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Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration.

Abstract Purpose. To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD. Methods. MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment. Results. MDA levels in patients with wAMD were significantly greater compared with patients without AMD. In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area. Serum MDA levels decreased in most patients that received supplementation and significantly increased in those who did not. Conclusion. Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area. In addition, nutritional supplementation appeared to exert a protective effect against oxidative stress in patients with wAMD.
PMID
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Authors

Mayor MeshTerms

Dietary Supplements

Keywords
Journal Title oxidative medicine and cellular longevity
Publication Year Start




PMID- 28243361
OWN - NLM
STAT- MEDLINE
DA  - 20170228
DCOM- 20170316
LR  - 20170316
IS  - 1942-0994 (Electronic)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in
      Patients with Wet Age-Related Macular Degeneration.
PG  - 9548767
LID - 10.1155/2017/9548767 [doi]
AB  - Purpose. To compare serum levels of malondialdehyde (MDA) in patients with wet
      age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and
      patients without AMD and to evaluate the efficacy of nutritional supplementation 
      for treating elevated serum MDA in patients with wAMD. Methods. MDA levels were
      measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD.
      Patients with wAMD were randomized to receive or not receive nutritional
      supplementation (10 patients in each group), and MDA levels were measured after 3
      months of treatment. Results. MDA levels in patients with wAMD were significantly
      greater compared with patients without AMD. In eyes with wAMD, there was a
      significant correlation between MDA levels and choroidal neovascularization
      lesion area. Serum MDA levels decreased in most patients that received
      supplementation and significantly increased in those who did not. Conclusion.
      Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels
      were directly correlated with choroidal neovascularization lesion area. In
      addition, nutritional supplementation appeared to exert a protective effect
      against oxidative stress in patients with wAMD.
FAU - Matsuura, Toshiyuki
AU  - Matsuura T
AUID- ORCID: 0000-0003-1803-835X
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Takayama, Kei
AU  - Takayama K
AUID- ORCID: 0000-0002-1477-9014
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Kaneko, Hiroki
AU  - Kaneko H
AUID- ORCID: 0000-0003-0731-6465
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Ye, Fuxiang
AU  - Ye F
AUID- ORCID: 0000-0003-2550-2173
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan; Department of Ophthalmology, Shanghai First People's
      Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240,
      China.
FAU - Fukukita, Hiroshi
AU  - Fukukita H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Tsunekawa, Taichi
AU  - Tsunekawa T
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Kataoka, Keiko
AU  - Kataoka K
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Hwang, Shiang-Jyi
AU  - Hwang SJ
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan; Laboratory of Bell Research Center-Department of
      Obstetrics and Gynecology Collaborative Research, Nagoya University Graduate
      School of Medicine, Nagoya 466-8550, Japan.
FAU - Nagasaka, Yosuke
AU  - Nagasaka Y
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Ito, Yasuki
AU  - Ito Y
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
FAU - Terasaki, Hiroko
AU  - Terasaki H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine,
      Nagoya 466-8550, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Aged
MH  - Choroidal Neovascularization/blood/*diet therapy/pathology
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Macular Degeneration/blood/*diet therapy/pathology
MH  - Male
MH  - Malondialdehyde/*blood
MH  - Wet Macular Degeneration/blood/*diet therapy/pathology
PMC - PMC5294377
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/01 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/01 06:00
PHST- 2016/10/09 [received]
PHST- 2016/12/04 [revised]
PHST- 2016/12/21 [accepted]
AID - 10.1155/2017/9548767 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:9548767. doi: 10.1155/2017/9548767. Epub 2017 Jan
      24.

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