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CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare?

Abstract Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. Methods. Patients with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded. Results. 550 patients were included. MRI revealed CNS metastases in 19 patients (incidence 3.45%), 14 boys, aged 5-22 years. There were 12/250 osteosarcoma cases, 2/200 Ewing's sarcoma, 1/50 chondrosarcoma, 3/49 rhabdomyosarcoma (RMS), and 1/1 malignant mesenchymoma. There were 10 single metastases and 7 cases of multiple ones; in 2 RMS cases only leptomeningeal spread in brain and spinal cord was found. Calcified metastases were found in 3 patients and hemorrhagic in 4. In one RMS patient there were numerous solid, cystic, hemorrhagic lesions and leptomeningeal spread. Conclusions. CNS metastases are rare and late in children with bone/soft tissue sarcomas, although in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous spread to brain and hemorrhagic and calcified lesions dominated in osteosarcoma. Ewing sarcoma tended to metastasize to skull bones. Soft tissue sarcomas presented various morphological forms.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28243595
OWN - NLM
STAT- MEDLINE
DA  - 20170228
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and
      Young Adults: Are They Really So Rare?
PG  - 1456473
LID - 10.1155/2017/1456473 [doi]
AB  - Purpose. To check whether primary involvement of brain/spinal cord by bone/soft
      tissue sarcomas' metastases in children is as rare as described and to present
      various morphological forms of bone/soft tissue sarcomas' CNS metastases.
      Methods. Patients with first diagnosis in 1999-2014 treated at single center were
      included with whole course of disease evaluation. Brain/spinal canal magnetic
      resonance imaging (MRI)/computed tomography were performed in cases suspicious
      for CNS metastases. Extension from skull/vertebral column metastases was
      excluded. Results. 550 patients were included. MRI revealed CNS metastases in 19 
      patients (incidence 3.45%), 14 boys, aged 5-22 years. There were 12/250
      osteosarcoma cases, 2/200 Ewing's sarcoma, 1/50 chondrosarcoma, 3/49
      rhabdomyosarcoma (RMS), and 1/1 malignant mesenchymoma. There were 10 single
      metastases and 7 cases of multiple ones; in 2 RMS cases only leptomeningeal
      spread in brain and spinal cord was found. Calcified metastases were found in 3
      patients and hemorrhagic in 4. In one RMS patient there were numerous solid,
      cystic, hemorrhagic lesions and leptomeningeal spread. Conclusions. CNS
      metastases are rare and late in children with bone/soft tissue sarcomas, although
      in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous 
      spread to brain and hemorrhagic and calcified lesions dominated in osteosarcoma. 
      Ewing sarcoma tended to metastasize to skull bones. Soft tissue sarcomas
      presented various morphological forms.
FAU - Bekiesinska-Figatowska, Monika
AU  - Bekiesinska-Figatowska M
AUID- ORCID: 0000-0003-1787-3425
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Duczkowska, Agnieszka
AU  - Duczkowska A
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Duczkowski, Marek
AU  - Duczkowski M
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Bragoszewska, Hanna
AU  - Bragoszewska H
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Romaniuk-Doroszewska, Anna
AU  - Romaniuk-Doroszewska A
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Iwanowska, Beata
AU  - Iwanowska B
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Szkudlinska-Pawlak, Sylwia
AU  - Szkudlinska-Pawlak S
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Madzik, Jaroslaw
AU  - Madzik J
AD  - Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.
FAU - Bilska, Katarzyna
AU  - Bilska K
AD  - Clinic of Oncological Surgery of Children and Adolescents, Institute of Mother
      and Child, Warsaw, Poland.
FAU - Raciborska, Anna
AU  - Raciborska A
AD  - Clinic of Oncological Surgery of Children and Adolescents, Institute of Mother
      and Child, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Neoplasms/*pathology
MH  - Central Nervous System Neoplasms/*secondary
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Soft Tissue Neoplasms/*pathology
MH  - Young Adult
PMC - PMC5294350
COI - The authors declare no conflict of interests with respect to the manuscript
      authorship and publication. The authors received no financial support for
      preparation of the manuscript.
EDAT- 2017/03/01 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/01 06:00
PHST- 2016/09/20 [received]
PHST- 2016/12/08 [revised]
PHST- 2016/12/15 [accepted]
AID - 10.1155/2017/1456473 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:1456473. doi: 10.1155/2017/1456473. Epub 2017 Jan 24.

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