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Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths.

Abstract Methamphetamine abuse is a worldwide health concern. Methamphetamine causes health hazards in many vital organs. It can cause damage to cardiac tissue via catecholamines release. Methamphetamine related deaths are becoming one of the most important problems in Iran. The purpose of the present study was to determine cardiac pathology in methamphetamine poisoning-related deaths.
PMID
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Authors

Mayor MeshTerms
Keywords

Cardiac histopathology

Forensic medicine

Forensic pathology

Forensic toxicology

Methamphetamine poisoning-related death

Journal Title daru : journal of faculty of pharmacy, tehran university of medical sciences
Publication Year Start




PMID- 28212679
OWN - NLM
STAT- MEDLINE
DA  - 20170218
DCOM- 20170221
LR  - 20170226
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Linking)
VI  - 25
IP  - 1
DP  - 2017 Feb 17
TI  - Histopathological study of cardiac lesions in methamphetamine poisoning-related
      deaths.
PG  - 5
LID - 10.1186/s40199-017-0170-4 [doi]
AB  - BACKGROUND: Methamphetamine abuse is a worldwide health concern. Methamphetamine 
      causes health hazards in many vital organs. It can cause damage to cardiac tissue
      via catecholamines release. Methamphetamine related deaths are becoming one of
      the most important problems in Iran. The purpose of the present study was to
      determine cardiac pathology in methamphetamine poisoning-related deaths. METHODS:
      The study included 100 cases of methamphetamine poisoning-related deaths and 100 
      cases as control group. Toxicology analysis of liver, gastric content, bile,
      urine, blood and vitreous humor were conducted to detect drugs, poisons and
      alcohols using thin layer chromatography, gas chromatography/mass spectrometry,
      and high performance liquid chromatography. Positive toxicology analysis results 
      except for amphetamine and methamphetamine were excluded from the study in order 
      to omit interfering factors. The most striking features of cardiac damage were
      observed by light microscopy. RESULTS: Methamphetamine and amphetamine were
      detected in either urine or gastric content samples. In all of the cases
      methamphetamine toxicity was determined to be a direct cause of death by forensic
      medicine practitioner. Cardiovascular pathology was noted in 68% of studied
      cases. The most common histopathologic features were myocardial fiber
      hypertrophy, mild, moderate to severe atherosclerosis and focal
      degeneration/necrosis. CONCLUSION: The results of the present study indicate that
      cardiotoxicity is one of the major contributing factors in methamphetamine
      poisoning related deaths. Overall, the current study highlights the fact that
      cardiotoxic effects of methamphetamine can explain increasing reports of heart
      failure and consequently death in young abusers. TRIAL REGISTRATION: Not
      applicable. Histopathological study of cardiac lesions in methamphetamine
      poisoning-related deaths.
FAU - Akhgari, Maryam
AU  - Akhgari M
AD  - Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine
      Organization, Old Ghom Road, 500 meters after Beheste Zahra, 1816153141, Tehran, 
      Iran. [email protected]
FAU - Mobaraki, Homeira
AU  - Mobaraki H
AD  - Department of Forensic Pathology, Legal Medicine Research Center, Legal Medicine 
      Organization, Tehran, Iran.
FAU - Etemadi-Aleagha, Afshar
AU  - Etemadi-Aleagha A
AD  - Tehran University of Medical Sciences (TUMS), Amir Alam Hospital, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170217
PL  - England
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Iran/epidemiology
MH  - Methamphetamine/*poisoning
MH  - Myocardium/*pathology
MH  - Substance-Related Disorders/*mortality/pathology
MH  - Young Adult
PMC - PMC5316196
OTO - NOTNLM
OT  - Cardiac histopathology
OT  - Forensic medicine
OT  - Forensic pathology
OT  - Forensic toxicology
OT  - Methamphetamine poisoning-related death
EDAT- 2017/02/19 06:00
MHDA- 2017/02/22 06:00
CRDT- 2017/02/19 06:00
PHST- 2016/10/18 [received]
PHST- 2017/02/07 [accepted]
AID - 10.1186/s40199-017-0170-4 [doi]
AID - 10.1186/s40199-017-0170-4 [pii]
PST - epublish
SO  - Daru. 2017 Feb 17;25(1):5. doi: 10.1186/s40199-017-0170-4.

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