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The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.

Abstract Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of the cortical matter in the thymus decreased 6 months after carcinogenesis induction, the percentage of connective tissue elements and glandular tissue and the counts of immunoblasts and cells with pyknotic nuclei increased, this indicating the development of accidental involution of the thymus. Animals of the experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte migration from the thymus and suppressed activities of the lymphoid and epithelial components (lesser area of connective tissue elements and glandular tissue, lesser density of parenchymatous cell elements, lesser counts of immunoblasts and small lymphocytes, and larger area of the medulla) in comparison with animals without chemotherapy.
PMID
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Authors

Mayor MeshTerms
Keywords

lymphocytes

mammary tumor

thymus

Journal Title bulletin of experimental biology and medicine
Publication Year Start




PMID- 28243914
OWN - NLM
STAT- MEDLINE
DA  - 20170228
DCOM- 20170315
LR  - 20170315
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 162
IP  - 4
DP  - 2017 Feb
TI  - The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
PG  - 479-482
LID - 10.1007/s10517-017-3644-y [doi]
AB  - Histological study of structural transformations in the thymus of Wistar females 
      in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd
      mamma) and polychemotherapy (6 months after tumor growth initiation;
      cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out. The area of 
      the cortical matter in the thymus decreased 6 months after carcinogenesis
      induction, the percentage of connective tissue elements and glandular tissue and 
      the counts of immunoblasts and cells with pyknotic nuclei increased, this
      indicating the development of accidental involution of the thymus. Animals of the
      experimental tumor+chemotherapy group exhibited morphological signs of lymphocyte
      migration from the thymus and suppressed activities of the lymphoid and
      epithelial components (lesser area of connective tissue elements and glandular
      tissue, lesser density of parenchymatous cell elements, lesser counts of
      immunoblasts and small lymphocytes, and larger area of the medulla) in comparison
      with animals without chemotherapy.
FAU - Kazakov, O V
AU  - Kazakov OV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. 
      [email protected]
FAU - Kabakov, A V
AU  - Kabakov AV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Ishchenko, I Yu
AU  - Ishchenko IY
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Poveshchenko, A F
AU  - Poveshchenko AF
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Raiter, T V
AU  - Raiter TV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Strunkin, D N
AU  - Strunkin DN
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Michurina, S V
AU  - Michurina SV
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
FAU - Konenkov, V I
AU  - Konenkov VI
AD  - Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Carcinogens)
RN  - 684-93-5 (Methylnitrosourea)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - U3P01618RT (Fluorouracil)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Animals
MH  - Antineoplastic Combined Chemotherapy Protocols/*pharmacology
MH  - Carcinogenesis/*drug effects
MH  - Carcinogens/toxicity
MH  - Cell Transformation, Neoplastic/drug effects/pathology
MH  - Cyclophosphamide/administration & dosage
MH  - Epithelial Cells/drug effects/pathology
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Injections, Intraperitoneal
MH  - Lymphocytes/drug effects/pathology
MH  - Macrophages/drug effects/pathology
MH  - Mammary Glands, Animal/drug effects/pathology
MH  - Mammary Neoplasms, Experimental/chemically induced/*drug therapy/pathology
MH  - Methotrexate/administration & dosage
MH  - Methylnitrosourea/toxicity
MH  - Rats, Wistar
MH  - Thymus Gland/*drug effects/pathology
MH  - Thymus Neoplasms/*drug therapy/secondary
OTO - NOTNLM
OT  - lymphocytes
OT  - mammary tumor
OT  - thymus
EDAT- 2017/03/01 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/01 06:00
PHST- 2015/11/23 [received]
AID - 10.1007/s10517-017-3644-y [doi]
AID - 10.1007/s10517-017-3644-y [pii]
PST - ppublish
SO  - Bull Exp Biol Med. 2017 Feb;162(4):479-482. doi: 10.1007/s10517-017-3644-y. Epub 
      2017 Feb 27.

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