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Humoral and Cellular Immunity Changed after Traumatic Brain Injury in Human Patients.

Abstract Previous studies have suggested that there is a disproportionally higher risk of infection following traumatic brain injury (TBI). This predisposition to infection may be driven by a poorly understood, brain-specific response in the immune system after TBI. However, there is a lack of studies that have fully characterized TBI patients to understand the relationship between TBI and peripheral immune function. In the present study, markers for humoral immunity and cellular immunity were measured for up to 2 weeks in the peripheral blood of 37 patients with TBI in order to elucidate the time course and the type of the peripheral immune response following TBI. 12 relatively healthy individuals without TBI and other neurological diseases were enrolled into the control group. Our data indicated that TBI could induce significant changes in humoral immunity characterized by a decrease in IgG and IgM levels and an increase in the complements C3 and C4 levels in comparison with the control group. Moreover, compared with the control group, a significant reduction in peripheral blood CD3(+) and CD3(+)CD4(+) lymphocyte counts occurred early (days 1-3) following the onset of trauma. These results provide evidence that TBI is associated with substantial changes in humoral immunity and cellular immunity, which may explain the high incidence of infection encountered in these patients.
PMID
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Authors

Mayor MeshTerms

Immunity, Cellular

Immunity, Humoral

Keywords

Cellular immunity

Human

Humoral immunity

Traumatic brain injury

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249910
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - Humoral and Cellular Immunity Changed after Traumatic Brain Injury in Human
      Patients.
PG  - 10-16
AB  - Previous studies have suggested that there is a disproportionally higher risk of 
      infection following traumatic brain injury (TBI). This predisposition to
      infection may be driven by a poorly understood, brain-specific response in the
      immune system after TBI. However, there is a lack of studies that have fully
      characterized TBI patients to understand the relationship between TBI and
      peripheral immune function. In the present study, markers for humoral immunity
      and cellular immunity were measured for up to 2 weeks in the peripheral blood of 
      37 patients with TBI in order to elucidate the time course and the type of the
      peripheral immune response following TBI. 12 relatively healthy individuals
      without TBI and other neurological diseases were enrolled into the control group.
      Our data indicated that TBI could induce significant changes in humoral immunity 
      characterized by a decrease in IgG and IgM levels and an increase in the
      complements C3 and C4 levels in comparison with the control group. Moreover,
      compared with the control group, a significant reduction in peripheral blood CD3+
      and CD3+CD4+ lymphocyte counts occurred early (days 1-3) following the onset of
      trauma. These results provide evidence that TBI is associated with substantial
      changes in humoral immunity and cellular immunity, which may explain the high
      incidence of infection encountered in these patients.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Wang, Jia-Wei
AU  - Wang JW
AD  - Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical
      University, Beijing, P.R. China.
AD  - Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical
      University, Beijing, P.R. China.
FAU - Li, Jin-Ping
AU  - Li JP
AD  - Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical
      University, Beijing, P.R. China.
FAU - Song, Ying-Lun
AU  - Song YL
AD  - Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical
      University, Beijing, P.R. China.
FAU - Zhao, Qi-Huang
AU  - Zhao QH
AD  - Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical
      University, Beijing, P.R. China [email protected]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Immunoglobulin G)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Brain Injuries, Traumatic/blood/*immunology
MH  - Complement System Proteins/metabolism
MH  - Female
MH  - Humans
MH  - *Immunity, Cellular
MH  - *Immunity, Humoral
MH  - Immunoglobulin G/blood
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Cellular immunity
OT  - Human
OT  - Humoral immunity
OT  - Traumatic brain injury
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/10 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):10-16.

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