PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Evaluation of Plasma Platelet Microparticles in Thrombotic Thrombocytopenic Purpura.

Abstract Platelet microparticles (PMPs) have a procoagulant activity about 50-100 times greater than active platelets due to high expression of negatively charged phospholipids on their surfaces. In this study, we evaluated microparticle immunophenotyping and also plasma PMPs level in patients with Thrombotic Thrombocytopenic Purpura (TTP) in Southern Iran.
PMID
Related Publications

Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles.

Flow cytometric detection of circulating platelet-derived microparticles in healthy adult horses.

Platelet microparticles in immune thrombocytopenic purpura in pediatrics.

Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease.

Platelet-derived microvesicles in thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.

Authors

Mayor MeshTerms
Keywords

Cell-derived microparticles

Immunophenotyping

Microangiopathic hemolytic anemia

Thrombotic Thrombocytopenic Purpura

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249919
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - Evaluation of Plasma Platelet Microparticles in Thrombotic Thrombocytopenic
      Purpura.
PG  - 62-67
AB  - BACKGROUND: Platelet microparticles (PMPs) have a procoagulant activity about
      50-100 times greater than active platelets due to high expression of negatively
      charged phospholipids on their surfaces. In this study, we evaluated
      microparticle immunophenotyping and also plasma PMPs level in patients with
      Thrombotic Thrombocytopenic Purpura (TTP) in Southern Iran. METHOD: We had two
      study groups: 15 TTP patients and 15 healthy control group and PMPs from platelet
      concentrate (PC) at the 5th day of storage. Microparticles were prepared in two
      steps, by low and high centrifugation followed by size confirmation via 'Dynamic 
      Light Scattering (DLS)' Zetasizer. Immunophenotyping of PMPs was done via flow
      cytometry, using a FACS Calibur flow cytometer (BD, USA). PMPs counts were
      obtained using Partec-cyflow and Polysciences Microbeads (1 micron in diameter). 
      Results were analyzed using FlowJo 7.6 (Treestar, USA) and Partec FlowMax
      software. RESULTS: Our results showed that the majority of microparticles in TTP 
      patients and normal individuals were PMPs and also demonstrated that the plasma
      PMPs level in TTP patients was higher than the normal control group
      (P-value<0.001). CONCLUSION: It seems that elevated PMPs level in TTP patients
      could be related to thrombotic events. Nevertheless, more studies are needed to
      confirm these results.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Tahmasbi, Leila
AU  - Tahmasbi L
AD  - Blood Transfusion Research Center, High Institute for Research and Education in
      Transfusion Medicine, Tehran, Iran.
FAU - Karimi, Mehran
AU  - Karimi M
AD  - Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Kafiabadi, Sedigheh Amini
AU  - Kafiabadi SA
AD  - Blood Transfusion Research Center, High Institute for Research and Education in
      Transfusion Medicine, Tehran, Iran [email protected]
FAU - Nikougoftar, Mahin
AU  - Nikougoftar M
AD  - Blood Transfusion Research Center, High Institute for Research and Education in
      Transfusion Medicine, Tehran, Iran.
FAU - Haghpanah, Sezaneh
AU  - Haghpanah S
AD  - Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Ranjbaran, Reza
AU  - Ranjbaran R
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of
      Paramedical Sciences, Shiraz University of Medical sciences, Shiraz, Iran.
FAU - Moghadam, Mohamad
AU  - Moghadam M
AD  - Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
SB  - IM
MH  - Adult
MH  - Blood Platelets/*metabolism
MH  - Cell-Derived Microparticles/*metabolism
MH  - Dynamic Light Scattering
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunophenotyping
MH  - Male
MH  - Particle Size
MH  - Platelet Count
MH  - Purpura, Thrombotic Thrombocytopenic/*blood
OTO - NOTNLM
OT  - Cell-derived microparticles
OT  - Immunophenotyping
OT  - Microangiopathic hemolytic anemia
OT  - Thrombotic Thrombocytopenic Purpura
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/62 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):62-67.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>