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Association between circulating transforming growth factor-β1 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis.

Abstract This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-β1 (TGF-β1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-β1 polymorphisms and susceptibility to SLE and RA.  We conducted a meta-analysis on the serum/plasma TGF-β1 levels in SLE and RA patients and healthy controls, and the associations between TGF-β1 +869 T/C, +915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis. Circulating TGF-β1 levels were significantly lower in the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 - -0.070, P = 0.037). Serum/plasma TGF-β1 levels were not significantly different between RA and control groups (SMD = 0.699, 95% CI = -0.379 - 1.717, p = 0.211). No association between TGF-β1 +869 T/C polymorphism and SLE was found. However, meta-analysis showed an association between the TGF-β1 +869 T allele and RA in all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10-4). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9 x 10-4; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However, no association was found between TGF-β1 +915 G/C or -509 C/T polymorphisms and RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-β1 level in SLE patients, and a significant association between TGF-β1 +869 T/C polymorphism and RA development.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title cellular and molecular biology (noisy-le-grand, france)
Publication Year Start




PMID- 28234629
OWN - NLM
STAT- MEDLINE
DA  - 20170224
DCOM- 20170309
LR  - 20170309
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 63
IP  - 1
DP  - 2017 Feb 22
TI  - Association between circulating transforming growth factor-beta1 level and
      polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: A
      meta-analysis.
PG  - 53-59
LID - 10.14715/cmb/2017.63.1.11 [doi]
AB  - This study systemically reviewed evidence regarding the relationship between
      circulating blood transforming growth factor-beta1 (TGF-beta1) levels and
      systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations
      between TGF-beta1 polymorphisms and susceptibility to SLE and RA. We conducted a 
      meta-analysis on the serum/plasma TGF-beta1 levels in SLE and RA patients and
      healthy controls, and the associations between TGF-beta1 +869 T/C, +915 C/G, and 
      -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered
      in this meta-analysis. Circulating TGF-beta1 levels were significantly lower in
      the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 - -0.070, P =
      0.037). Serum/plasma TGF-beta1 levels were not significantly different between RA
      and control groups (SMD = 0.699, 95% CI = -0.379 - 1.717, p = 0.211). No
      association between TGF-beta1 +869 T/C polymorphism and SLE was found. However,
      meta-analysis showed an association between the TGF-beta1 +869 T allele and RA in
      all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10-4). Analysis after
      stratification by ethnicity indicated that the T allele was significantly
      associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9
      x 10-4; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However,
      no association was found between TGF-beta1 +915 G/C or -509 C/T polymorphisms and
      RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-beta1
      level in SLE patients, and a significant association between TGF-beta1 +869 T/C
      polymorphism and RA development.
FAU - Lee, Y H
AU  - Lee YH
AD  - Rheumatology, Korea University Medical Center.
FAU - Bae, S-C
AU  - Bae SC
AD  - Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases,
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170222
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Alleles
MH  - Arabs/genetics
MH  - Arthritis, Rheumatoid/*genetics/pathology
MH  - Asian Continental Ancestry Group/genetics
MH  - Databases, Factual
MH  - European Continental Ancestry Group/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/pathology
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Transforming Growth Factor beta1/*blood/*genetics
EDAT- 2017/02/25 06:00
MHDA- 2017/03/10 06:00
CRDT- 2017/02/25 06:00
PHST- 2016/11/21 [received]
PHST- 2017/02/09 [accepted]
PHST- 2016/12/29 [revised]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2017 Feb 22;63(1):53-59. doi:
      10.14715/cmb/2017.63.1.11.

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