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Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.

Abstract To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants.The first hypothesis was that unexposed and symptom-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n-butanol exposure.
PMID
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Authors

Mayor MeshTerms

Gene Expression Profiling

Keywords

Chemical exposure

Exposure chamber

Gene expression

Multiple Chemical Sensitivity

qPCR

Journal Title bmj open
Publication Year Start




PMID- 28232466
OWN - NLM
STAT- MEDLINE
DCOM- 20171228
LR  - 20171228
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 7
IP  - 2
DP  - 2017 Feb 22
TI  - Gene expression profiling in persons with multiple chemical sensitivity before
      and after a controlled n-butanol exposure session.
PG  - e013879
LID - 10.1136/bmjopen-2016-013879 [doi]
AB  - OBJECTIVES: To investigate the pathophysiological pathways leading to symptoms
      elicitation in multiple chemical sensitivity (MCS) by comparing gene expression
      in MCS participants and healthy controls before and after a chemical exposure
      optimised to cause symptoms among MCS participants.The first hypothesis was that 
      unexposed and symptom-free MCS participants have similar gene expression patterns
      to controls and a second hypothesis that MCS participants can be separated from
      controls based on differential gene expression upon a controlled n-butanol
      exposure. DESIGN: Participants were exposed to 3.7 ppm n-butanol while seated in 
      a windowed exposure chamber for 60 min. A total of 26 genes involved in
      biochemical pathways found in the literature have been proposed to play a role in
      the pathogenesis of MCS and other functional somatic syndromes were selected.
      Expression levels were compared between MCS and controls before, within 15 min
      after being exposed to and 4 hours after the exposure. SETTINGS: Participants
      suffering from MCS and healthy controls were recruited through advertisement at
      public places and in a local newspaper. PARTICIPANTS: 36 participants who
      considered themselves sensitive were prescreened for eligibility. 18 sensitive
      persons fulfilling the criteria for MCS were enrolled together with 18 healthy
      controls. OUTCOME MEASURES: 17 genes showed sufficient transcriptional level for 
      analysis. Group comparisons were conducted for each gene at the 3 times points
      and for the computed area under the curve (AUC) expression levels. RESULTS: MCS
      participants and controls displayed similar gene expression levels both at
      baseline and after the exposure and the computed AUC values were likewise
      comparable between the 2 groups. The intragroup variation in expression levels
      among MCS participants was noticeably greater than the controls. CONCLUSIONS: MCS
      participants and controls have similar gene expression levels at baseline and it 
      was not possible to separate MCS participants from controls based on gene
      expression measured after the exposure.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Dantoft, Thomas M
AU  - Dantoft TM
AD  - Danish Research Centre for Chemical Sensitivities, Copenhagen University
      Hospital, Gentofte, Denmark.
AD  - Department of Biotechnology and Biomedicine, Technical University of Denmark,
      Lyngby, Denmark.
AD  - Research Centre for Prevention and Health, Copenhagen, Denmark.
FAU - Skovbjerg, Sine
AU  - Skovbjerg S
AD  - Research Centre for Prevention and Health, Copenhagen, Denmark.
FAU - Andersson, Linus
AU  - Andersson L
AD  - Department of Psychology, Umea University, Umea, Sweden.
AD  - Department of Occupational and Public Health Sciences, University of Gavle, Umea,
      Sweden.
FAU - Claeson, Anna-Sara
AU  - Claeson AS
AD  - Department of Psychology, Umea University, Umea, Sweden.
FAU - Engkilde, Kaare
AU  - Engkilde K
AD  - Department of Dermato-Allergology, The National Allergy Research Center,
      Copenhagen University Hospital Gentofte, Denmark.
FAU - Lind, Nina
AU  - Lind N
AD  - Department of Psychology, Umea University, Umea, Sweden.
AD  - Department of Economics, Swedish University of Agricultural Sciences, Uppsala,
      Sweden.
FAU - Nordin, Steven
AU  - Nordin S
AD  - Department of Psychology, Umea University, Umea, Sweden.
FAU - Hellgren, Lars I
AU  - Hellgren LI
AD  - Department of Biotechnology and Biomedicine, Technical University of Denmark,
      Lyngby, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20170222
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 8PJ61P6TS3 (1-Butanol)
SB  - IM
MH  - 1-Butanol/*administration & dosage/adverse effects
MH  - Adult
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Denmark
MH  - Female
MH  - *Gene Expression Profiling
MH  - Humans
MH  - Inhalation Exposure/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Multiple Chemical Sensitivity/*genetics
PMC - PMC5337747
OTO - NOTNLM
OT  - Chemical exposure
OT  - Exposure chamber
OT  - Gene expression
OT  - Multiple Chemical Sensitivity
OT  - qPCR
EDAT- 2017/02/25 06:00
MHDA- 2017/12/29 06:00
CRDT- 2017/02/25 06:00
PHST- 2017/02/25 06:00 [entrez]
PHST- 2017/02/25 06:00 [pubmed]
PHST- 2017/12/29 06:00 [medline]
AID - bmjopen-2016-013879 [pii]
AID - 10.1136/bmjopen-2016-013879 [doi]
PST - epublish
SO  - BMJ Open. 2017 Feb 22;7(2):e013879. doi: 10.1136/bmjopen-2016-013879.