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Hemoglobin Wayne Trait with Incidental Polycythemia.

Abstract Hemoglobinopathies, caused by mutations in the globin genes, are one of the most common inherited disorders. Many of the hemoglobin variants can be identified by hemoglobin analysis using conventional electrophoresis and high performance liquid chromatography; however hemoglobin DNA analysis may be necessary in other cases for confirmation. Here, we report a case of a rare alpha chain hemoglobin variant, hemoglobin Wayne, in a 47-year-old man who presented with secondary polycythemia. Capillary zone electrophoresis and high performance liquid chromatography revealed a significant amount of a hemoglobin variant, which was further confirmed by hemoglobin DNA sequencing as hemoglobin Wayne. Since the patient was not homozygous for hemoglobin Wayne, which is associated with secondary polycythemia, the laboratory diagnosis in this case was critical in ruling out hemoglobinopathy as the etiology of his polycythemia.
PMID
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Authors

Mayor MeshTerms
Keywords

Hemoglobinopathies

alpha globin chain variant

hemoglobin Wayne

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249925
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - Hemoglobin Wayne Trait with Incidental Polycythemia.
PG  - 96-98
AB  - Hemoglobinopathies, caused by mutations in the globin genes, are one of the most 
      common inherited disorders. Many of the hemoglobin variants can be identified by 
      hemoglobin analysis using conventional electrophoresis and high performance
      liquid chromatography; however hemoglobin DNA analysis may be necessary in other 
      cases for confirmation. Here, we report a case of a rare alpha chain hemoglobin
      variant, hemoglobin Wayne, in a 47-year-old man who presented with secondary
      polycythemia. Capillary zone electrophoresis and high performance liquid
      chromatography revealed a significant amount of a hemoglobin variant, which was
      further confirmed by hemoglobin DNA sequencing as hemoglobin Wayne. Since the
      patient was not homozygous for hemoglobin Wayne, which is associated with
      secondary polycythemia, the laboratory diagnosis in this case was critical in
      ruling out hemoglobinopathy as the etiology of his polycythemia.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Ambelil, Manju
AU  - Ambelil M
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health
      Science Center-McGovern Medical School, Houston, TX, USA.
FAU - Nguyen, Nghia
AU  - Nguyen N
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health
      Science Center-McGovern Medical School, Houston, TX, USA.
FAU - Dasgupta, Amitava
AU  - Dasgupta A
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health
      Science Center-McGovern Medical School, Houston, TX, USA.
FAU - Risin, Semyon
AU  - Risin S
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health
      Science Center-McGovern Medical School, Houston, TX, USA.
FAU - Wahed, Amer
AU  - Wahed A
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health
      Science Center-McGovern Medical School, Houston, TX, USA [email protected]
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Hemoglobins, Abnormal)
RN  - 0 (hemoglobin Wayne)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Electrophoresis, Capillary
MH  - Hemoglobins, Abnormal/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polycythemia/*blood
OTO - NOTNLM
OT  - *Hemoglobinopathies
OT  - *alpha globin chain variant
OT  - *hemoglobin Wayne
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/96 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):96-98.

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