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Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia.

Abstract Background Blinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B-cell precursor ALL on the basis of single-group trials that showed efficacy and manageable toxic effects. Methods In this multi-institutional phase 3 trial, we randomly assigned adults with heavily pretreated B-cell precursor ALL, in a 2:1 ratio, to receive either blinatumomab or standard-of-care chemotherapy. The primary end point was overall survival. Results Of the 405 patients who were randomly assigned to receive blinatumomab (271 patients) or chemotherapy (134 patients), 376 patients received at least one dose. Overall survival was significantly longer in the blinatumomab group than in the chemotherapy group. The median overall survival was 7.7 months in the blinatumomab group and 4.0 months in the chemotherapy group (hazard ratio for death with blinatumomab vs. chemotherapy, 0.71; 95% confidence interval [CI], 0.55 to 0.93; P=0.01). Remission rates within 12 weeks after treatment initiation were significantly higher in the blinatumomab group than in the chemotherapy group, both with respect to complete remission with full hematologic recovery (34% vs. 16%, P<0.001) and with respect to complete remission with full, partial, or incomplete hematologic recovery (44% vs. 25%, P<0.001). Treatment with blinatumomab resulted in a higher rate of event-free survival than that with chemotherapy (6-month estimates, 31% vs. 12%; hazard ratio for an event of relapse after achieving a complete remission with full, partial, or incomplete hematologic recovery, or death, 0.55; 95% CI, 0.43 to 0.71; P<0.001), as well as a longer median duration of remission (7.3 vs. 4.6 months). A total of 24% of the patients in each treatment group underwent allogeneic stem-cell transplantation. Adverse events of grade 3 or higher were reported in 87% of the patients in the blinatumomab group and in 92% of the patients in the chemotherapy group. Conclusions Treatment with blinatumomab resulted in significantly longer overall survival than chemotherapy among adult patients with relapsed or refractory B-cell precursor ALL. (Funded by Amgen; TOWER ClinicalTrials.gov number, NCT02013167 .).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the new england journal of medicine
Publication Year Start




