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Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.

Abstract Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited.
PMID
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Authors

Mayor MeshTerms

Hippophae

Keywords

Obese mice

PPARα

PPARγ

inflammation

Journal Title pharmaceutical biology
Publication Year Start




PMID- 28248545
OWN - NLM
STAT- MEDLINE
DA  - 20170301
DCOM- 20170313
LR  - 20170313
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet
      induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in
      C57BL/6 mice.
PG  - 1207-1214
LID - 10.1080/13880209.2016.1278454 [doi]
AB  - CONTEXT: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae)
      seed (FSH) has shown beneficial effects in anti-hypertension and lowering
      cholesterol level. However, evidence for its efficacy in treating obesity is
      limited. OBJECTIVE: We sought to determine if FSH can reduce body weight and
      regulate lipid metabolism disorder in high fat diet (HFD)-induced obese mouse
      model, and to investigate potential molecular targets involved. MATERIALS AND
      METHODS: C57BL/6 mice were fed with HFD for 8 weeks to induce obesity. The
      modeled mice were divided into four groups and treated with vehicle,
      rosiglitazone (2 mg/kg), low (100 mg/kg) and high (300 mg/kg) dose of FSH,
      respectively. Normal control was also used. The treatments were administered
      orally for 9 weeks. We measured the effect of FSH on regulating body weight,
      various liver and serum parameters, and molecular targets that are key to lipid
      metabolism. RESULTS: FSH administration at 100 and 300 mg/kg significantly
      reduced body weight gain by 33.06 and 43.51%, respectively. Additionally,
      triglyceride concentration in serum and liver were decreased by 15.67 and 49.56%,
      individually, after FSH (300 mg/kg) treatment. Upon FSH (100 and 300 mg/kg)
      treatment, PPARalpha mRNA expression was upregulated in liver (1.24- and
      1.42-fold) and in adipose tissue (1.66- and 1.72-fold). Furthermore, FSH
      downregulated PPARgamma protein level both in liver and adipose tissue. Moreover,
      FSH inhibited macrophage infiltration into adipose tissues, and downregulated
      TNFalpha mRNA expression in adipose tissue (38.01-47.70%). CONCLUSION: This
      effect was mediated via regulation of PPARgamma and PPARalpha gene expression,
      and suppression of adipose tissue inflammation.
FAU - Yang, Xin
AU  - Yang X
AD  - a School of Life Sciences , East China Normal University , Shanghai , P.R. China.
FAU - Wang, Qian
AU  - Wang Q
AD  - b Institute of Oncology , Shanghai 9th People's Hospital, Shanghai Jiao Tong
      University School of Medicine , Shanghai , P.R. China.
FAU - Pang, Zeng-Run
AU  - Pang ZR
AD  - a School of Life Sciences , East China Normal University , Shanghai , P.R. China.
FAU - Pan, Meng-Ran
AU  - Pan MR
AD  - a School of Life Sciences , East China Normal University , Shanghai , P.R. China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - a School of Life Sciences , East China Normal University , Shanghai , P.R. China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Flavonoids)
RN  - 0 (Plant Extracts)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects/physiology
MH  - Diet, High-Fat/*adverse effects
MH  - Flavonoids/isolation & purification/pharmacology/*therapeutic use
MH  - *Hippophae
MH  - Hypertriglyceridemia/*drug therapy/metabolism
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*drug therapy/metabolism
MH  - Plant Extracts/isolation & purification/pharmacology/*therapeutic use
MH  - Seeds
MH  - Triglycerides/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - Obese mice
OT  - PPARalpha
OT  - PPARgamma
OT  - inflammation
EDAT- 2017/03/02 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/02 06:00
AID - 10.1080/13880209.2016.1278454 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1207-1214. doi: 10.1080/13880209.2016.1278454.

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