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Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy.

Abstract Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca(2+)-ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.
PMID
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Authors

Mayor MeshTerms
Keywords

simvastatin

skeletal muscles

statin-induced myopathy

statins

Journal Title bulletin of experimental biology and medicine
Publication Year Start




PMID- 28239789
OWN - NLM
STAT- MEDLINE
DA  - 20170227
DCOM- 20170315
LR  - 20170315
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 162
IP  - 4
DP  - 2017 Feb
TI  - Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic
      Mechanism of Statin-Induced Myopathy.
PG  - 433-435
LID - 10.1007/s10517-017-3633-1 [doi]
AB  - Administration of simvastatin was followed by a decrease in activities of
      superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested
      to dysfunction of the respiratory chain. The decrease in total ATPase and
      Ca2+-ATPase activities in muscle tissue homogenates reflected impaired transport 
      of active cations essential for muscle contraction. We conclude that abnormal
      relationships in the system of energy synthetic and energy-dependent processes in
      myocytes serve as the molecular basis for the formation of statin-induced
      degenerative changes.
FAU - Mikashinovich, Z I
AU  - Mikashinovich ZI
AD  - Department of General and Clinical Biochemistry No. 1, Rostov State Medical
      University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
FAU - Belousova, E S
AU  - Belousova ES
AD  - Department of Pharmaceutical Chemistry and Pharmacognosy, Rostov State Medical
      University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. 
      [email protected]
FAU - Sarkisyan, O G
AU  - Sarkisyan OG
AD  - Department of General and Clinical Biochemistry No. 1, Rostov State Medical
      University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Anticholesteremic Agents)
RN  - AGG2FN16EV (Simvastatin)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Animals
MH  - Animals, Outbred Strains
MH  - Anticholesteremic Agents/*adverse effects
MH  - Electron Transport/drug effects
MH  - Electron Transport Complex IV/antagonists & inhibitors/metabolism
MH  - Male
MH  - Mitochondria/*drug effects/metabolism
MH  - Muscle Contraction/drug effects/physiology
MH  - Muscle, Skeletal/*drug effects/metabolism
MH  - Muscular Diseases/*chemically induced/metabolism/physiopathology
MH  - Oxidative Phosphorylation/*drug effects
MH  - Rats
MH  - Simvastatin/*adverse effects
MH  - Superoxide Dismutase/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - simvastatin
OT  - skeletal muscles
OT  - statin-induced myopathy
OT  - statins
EDAT- 2017/02/28 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/02/28 06:00
PHST- 2016/03/01 [received]
AID - 10.1007/s10517-017-3633-1 [doi]
AID - 10.1007/s10517-017-3633-1 [pii]
PST - ppublish
SO  - Bull Exp Biol Med. 2017 Feb;162(4):433-435. doi: 10.1007/s10517-017-3633-1. Epub 
      2017 Feb 27.

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