PMID- 28249141
OWN - NLM
STAT- MEDLINE
DA  - 20170301
DCOM- 20170310
LR  - 20170310
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 376
IP  - 9
DP  - 2017 Mar 02
TI  - Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia.
PG  - 836-847
LID - 10.1056/NEJMoa1609783 [doi]
AB  - Background Blinatumomab, a bispecific monoclonal antibody construct that enables 
      CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic
      leukemia (ALL) blasts, was approved for use in patients with relapsed or
      refractory B-cell precursor ALL on the basis of single-group trials that showed
      efficacy and manageable toxic effects. Methods In this multi-institutional phase 
      3 trial, we randomly assigned adults with heavily pretreated B-cell precursor
      ALL, in a 2:1 ratio, to receive either blinatumomab or standard-of-care
      chemotherapy. The primary end point was overall survival. Results Of the 405
      patients who were randomly assigned to receive blinatumomab (271 patients) or
      chemotherapy (134 patients), 376 patients received at least one dose. Overall
      survival was significantly longer in the blinatumomab group than in the
      chemotherapy group. The median overall survival was 7.7 months in the
      blinatumomab group and 4.0 months in the chemotherapy group (hazard ratio for
      death with blinatumomab vs. chemotherapy, 0.71; 95% confidence interval [CI],
      0.55 to 0.93; P=0.01). Remission rates within 12 weeks after treatment initiation
      were significantly higher in the blinatumomab group than in the chemotherapy
      group, both with respect to complete remission with full hematologic recovery
      (34% vs. 16%, P&lt;0.001) and with respect to complete remission with full, partial,
      or incomplete hematologic recovery (44% vs. 25%, P&lt;0.001). Treatment with
      blinatumomab resulted in a higher rate of event-free survival than that with
      chemotherapy (6-month estimates, 31% vs. 12%; hazard ratio for an event of
      relapse after achieving a complete remission with full, partial, or incomplete
      hematologic recovery, or death, 0.55; 95% CI, 0.43 to 0.71; P&lt;0.001), as well as 
      a longer median duration of remission (7.3 vs. 4.6 months). A total of 24% of the
      patients in each treatment group underwent allogeneic stem-cell transplantation. 
      Adverse events of grade 3 or higher were reported in 87% of the patients in the
      blinatumomab group and in 92% of the patients in the chemotherapy group.
      Conclusions Treatment with blinatumomab resulted in significantly longer overall 
      survival than chemotherapy among adult patients with relapsed or refractory
      B-cell precursor ALL. (Funded by Amgen; TOWER ClinicalTrials.gov number,
      NCT02013167 .).
FAU - Kantarjian, Hagop
AU  - Kantarjian H
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Stein, Anthony
AU  - Stein A
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Gokbuget, Nicola
AU  - Gokbuget N
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Fielding, Adele K
AU  - Fielding AK
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Schuh, Andre C
AU  - Schuh AC
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Ribera, Josep-Maria
AU  - Ribera JM
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Wei, Andrew
AU  - Wei A
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Dombret, Herve
AU  - Dombret H
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Foa, Robin
AU  - Foa R
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Bassan, Renato
AU  - Bassan R
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Arslan, Onder
AU  - Arslan O
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Sanz, Miguel A
AU  - Sanz MA
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Bergeron, Julie
AU  - Bergeron J
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Demirkan, Fatih
AU  - Demirkan F
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Lech-Maranda, Ewa
AU  - Lech-Maranda E
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Rambaldi, Alessandro
AU  - Rambaldi A
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Thomas, Xavier
AU  - Thomas X
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Horst, Heinz-August
AU  - Horst HA
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Bruggemann, Monika
AU  - Bruggemann M
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Klapper, Wolfram
AU  - Klapper W
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Wood, Brent L
AU  - Wood BL
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Fleishman, Alex
AU  - Fleishman A
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Nagorsen, Dirk
AU  - Nagorsen D
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Holland, Christopher
AU  - Holland C
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Zimmerman, Zachary
AU  - Zimmerman Z
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
FAU - Topp, Max S
AU  - Topp MS
AD  - From the Department of Leukemia, University of Texas M.D. Anderson Cancer Center,
      Houston (H.K.); City of Hope National Medical Center, Duarte (A.S.), and Amgen,
      Thousand Oaks (A.F., D.N., Z.Z.) - both in California; Goethe University,
      University Hospital, Department of Medicine II, Frankfurt am Main (N.G.), Medical
      Department II (H.-A.H., M.B.) and Hematopathology Section and Lymph Node Registry
      (W.K.), University Hospital Schleswig Holstein, Campus Kiel, Kiel, and
      Medizinische Klinik und Poliklinik II, Universitatsklinikums Wurzburg, Wurzburg
      (M.S.T.) - all in Germany; Royal Free Hospital and University College London
      Cancer Institute, London (A.K.F.); Princess Margaret Cancer Centre, Toronto
      (A.C.S.), and Centre Integre Universitaire de Sante et de Services Sociaux de
      l'est de l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal (J.B.) - all
      in Canada; ICO-Hospital Universitari Germans Trias i Pujol, Jose Carreras
      Research Institute, Universitat Autonoma de Barcelona, Barcelona (J.-M.R.), the
      Department of Medicine, Hospital Universitari i Politecnic La Fe, University of
      Valencia, Valencia, and Centro de Investigacion Biomedica en Red de Cancer,
      Instituto Carlos III, Madrid (M.A.S.) - all in Spain; Alfred Hospital and Monash 
      University, Melbourne, VIC, Australia (A.W.); Institut Universitaire
      d'Hematologie, Hopital Saint-Louis (Assistance Publique - Hopitaux de Paris),
      Paris (H.D.), and Centre Hospitalier Lyon Sud, Pierre-Benite (X.T.) - both in
      France; Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia,
      Azienda Ospedaliera Policlinico Umberto I, Universita Sapienza di Roma, Rome
      (R.F.), Azienda Unita Locale Socio Sanitaria 12 Veneziana Ospedale Dell Angelo,
      Venice (R.B.), and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,
      Bergamo, Universita Statale di Milano, Milan (A.R.) - all in Italy; Ankara
      Universitesi, Tip Fakultesi, Cebeci Arastirma ve Uygulama Hastanesi, Ankara
      (O.A.), and Dokuz Eylul Universitesi Tip Fakultesi, Izmir (F.D.) - both in
      Turkey; Instytut Hematologii i Transfuzjologii and Centrum Medyczne Ksztalcenia
      Podyplomowego, Warsaw, Poland (E.L.-M.); University of Washington Medical Center,
      Seattle (B.L.W.); and Amgen, Washington, DC (C.H.).
LA  - eng
SI  - ClinicalTrials.gov/NCT02013167
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Antibodies, Bispecific)
RN  - 0 (Antineoplastic Agents)
RN  - 4FR53SIF3A (blinatumomab)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Bispecific/adverse effects/*therapeutic use
MH  - Antineoplastic Agents/adverse effects/*therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy/mortality/therapy
MH  - Sepsis/chemically induced
MH  - Stem Cell Transplantation
MH  - Survival Analysis
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2017/03/02 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/03/02 06:00
AID - 10.1056/NEJMoa1609783 [doi]
PST - ppublish
SO  - N Engl J Med. 2017 Mar 2;376(9):836-847. doi: 10.1056/NEJMoa1609783.

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