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Antimalarial activity of Garcinia mangostana L rind and its synergistic effect with artemisinin in vitro.

Abstract Malaria especially falciparum malaria still causes high morbidity and mortality in tropical countries. Several factors have been linked to this situation and the most important one is the rapid spread of parasite resistance to the currently available antimalarials, including artemisinin. Artemisinin is the main component of the currently recommended antimalarial, artemisinin based combination therapy (ACT), and it is a free radical generating antimalarial. Garcinia mangostana L (mangosteen) rind contain a lot of xanthone compounds acting as an antioxidant and exhibited antimalarial activity. The aim of this study was to evaluate the antimalarial activity of mangosteen rind extract and its fractions and their interaction with artemisinin against the 3D7 clone of Plasmodium falciparum in vitro.
PMID
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Authors

Mayor MeshTerms
Keywords

Antimalarial

Artemisinin

Garcinia mangostana

Synergism

in vitro

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28241761
OWN - NLM
STAT- MEDLINE
DA  - 20170228
DCOM- 20170317
LR  - 20170317
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Feb 28
TI  - Antimalarial activity of Garcinia mangostana L rind and its synergistic effect
      with artemisinin in vitro.
PG  - 131
LID - 10.1186/s12906-017-1649-8 [doi]
AB  - BACKGROUND: Malaria especially falciparum malaria still causes high morbidity and
      mortality in tropical countries. Several factors have been linked to this
      situation and the most important one is the rapid spread of parasite resistance
      to the currently available antimalarials, including artemisinin. Artemisinin is
      the main component of the currently recommended antimalarial, artemisinin based
      combination therapy (ACT), and it is a free radical generating antimalarial.
      Garcinia mangostana L (mangosteen) rind contain a lot of xanthone compounds
      acting as an antioxidant and exhibited antimalarial activity. The aim of this
      study was to evaluate the antimalarial activity of mangosteen rind extract and
      its fractions and their interaction with artemisinin against the 3D7 clone of
      Plasmodium falciparum in vitro. METHODS: Dry ripe mangosteen rind was extracted
      with ethanol followed by fractionation with hexane, ethylacetate, buthanol, and
      water consecutively to get ethanol extract, hexane, athylacetate, buthanol, and
      water fractions. Each of these substances was diluted in DMSO and examined for
      antimalarial activity either singly or in combination with artemisinin in vitro
      against Plasmodium falciparum 3D7 clone. Synergism between these substances with 
      artemisinin was evaluated according to certain formula to get the sum of
      fractional inhibitory concentration 50 ( summation operatorFIC50). RESULTS:
      Analysis of the parasite growth in vitro indicated that IC50 of these mangosteen 
      rind extract, hexane, ethylacetate, buthanol, and water fraction ranged from 0.41
      to > 100 mug/mL. All of the summation operatorFIC50 were <1. CONCLUSIONS: This
      study demonstrated a promising antimalarial activity of the extract and fractions
      of G.mangostana L rind and its synergistic effect with artemisinin. Further study
      using lead compound(s) isolated from extract and fractions should be performed to
      identify more accurately their mechanism of antimalarial activities.
FAU - Tjahjani, Susy
AU  - Tjahjani S
AD  - Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia.
      susy_tjahjani@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20170228
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 0 (Plant Extracts)
RN  - 0 (Xanthones)
RN  - 9RMU91N5K2 (artemisinine)
SB  - IM
MH  - Antimalarials/*pharmacology
MH  - Artemisinins/*pharmacology
MH  - Drug Synergism
MH  - Fruit/chemistry
MH  - Garcinia mangostana/*chemistry
MH  - In Vitro Techniques
MH  - Inhibitory Concentration 50
MH  - Malaria/*parasitology
MH  - Plant Extracts/*pharmacology
MH  - Plasmodium falciparum/*drug effects/growth & development
MH  - Xanthones/*pharmacology
PMC - PMC5329916
OTO - NOTNLM
OT  - Antimalarial
OT  - Artemisinin
OT  - Garcinia mangostana
OT  - Synergism
OT  - in vitro
EDAT- 2017/03/01 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/01 06:00
PHST- 2016/09/14 [received]
PHST- 2017/02/23 [accepted]
AID - 10.1186/s12906-017-1649-8 [doi]
AID - 10.1186/s12906-017-1649-8 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Feb 28;17(1):131. doi: 10.1186/s12906-017-1649-8.

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