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Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge.

Abstract Respiratory infection with Bordetella pertussis leads to severe effects in the lungs. The resulting immunity and also immunization with pertussis vaccines protect against disease, but the induced type of immunity and longevity of the response are distinct. In this study the effects of priming, by either vaccination or infection, on a subsequent pathogen encounter were studied. To that end, three postchallenge transcriptome datasets of previously primed mice were combined and compared to the responses in unprimed control mice. In total, 205 genes showed different transcription activity. A coexpression network analysis assembled these genes into 27 clusters, combined into six groups with overlapping biological function. Local pulmonary immunity was only present in mice with infection-induced immunity. Complement-mediated responses were more prominent in mice immunized with an outer membrane vesicle pertussis vaccine than in mice that received a whole-cell pertussis vaccine. Additionally, 46 genes encoding for secreted proteins may serve as markers in blood for the degree of protection (Cxcl9, Gp2, and Pla2g2d), intensity of infection (Retnla, Saa3, Il6, and Il1b), or adaptive recall responses (Ighg, C1qb). The molecular signatures elucidated in this study contribute to better understanding of functional interactions in challenge-induced responses in relation to pertussis immunity.
PMID
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Authors

Mayor MeshTerms

Transcriptome

Keywords
Journal Title journal of immunology research
Publication Year Start




PMID- 28243609
OWN - NLM
STAT- MEDLINE
DA  - 20170228
DCOM- 20170315
LR  - 20170315
IS  - 2314-7156 (Electronic)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies
      Molecular Signatures to Differentiate Immune Responses following Bordetella
      pertussis Challenge.
PG  - 8512847
LID - 10.1155/2017/8512847 [doi]
AB  - Respiratory infection with Bordetella pertussis leads to severe effects in the
      lungs. The resulting immunity and also immunization with pertussis vaccines
      protect against disease, but the induced type of immunity and longevity of the
      response are distinct. In this study the effects of priming, by either
      vaccination or infection, on a subsequent pathogen encounter were studied. To
      that end, three postchallenge transcriptome datasets of previously primed mice
      were combined and compared to the responses in unprimed control mice. In total,
      205 genes showed different transcription activity. A coexpression network
      analysis assembled these genes into 27 clusters, combined into six groups with
      overlapping biological function. Local pulmonary immunity was only present in
      mice with infection-induced immunity. Complement-mediated responses were more
      prominent in mice immunized with an outer membrane vesicle pertussis vaccine than
      in mice that received a whole-cell pertussis vaccine. Additionally, 46 genes
      encoding for secreted proteins may serve as markers in blood for the degree of
      protection (Cxcl9, Gp2, and Pla2g2d), intensity of infection (Retnla, Saa3, Il6, 
      and Il1b), or adaptive recall responses (Ighg, C1qb). The molecular signatures
      elucidated in this study contribute to better understanding of functional
      interactions in challenge-induced responses in relation to pertussis immunity.
FAU - Raeven, Rene H M
AU  - Raeven RH
AUID- ORCID: 0000-0002-1063-271X
AD  - Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands;
      Division of Drug Delivery Technology, Leiden Academic Centre for Drug Research,
      Leiden, Netherlands.
FAU - Pennings, Jeroen L A
AU  - Pennings JL
AUID- ORCID: 0000-0002-9188-6358
AD  - Centre for Health Protection, National Institute for Public Health and the
      Environment, Bilthoven, Netherlands.
FAU - van Riet, Elly
AU  - van Riet E
AD  - Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands.
FAU - Kersten, Gideon F A
AU  - Kersten GF
AD  - Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands;
      Division of Drug Delivery Technology, Leiden Academic Centre for Drug Research,
      Leiden, Netherlands.
FAU - Metz, Bernard
AU  - Metz B
AD  - Institute for Translational Vaccinology (Intravacc), Bilthoven, Netherlands.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170124
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Bacterial Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Pertussis Vaccine)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/blood/*genetics
MH  - Biomarkers/blood
MH  - Bordetella pertussis/*immunology
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Regulatory Networks
MH  - Immunity, Cellular/*genetics
MH  - Immunologic Memory/genetics
MH  - Lung/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pertussis Vaccine/administration & dosage/*immunology
MH  - *Transcriptome
MH  - Vaccination
MH  - Whooping Cough/genetics/*immunology
PMC - PMC5294382
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/01 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/01 06:00
PHST- 2016/06/17 [received]
PHST- 2016/08/16 [revised]
PHST- 2016/12/14 [accepted]
AID - 10.1155/2017/8512847 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:8512847. doi: 10.1155/2017/8512847. Epub 2017 Jan 24.

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