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New Developments in Salivary Gland Pathology: Clinically Useful Ancillary Testing and New Potentially Targetable Molecular Alterations.

Abstract Accurate diagnosis of salivary gland tumors can be challenging because of the many diagnostic entities, the sometimes extensive morphologic overlap, and the rarity of most tumor types. Ancillary testing is beginning to ameliorate some of these challenges through access to newer immunohistochemical stains and fluorescence in situ hybridization probes, which can limit differential diagnostic considerations in some cases. These ancillary testing strategies are especially useful in small biopsy samples, including aspiration cytology. Molecular techniques are also expanding our understanding of salivary gland tumor pathology and are helping to identify potential targets that may improve treatment for some of these tumors. Here, we summarize the clinical use of new immunohistochemical markers in our practice and review the current understanding of chromosomal rearrangements in salivary gland tumor pathology, emphasizing the prospects for exploiting molecular alterations in salivary gland tumors for diagnosis and targeted therapy. We find that immunohistochemistry and fluorescence in situ hybridization are powerful tools toward the diagnosis of salivary gland tumors, especially when used in a systematic manner based on morphologic differential-diagnostic considerations. As new targeted therapies emerge, it will become increasingly vital to incorporate appropriate molecular testing into the pathologic evaluation of salivary gland cancers.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title archives of pathology & laboratory medicine
Publication Year Start




PMID- 28234570
OWN - NLM
STAT- MEDLINE
DA  - 20170224
DCOM- 20170309
LR  - 20170309
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 141
IP  - 3
DP  - 2017 Mar
TI  - New Developments in Salivary Gland Pathology: Clinically Useful Ancillary Testing
      and New Potentially Targetable Molecular Alterations.
PG  - 381-395
LID - 10.5858/arpa.2016-0259-SA [doi]
AB  - Accurate diagnosis of salivary gland tumors can be challenging because of the
      many diagnostic entities, the sometimes extensive morphologic overlap, and the
      rarity of most tumor types. Ancillary testing is beginning to ameliorate some of 
      these challenges through access to newer immunohistochemical stains and
      fluorescence in situ hybridization probes, which can limit differential
      diagnostic considerations in some cases. These ancillary testing strategies are
      especially useful in small biopsy samples, including aspiration cytology.
      Molecular techniques are also expanding our understanding of salivary gland tumor
      pathology and are helping to identify potential targets that may improve
      treatment for some of these tumors. Here, we summarize the clinical use of new
      immunohistochemical markers in our practice and review the current understanding 
      of chromosomal rearrangements in salivary gland tumor pathology, emphasizing the 
      prospects for exploiting molecular alterations in salivary gland tumors for
      diagnosis and targeted therapy. We find that immunohistochemistry and
      fluorescence in situ hybridization are powerful tools toward the diagnosis of
      salivary gland tumors, especially when used in a systematic manner based on
      morphologic differential-diagnostic considerations. As new targeted therapies
      emerge, it will become increasingly vital to incorporate appropriate molecular
      testing into the pathologic evaluation of salivary gland cancers.
FAU - Griffith, Christopher C
AU  - Griffith CC
FAU - Schmitt, Alessandra C
AU  - Schmitt AC
FAU - Little, James L
AU  - Little JL
FAU - Magliocca, Kelly R
AU  - Magliocca KR
AD  - From the Department of Pathology & Laboratory Medicine, Emory University School
      of Medicine, Atlanta, Georgia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
SB  - AIM
SB  - IM
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Salivary Gland Neoplasms/*diagnosis
EDAT- 2017/02/25 06:00
MHDA- 2017/03/10 06:00
CRDT- 2017/02/25 06:00
AID - 10.5858/arpa.2016-0259-SA [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2017 Mar;141(3):381-395. doi: 10.5858/arpa.2016-0259-SA.

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