for those dogs with newly diagnosed epilepsy to
      investigate epilepsy type, seizure type and the course of disease over time,
      including the risk of seizure recurrence. Untreated client-owned dogs
      experiencing new-onset seizures were prospectively enrolled in a longitudinal
      observational study including clinical investigations and long-term monitoring at
      the Copenhagen University Hospital for Companion Animals. A baseline clinical
      assessment was followed by investigator/owner contact every eight weeks from
      inclusion to death or end of study. Inclusion of dogs was conducted from November
      2010 to September 2012, and the study terminated in June 2014. RESULTS: One
      hundred and six dogs were included in the study. Seventy-nine dogs (74.5%) were
      diagnosed with epilepsy: 61 dogs (77.2%) with idiopathic epilepsy, 13 dogs
      (16.5%) with structural epilepsy and five dogs (6.3%) with suspected structural
      epilepsy. A non-epileptic cause for seizures was identified in 13 dogs and
      suspected in 10 dogs. Four dogs in which no cause for seizures was identified
      experienced only one seizure during the study. In dogs with idiopathic epilepsy
      60% had their second epileptic seizure within three months of seizure onset.
      Twenty-six dogs with idiopathic epilepsy (43%) completed the study without
      receiving antiepileptic treatment. The natural course of idiopathic epilepsy
      (uninfluenced by drugs) was illustrated by highly individual and fluctuating
      seizure patterns, including long periods of remission. Cluster seizures motivated
      early treatment. In a few dogs with a high seizure frequency owners declined
      treatment against the investigators advice. CONCLUSIONS: Epilepsy is the most
      likely diagnosis in dogs presenting with new-onset seizures. The course of
      idiopathic epilepsy is highly individual and might not necessarily require
      long-term treatment. This must be considered when advising owners about what to
      expect with regard to treatment and prognosis.
FAU - Fredso, N
AU  - Fredso N
AD  - Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 
      Dyrlaegevej 16, 1870, Frederiksberg C, Denmark. nadiaf@sund.ku.dk.
FAU - Toft, N
AU  - Toft N
AD  - National Veterinary Institute, Section for Epidemiology, Technical University of 
      Denmark, Frederiksberg C, Denmark.
FAU - Sabers, A
AU  - Sabers A
AD  - The Epilepsy Clinic, Department of Neurology, University State Hospital
      (Rigshospitalet), Copenhagen, Denmark.
FAU - Berendt, M
AU  - Berendt M
AD  - Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 
      Dyrlaegevej 16, 1870, Frederiksberg C, Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170216
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/therapeutic use
MH  - Dog Diseases/*diagnosis/drug therapy/etiology
MH  - Dogs
MH  - Epilepsy/diagnosis/drug therapy/etiology/*veterinary
MH  - Female
MH  - Longitudinal Studies
MH  - Male
MH  - Prospective Studies
MH  - Seizures/diagnosis/drug therapy/etiology/*veterinary
PMC - PMC5314480
OTO - NOTNLM
OT  - *Canine epilepsy
OT  - *Epilepsy remission
OT  - *Epileptic seizure recurrence
OT  - *Idiopathic epilepsy
OT  - *Non-epileptic seizures
EDAT- 2017/02/18 06:00
MHDA- 2017/02/28 06:00
CRDT- 2017/02/18 06:00
PHST- 2016/11/04 [received]
PHST- 2017/02/07 [accepted]
AID - 10.1186/s12917-017-0966-y [doi]
AID - 10.1186/s12917-017-0966-y [pii]
PST - epublish
SO  - BMC Vet Res. 2017 Feb 16;13(1):54. doi: 10.1186/s12917-017-0966-y.

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