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Prevalence of Hepatitis C Virus Infection and Its Risk Factors among Patients Attending Rwanda Military Hospital, Rwanda.

Abstract In Rwanda, the prevalence of viral hepatitis (HCV) is poorly understood. The current study investigated the prevalence and risk factors of HCV infection in Rwanda. A total of 324 patients attending Rwanda Military Hospital were randomly selected and a questionnaire was administered to determine the risk factors. Blood was collected and screened for anti-HCV antibodies and seropositive samples were subjected to polymerase chain reaction method. Hematology abnormalities in the HCV infected patients were also investigated. Anti-HCV antibody and active HCV infection were found in 16.0% and 9.6% of total participants, respectively. Prevalence was highest (28.4%; 19/67) among participants above 55 years and least (2.4%; 3/123) among younger participants (18-35 years). There was a significant (P = 0.031) relationship between place of residence and HCV infection with residents of Southern Province having significantly higher prevalence. The hematological abnormalities observed in the HCV infected patients included leukopenia (48.4%; 15/52), neutropenia (6.5%; 2/52), and thrombocytopenia (25.8%; 8/52). The HCV infection was significantly higher in the older population (>55 years) and exposure to injection from traditional practitioners was identified as a significant (P = 0.036) risk factor of infection. Further studies to determine the factors causing the high prevalence of HCV in Rwanda are recommended.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28246598
OWN - NLM
STAT- MEDLINE
DA  - 20170301
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Prevalence of Hepatitis C Virus Infection and Its Risk Factors among Patients
      Attending Rwanda Military Hospital, Rwanda.
PG  - 5841272
LID - 10.1155/2017/5841272 [doi]
AB  - In Rwanda, the prevalence of viral hepatitis (HCV) is poorly understood. The
      current study investigated the prevalence and risk factors of HCV infection in
      Rwanda. A total of 324 patients attending Rwanda Military Hospital were randomly 
      selected and a questionnaire was administered to determine the risk factors.
      Blood was collected and screened for anti-HCV antibodies and seropositive samples
      were subjected to polymerase chain reaction method. Hematology abnormalities in
      the HCV infected patients were also investigated. Anti-HCV antibody and active
      HCV infection were found in 16.0% and 9.6% of total participants, respectively.
      Prevalence was highest (28.4%; 19/67) among participants above 55 years and least
      (2.4%; 3/123) among younger participants (18-35 years). There was a significant
      (P = 0.031) relationship between place of residence and HCV infection with
      residents of Southern Province having significantly higher prevalence. The
      hematological abnormalities observed in the HCV infected patients included
      leukopenia (48.4%; 15/52), neutropenia (6.5%; 2/52), and thrombocytopenia (25.8%;
      8/52). The HCV infection was significantly higher in the older population (>55
      years) and exposure to injection from traditional practitioners was identified as
      a significant (P = 0.036) risk factor of infection. Further studies to determine 
      the factors causing the high prevalence of HCV in Rwanda are recommended.
FAU - Umumararungu, Esperance
AU  - Umumararungu E
AD  - Department of Molecular Biology and Biotechnology, Institute of Basic Sciences,
      Technology and Innovation (PAUISTI), Pan African University, P.O. Box 6200-00200,
      Nairobi, Kenya; Rwanda Military Hospital, P.O. Box 3377, Kanombe, Kigali, Rwanda.
FAU - Ntaganda, Fabien
AU  - Ntaganda F
AD  - Rwanda Military Hospital, P.O. Box 3377, Kanombe, Kigali, Rwanda.
FAU - Kagira, John
AU  - Kagira J
AUID- ORCID: 0000-0001-5513-2113
AD  - Department of Molecular Biology and Biotechnology, Institute of Basic Sciences,
      Technology and Innovation (PAUISTI), Pan African University, P.O. Box 6200-00200,
      Nairobi, Kenya; Department of Animal Sciences, Faculty of Agriculture, Jomo
      Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya.
FAU - Maina, Naomi
AU  - Maina N
AUID- ORCID: 0000-0001-7577-5140
AD  - Department of Molecular Biology and Biotechnology, Institute of Basic Sciences,
      Technology and Innovation (PAUISTI), Pan African University, P.O. Box 6200-00200,
      Nairobi, Kenya; Department of Biochemistry, School of Biomedical Sciences, Jomo
      Kenyatta University of Agriculture and Technology (JKUAT), P.O. Box 62000-00200, 
      Nairobi, Kenya.
LA  - eng
PT  - Journal Article
DEP - 20170126
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Hepatitis C Antibodies)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Demography
MH  - Female
MH  - Hepacivirus/*physiology
MH  - Hepatitis C/blood/*epidemiology/*virology
MH  - Hepatitis C Antibodies/blood
MH  - Hospitals, Military/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Marital Status
MH  - Middle Aged
MH  - Prevalence
MH  - RNA, Viral/blood/genetics
MH  - Residence Characteristics
MH  - Risk Factors
MH  - Rwanda/epidemiology
MH  - Young Adult
PMC - PMC5299157
COI - The authors declare that they have no competing interests.
EDAT- 2017/03/02 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/02 06:00
PHST- 2016/10/24 [received]
PHST- 2016/12/07 [revised]
PHST- 2016/12/18 [accepted]
AID - 10.1155/2017/5841272 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:5841272. doi: 10.1155/2017/5841272. Epub 2017 Jan 26.

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