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Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus, Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a retrospective analysis (2013-2015).

Abstract Post-Soviet Kyrgyzstan has experienced a major surge in blood-borne infections, but data from adequately powered, up-to-date studies are lacking. We thus examined a) the seroprevalences of hepatitis B virus surface antigen (HBsAg), HIV-1 p24 antigen and antibodies against hepatitis C virus (anti-HCV), human immunodeficiency viruses (anti-HIV-1/2, HIV-1 group O), and Treponema pallidum among blood donors in Kyrgyzstan and assess their distribution according to sex, age, and provinces of residence; b) trends in the respective seroprevalences; and c) co-infection rates among the pathogens studied.
PMID
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Authors

Mayor MeshTerms

Blood Donors

Keywords

Blood donors

Co-infections

Hepatitis B

Hepatitis C

Human immunodeficiency virus

Kyrgyzstan

Prevalence

T. pallidum

Journal Title infectious diseases of poverty
Publication Year Start




PMID- 28222792
OWN - NLM
STAT- MEDLINE
DA  - 20170222
DCOM- 20170306
LR  - 20170306
IS  - 2049-9957 (Electronic)
IS  - 2049-9957 (Linking)
VI  - 6
IP  - 1
DP  - 2017 Feb 21
TI  - Seroprevalence of hepatitis B, hepatitis C, human immunodeficiency virus,
      Treponema pallidum, and co-infections among blood donors in Kyrgyzstan: a
      retrospective analysis (2013-2015).
PG  - 45
LID - 10.1186/s40249-017-0255-9 [doi]
AB  - BACKGROUND: Post-Soviet Kyrgyzstan has experienced a major surge in blood-borne
      infections, but data from adequately powered, up-to-date studies are lacking. We 
      thus examined a) the seroprevalences of hepatitis B virus surface antigen
      (HBsAg), HIV-1 p24 antigen and antibodies against hepatitis C virus (anti-HCV),
      human immunodeficiency viruses (anti-HIV-1/2, HIV-1 group O), and Treponema
      pallidum among blood donors in Kyrgyzstan and assess their distribution according
      to sex, age, and provinces of residence; b) trends in the respective
      seroprevalences; and c) co-infection rates among the pathogens studied. METHODS: 
      Serological screening was performed on 37 165 blood donors at the Republican
      Blood Centre in Bishkek, Kyrgyzstan, between January 2013 and December 2015. We
      applied poststratification weights to control for sampling bias and used logistic
      regression analyses to examine the association of seropositivity and
      co-infections with sex, age, provinces of residence, and year of blood donation. 
      RESULTS: Twenty nine thousand and one hundred forty-five (78%) donors were males 
      and 8 020 (22%) were females. The median age was 27 years (range: 18 - 64). The
      prevalences of HBsAg, anti-HCV, HIV (p24 Ag and anti-HIV), and anti-T. pallidum
      were 3.6% (95%CI: 3.4 - 3.8%), 3.1% (3.0 - 3.3%), 0.78% (0.69 - 0.87%), and 3.3% 
      (3.1 - 3.5%), respectively. Males were more likely to be seropositive for HBsAg
      than females (OR: 1.63; 95%CI: 1.40 - 1.90), but less likely to be seropositive
      for anti-HCV (0.85; 0.74 - 0.98) and HIV (0.65; 0.49 - 0.85). Prevalences were
      lower in the capital than in the other provinces. There was a decreasing trend in
      the seroprevalences of HBsAg, anti-HCV, and anti-T. pallidum from 2012 to 2015
      (P-value for trend, P = 0.01, P < 0.0001, P < 0.0001, respectively), while the
      seroprevalence of HIV increased (P = 0.049). One hundred eighty donors (0.48%)
