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Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine and Indralin in the Capacity of Radiomitigators.

Abstract The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body (60)Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation. Moreover, summation of the radioprotective and therapeutic effects of the radioprotector was revealed under these conditions. In mice and rats, α1-adrenoreceptor blocker terazosin did not abolish the therapeutic effect of indralin administrated after irradiation, but blocked the radioprotective effect of indralin applied prior to irradiation. At the same time, 5-HT2 serotonin receptor blocker tropoxin abolished the therapeutic effect of indralin without affecting its radioprotective activity.
PMID
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Authors

Mayor MeshTerms

Gamma Rays

Keywords

cystamine

indralin

shielding

terazosin

tropoxin

Journal Title bulletin of experimental biology and medicine
Publication Year Start




PMID- 28239785
OWN - NLM
STAT- MEDLINE
DA  - 20170227
DCOM- 20170315
LR  - 20170315
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 162
IP  - 4
DP  - 2017 Feb
TI  - Pharmacological Analysis of the Therapeutic Effect of Radioprotectors Cystamine
      and Indralin in the Capacity of Radiomitigators.
PG  - 466-469
LID - 10.1007/s10517-017-3641-1 [doi]
AB  - The therapeutic radiomitigating effect of cystamine and indralin was studied in
      experiments on mice and rats and pharmacological analysis of these drugs was
      carried out. The animals were subjected to whole-body 60Co gamma-irradiation. The
      mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an
      interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the
      upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine
      abolished the therapeutic effect of cystamine administered repeatedly every 15
      min over 1 h after irradiation. Moreover, summation of the radioprotective and
      therapeutic effects of the radioprotector was revealed under these conditions. In
      mice and rats, alpha1-adrenoreceptor blocker terazosin did not abolish the
      therapeutic effect of indralin administrated after irradiation, but blocked the
      radioprotective effect of indralin applied prior to irradiation. At the same
      time, 5-HT2 serotonin receptor blocker tropoxin abolished the therapeutic effect 
      of indralin without affecting its radioprotective activity.
FAU - Vasin, M V
AU  - Vasin MV
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia. mikhail-vvasin@yandex.ru.
FAU - Ushakov, I B
AU  - Ushakov IB
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
FAU - Kovtun, V Yu
AU  - Kovtun VY
AD  - Research and Development Center "Farmzaschita", the Federal Medical-Biological
      Agency of Russia, Khimki, Moscow Region, Russia.
FAU - Komarova, S N
AU  - Komarova SN
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
FAU - Semenova, L A
AU  - Semenova LA
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
FAU - Galkin, A A
AU  - Galkin AA
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
FAU - Afanas'ev, R V
AU  - Afanas'ev RV
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
FAU - Bukhtiyarov, I V
AU  - Bukhtiyarov IV
AD  - Research Institute of Occupational Medicine, Russian Academy of Sciences, Moscow,
      Russia.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane)
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Aza Compounds)
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (Phenols)
RN  - 0 (Radiation-Protective Agents)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Receptors, Serotonin, 5-HT2)
RN  - 156799-03-0 (indralin)
RN  - 8B1QWR724A (Reserpine)
RN  - 8L5014XET7 (Terazosin)
RN  - R110LV8L02 (Cystamine)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Adrenergic alpha-1 Receptor Antagonists/pharmacology
MH  - Animals
MH  - Aza Compounds/pharmacology
MH  - Bridged Bicyclo Compounds, Heterocyclic/pharmacology
MH  - Cystamine/antagonists & inhibitors/*pharmacology
MH  - Dose-Response Relationship, Radiation
MH  - Drug Administration Schedule
MH  - Female
MH  - *Gamma Rays
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Phenols/antagonists & inhibitors/*pharmacology
MH  - Prazosin/analogs & derivatives/pharmacology
MH  - Radiation Injuries, Experimental/metabolism/pathology/*prevention & control
MH  - Radiation-Protective Agents/*pharmacology
MH  - Rats
MH  - Receptors, Adrenergic, alpha-1/metabolism
MH  - Receptors, Serotonin, 5-HT2/metabolism
MH  - Reserpine/pharmacology
MH  - Whole-Body Irradiation
OTO - NOTNLM
OT  - cystamine
OT  - indralin
OT  - shielding
OT  - terazosin
OT  - tropoxin
EDAT- 2017/02/28 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/02/28 06:00
PHST- 2016/02/04 [received]
AID - 10.1007/s10517-017-3641-1 [doi]
AID - 10.1007/s10517-017-3641-1 [pii]
PST - ppublish
SO  - Bull Exp Biol Med. 2017 Feb;162(4):466-469. doi: 10.1007/s10517-017-3641-1. Epub 
      2017 Feb 27.

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