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Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid Atherosclerosis in Metabolic Syndrome.

Abstract Semaphorin-3E, provoking inflammation and insulin resistance which leads to metabolic syndrome, exerts obscure effects on carotid atherosclerosis in metabolic syndrome. The Tribbles 3 Q84R polymorphism is involved in insulin resistance. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E and what effect semaphorin 3E exerts on carotid atherosclerosis.
PMID
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Authors

Mayor MeshTerms
Keywords

Semaphorin 3E

Tribbles 3

carotid atherosclerosis

metabolic syndrome

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249916
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid
      Atherosclerosis in Metabolic Syndrome.
PG  - 47-51
AB  - OBJECTIVES: Semaphorin-3E, provoking inflammation and insulin resistance which
      leads to metabolic syndrome, exerts obscure effects on carotid atherosclerosis in
      metabolic syndrome. The Tribbles 3 Q84R polymorphism is involved in insulin
      resistance. This study aims to investigate whether the Tribbles 3 Q84R
      polymorphism has profound effects on serum semaphorin 3E and what effect
      semaphorin 3E exerts on carotid atherosclerosis. METHOD: A total of 518 unrelated
      Chinese subjects consisted of control (n=258) and metabolic syndrome (n=260)
      groups. Clinical and biochemical characteristics were collected. The level of
      serum semaphorin 3E was measured by enzyme-linked immunosorbent assay. Genotyping
      of the functional Tribbles 3 Q84R polymorphism was achieved by RFLP-PCR method.
      All subjects underwent carotid ultrasonography to determine carotid intima-media 
      thickness (considered atherosclerosis if above 0.9 mm). RESULTS: Serum semaphorin
      3E was significantly increased in metabolic syndrome (P=0.012) as compared with
      the control group. Among the metabolic syndrome group, those with RR84 genotype
      had significantly higher levels of serum semaphorin 3E than those with QQ84 or
      QR84 genotypes (P=0.003, P=0.004) with similarity amongst the control group.
      Factorial analyses showed statistically significant interactions between RR84
      genotype and metabolic syndrome (P=0.019 for interaction for semaphorin 3E).
      Semaphorin 3E correlated positively with homeostasis model assessment insulin
      resistance (r=0.263, P=0.009) and carotid intima-media thickness (r=0.215,
      P=0.031). On partial analyses, after controlling for confounding factors,
      semaphorin 3E was positively correlated with carotid intima-media thickness
      (P=0.004). CONCLUSION: Individuals with metabolic syndrome demonstrated further
      increased serum semaphorin 3E, especially those with Tribbles 3 RR84 genotype.
      Increased serum semaphorin 3E may in part exacerbate insulin resistance and
      carotid atherosclerosis.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Qin, Ran-Ran
AU  - Qin RR
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Song, Ming
AU  - Song M
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Li, Yi-Hui
AU  - Li YH
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Wang, Feng
AU  - Wang F
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Zhou, Hui-Min
AU  - Zhou HM
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Liu, Ming-Hao
AU  - Liu MH
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Zhong, Ming
AU  - Zhong M
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Zhang, Yun
AU  - Zhang Y
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China.
FAU - Wang, Zhi-Hao
AU  - Wang ZH
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
      Ministry of Education and Chinese Ministry of Health, The State and Shandong
      Province Joint Key Laboratory of Translational Cardiovascular Medicine,
      Department of Cardiology Qilu Hospital of Shandong University, Ji'nan, China
      wangzhihaosdu@126.com.
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Ji'nan, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SEMA3E protein, human)
RN  - 0 (Semaphorins)
RN  - 0 (TRIB3 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carotid Artery Diseases/*blood/complications/*genetics
MH  - Cell Cycle Proteins/*genetics
MH  - Demography
MH  - Female
MH  - Gene Frequency/genetics
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome X/*blood/complications/*genetics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Protein-Serine-Threonine Kinases/*antagonists & inhibitors/genetics
MH  - Repressor Proteins/*genetics
MH  - Semaphorins/*blood
OTO - NOTNLM
OT  - Semaphorin 3E
OT  - Tribbles 3
OT  - carotid atherosclerosis
OT  - metabolic syndrome
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/47 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):47-51.

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