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Comparison of glycemic variability in Japanese patients with type 1 diabetes receiving insulin degludec versus insulin detemir using continuous glucose monitoring: a randomized, cross-over, pilot study.

Abstract To use continuous glucose monitoring (CGM) to compare glycemic variability in patients with type 1 diabetes (T1D) treated with insulin degludec (IDeg) versus insulin detemir (IDet).
PMID
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Comparison of glycemic variability in Japanese patients with type 1 diabetes receiving insulin degludec versus insulin glargine using continuous glucose monitoring: A randomized, cross-over, pilot study.

Authors

Mayor MeshTerms
Keywords

Clinical trial

basal-bolus insulin therapy

continuous glucose monitoring

insulin degludec

insulin detemir

type 1 diabetes

Journal Title expert opinion on pharmacotherapy
Publication Year Start




PMID- 28234565
OWN - NLM
STAT- MEDLINE
DA  - 20170224
DCOM- 20170310
LR  - 20170310
IS  - 1744-7666 (Electronic)
IS  - 1465-6566 (Linking)
VI  - 18
IP  - 4
DP  - 2017 Mar
TI  - Comparison of glycemic variability in Japanese patients with type 1 diabetes
      receiving insulin degludec versus insulin detemir using continuous glucose
      monitoring: a randomized, cross-over, pilot study.
PG  - 335-342
LID - 10.1080/14656566.2017.1293652 [doi]
AB  - OBJECTIVE: To use continuous glucose monitoring (CGM) to compare glycemic
      variability in patients with type 1 diabetes (T1D) treated with insulin degludec 
      (IDeg) versus insulin detemir (IDet). METHODS: Ten patients with T1D were
      randomly assigned to receive once-daily IDeg, followed by twice-daily IDet, or
      vice versa. Glucose variability was evaluated by CGM after >4 weeks of the first 
      insulin and again after crossover to the second insulin. RESULTS: The total daily
      insulin dose (U/kg/day) and the total daily basal insulin dose (U/kg/day) were
      significantly lower during treatment with IDeg than with IDet [median
      (interquartile range): 0.55 (0.54-0.73) vs. 0.64 (0.54-0.83); P = 0.028, 0.24
      (0.19-0.36) vs. 0.30 (0.19-0.39); P = 0.027]. The 24-hour mean glucose levels
      were not significantly different. However, their standard deviation (SD) was
      significantly smaller during treatments with IDeg than those with IDet [59.5
      (39.5-71.0) vs. 72.8 (61.8-92.8); P = 0.008]. Their mean fasting glucose levels
      and the mean postprandial peak levels after breakfast and after dinner were
      significantly lower with IDeg. CONCLUSIONS: A CGM-based comparison demonstrated
      that once-daily IDeg showed fewer glycemic fluctuations than twice-daily IDet.
      IDeg appears to stabilize blood glucose levels better during both daytime and
      nighttime (particularly, before and after breakfast) with a lower insulin dosage.
FAU - Takahashi, Hiroshi
AU  - Takahashi H
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
FAU - Nishimura, Rimei
AU  - Nishimura R
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
AD  - b Graduate School of Public Health , University of Pittsburgh , Pittsburgh , PA ,
      USA.
FAU - Onda, Yoshiko
AU  - Onda Y
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
FAU - Ando, Kiyotaka
AU  - Ando K
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
FAU - Tsujino, Daisuke
AU  - Tsujino D
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
FAU - Utsunomiya, Kazunori
AU  - Utsunomiya K
AD  - a Division of Diabetes, Metabolism and Endocrinology, Department of Internal
      Medicine , Jikei University School of Medicine , Tokyo , Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170222
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin, Long-Acting)
RN  - 4FT78T86XV (Insulin Detemir)
RN  - 54Q18076QB (insulin degludec)
SB  - IM
MH  - Blood Glucose/drug effects
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin Detemir/*therapeutic use
MH  - Insulin, Long-Acting/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Postprandial Period
OTO - NOTNLM
OT  - *Clinical trial
OT  - *basal-bolus insulin therapy
OT  - *continuous glucose monitoring
OT  - *insulin degludec
OT  - *insulin detemir
OT  - *type 1 diabetes
EDAT- 2017/02/25 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/02/25 06:00
AID - 10.1080/14656566.2017.1293652 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2017 Mar;18(4):335-342. doi:
      10.1080/14656566.2017.1293652. Epub 2017 Feb 22.

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