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HbA1c and Glycated Albumin Levels Are High in Gastrectomized Subjects with Iron-Deficiency Anemia.

Abstract We report that glycated albumin (GA) is higher relative to HbA1c in non-diabetic, gastrectomized subjects without anemia, and thus is a sign of oxyhyperglycemia. It is known that gastrectomized subjects are prone to iron-deficiency anemia (IDA), and that the HbA1c levels of subjects with IDA are falsely high. In the present study, the HbA1c and GA levels of gastrectomized subjects with IDA were compared with gastrectomized subjects without anemia. Seven non-diabetic gastrectomized subjects with IDA were enrolled in the present study. Twenty-eight non-diabetic gastrectomized subjects without anemia matched with the subjects with IDA in terms of age, gender, and body mass index were used as the controls. Although there were no significant differences in fasting plasma glucose and OGTT 2-hour plasma glucose (2-h PG) between the two groups, the HbA1c and GA levels in gastrectomized subjects with IDA were significantly higher than the controls. For all of the gastrectomized subjects (n=35), ferritin exhibited a significant negative correlation with HbA1c and GA, and a significant positive correlation with 2-h PG. In addition, the HbA1c and GA levels exhibited a significant negative correlation with the mean corpuscular hemoglobin and hemoglobin. The HbA1c and GA levels in gastrectomized subjects with IDA were significantly higher than those in controls. The high GA levels are attributed to a tendency in which patients with total gastrectomy, who are prone to IDA, are susceptible to postprandial hyperglycemia and reactive hypoglycemia, which in turn leads to large fluctuations in plasma glucose.
PMID
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Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects.

Authors

Mayor MeshTerms

Gastrectomy

Keywords

Gastrectomy

Glycated albumin

HbA1c

Iron deficiency anemia

Oxyhyperglycemia

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249917
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - HbA1c and Glycated Albumin Levels Are High in Gastrectomized Subjects with
      Iron-Deficiency Anemia.
PG  - 52-57
AB  - We report that glycated albumin (GA) is higher relative to HbA1c in non-diabetic,
      gastrectomized subjects without anemia, and thus is a sign of oxyhyperglycemia.
      It is known that gastrectomized subjects are prone to iron-deficiency anemia
      (IDA), and that the HbA1c levels of subjects with IDA are falsely high. In the
      present study, the HbA1c and GA levels of gastrectomized subjects with IDA were
      compared with gastrectomized subjects without anemia. Seven non-diabetic
      gastrectomized subjects with IDA were enrolled in the present study. Twenty-eight
      non-diabetic gastrectomized subjects without anemia matched with the subjects
      with IDA in terms of age, gender, and body mass index were used as the controls. 
      Although there were no significant differences in fasting plasma glucose and OGTT
      2-hour plasma glucose (2-h PG) between the two groups, the HbA1c and GA levels in
      gastrectomized subjects with IDA were significantly higher than the controls. For
      all of the gastrectomized subjects (n=35), ferritin exhibited a significant
      negative correlation with HbA1c and GA, and a significant positive correlation
      with 2-h PG. In addition, the HbA1c and GA levels exhibited a significant
      negative correlation with the mean corpuscular hemoglobin and hemoglobin. The
      HbA1c and GA levels in gastrectomized subjects with IDA were significantly higher
      than those in controls. The high GA levels are attributed to a tendency in which 
      patients with total gastrectomy, who are prone to IDA, are susceptible to
      postprandial hyperglycemia and reactive hypoglycemia, which in turn leads to
      large fluctuations in plasma glucose.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Inada, Shinya
AU  - Inada S
AD  - Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan.
FAU - Koga, Masafumi
AU  - Koga M
AD  - Department of Internal Medicine, Hakuhokai Central Hospital, Hyogo, Japan
      [email protected]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Blood Glucose)
RN  - 0 (Hemoglobin A, Glycosylated)
RN  - 0 (Serum Albumin)
RN  - 0 (glycosylated serum albumin)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Anemia, Iron-Deficiency/*blood/complications
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/blood/complications
MH  - Fasting/blood
MH  - Female
MH  - Ferritins/metabolism
MH  - *Gastrectomy
MH  - Hemoglobin A, Glycosylated/*metabolism
MH  - Humans
MH  - Hyperglycemia/blood/complications
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin/*metabolism
OTO - NOTNLM
OT  - Gastrectomy
OT  - Glycated albumin
OT  - HbA1c
OT  - Iron deficiency anemia
OT  - Oxyhyperglycemia
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/52 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):52-57.

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