      were seropositive for multiple infections. The highest co-infection rate was
      observed between anti-T. pallidum and HBsAg (6.0%), followed by anti-HCV and
      anti-T. pallidum (5.2%), and HIV and anti-HCV (4.9%). CONCLUSIONS: The data
      suggest that Kyrgyzstan can be reclassified from high to lower-intermediate HBsAg
      endemicity, whereas the high HIV prevalence with a rising trend is an alarming
      finding that needs to be urgently addressed by public health authorities. The
      observed co-infections suggest common risk factors but also common preventive
      interventions.
FAU - Karabaev, Bakyt B
AU  - Karabaev BB
AD  - Republican Blood Centre, Bishkek, Kyrgyzstan, Chingiz Aitmatov Ave 60, 720044,
      Bishkek, Kyrgyzstan.
FAU - Beisheeva, Nurgul J
AU  - Beisheeva NJ
AD  - Republican AIDS Centre, Bishkek, Kyrgyzstan, Logvinenko Str. 8, 720040, Bishkek, 
      Kyrgyzstan.
FAU - Satybaldieva, Aiganysh B
AU  - Satybaldieva AB
AD  - Republican Blood Centre, Bishkek, Kyrgyzstan, Chingiz Aitmatov Ave 60, 720044,
      Bishkek, Kyrgyzstan.
FAU - Ismailova, Aikul D
AU  - Ismailova AD
AD  - Republican AIDS Centre, Bishkek, Kyrgyzstan, Logvinenko Str. 8, 720040, Bishkek, 
      Kyrgyzstan.
FAU - Pessler, Frank
AU  - Pessler F
AD  - TWINCORE, Centre for Experimental and Clinical Infection Research,
      Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
AD  - Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig,
      Germany.
AD  - Centre for Individualized Infection Medicine, c/o CRC Hannover, Feodor-Lynen-Str.
      15, 30625, Hannover, Germany.
FAU - Akmatov, Manas K
AU  - Akmatov MK
AD  - TWINCORE, Centre for Experimental and Clinical Infection Research,
      Feodor-Lynen-Str. 7, 30625, Hannover, Germany. manas.akmatov@twincore.de.
AD  - Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig,
      Germany. manas.akmatov@twincore.de.
AD  - Centre for Individualized Infection Medicine, c/o CRC Hannover, Feodor-Lynen-Str.
      15, 30625, Hannover, Germany. manas.akmatov@twincore.de.
LA  - eng
PT  - Journal Article
DEP - 20170221
PL  - England
TA  - Infect Dis Poverty
JT  - Infectious diseases of poverty
JID - 101606645
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (HIV Core Protein p24)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - *Blood Donors
MH  - Coinfection/*epidemiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HIV Core Protein p24/blood
MH  - HIV Infections/*epidemiology/immunology/virology
MH  - HIV Seroprevalence
MH  - HIV-1/immunology
MH  - Hepacivirus/immunology
MH  - Hepatitis B/*epidemiology/immunology/virology
MH  - Hepatitis B Surface Antigens/blood
MH  - Hepatitis B virus/immunology
MH  - Hepatitis C/*epidemiology/immunology/virology
MH  - Hepatitis C Antibodies/blood
MH  - Humans
MH  - Kyrgyzstan/epidemiology
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Seroepidemiologic Studies
MH  - Syphilis/*epidemiology/immunology/microbiology
MH  - Treponema pallidum/immunology
MH  - Young Adult
PMC - PMC5320648
OTO - NOTNLM
OT  - Blood donors
OT  - Co-infections
OT  - Hepatitis B
OT  - Hepatitis C
OT  - Human immunodeficiency virus
OT  - Kyrgyzstan
OT  - Prevalence
OT  - T. pallidum
EDAT- 2017/02/23 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/02/23 06:00
PHST- 2016/06/22 [received]
PHST- 2017/02/07 [accepted]
AID - 10.1186/s40249-017-0255-9 [doi]
AID - 10.1186/s40249-017-0255-9 [pii]
PST - epublish
SO  - Infect Dis Poverty. 2017 Feb 21;6(1):45. doi: 10.1186/s40249-017-0255-9.

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