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Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature Review.

Abstract Sclerosing pneumocytoma (SP) is a rare entity. Diagnosis of SP can be problematic especially on biopsy specimens, in particular, when the sample is obtained from the papillary component.
PMID
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Pitfalls and Key Features of a Case of Sclerosing Pneumocytoma: A Cytological Challenge?

Authors

Mayor MeshTerms
Keywords

Napsin A

Sclerosing pneumocytoma

TTF-1

sclerosing hemangioma

Journal Title annals of clinical and laboratory science
Publication Year Start




PMID- 28249927
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 1
DP  - 2017 Jan
TI  - Sclerosing Pneumocytoma: a Carcinoma Mimicker. A Case Report and Literature
      Review.
PG  - 103-105
AB  - OBJECTIVES: Sclerosing pneumocytoma (SP) is a rare entity. Diagnosis of SP can be
      problematic especially on biopsy specimens, in particular, when the sample is
      obtained from the papillary component. METHODS: An asymptomatic 33 year-old
      female with no smoking history was incidentally found to have a lung mass. She
      was diagnosed to have well-differentiated adenocarcinoma with papillary features 
      on biopsy. A lobectomy was performed. RESULTS: The circumscribed mass was
      composed predominately of papillary structures, with the "surface cuboidal cells"
      located on the surface of the papillae and "round cells" in the stalks of the
      papillae. Immunohistochemical staining demonstrated nuclear reactivity for TTF-1 
      in both cell types and Napsin A positivity only in "surface" cells. CONCLUSIONS: 
      In evaluation of a lung biopsy from a mass with a predominantly papillary
      pattern, sclerosing pneumocytoma (sclerosing hemangioma in previous
      classifications) should always be in the differential diagnoses.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Zhou, Jain
AU  - Zhou J
AD  - Department of Pathology and Laboratory Medicine, the UT Health-McGovern Medical
      School, Houston, TX, USA.
FAU - Covinsky, Michael H
AU  - Covinsky MH
AD  - Department of Pathology and Laboratory Medicine, the UT Health-McGovern Medical
      School, Houston, TX, USA [email protected]
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Lung/*pathology/surgery
MH  - Lung Neoplasms/diagnostic imaging/*pathology/surgery
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - *Napsin A
OT  - *Sclerosing pneumocytoma
OT  - *TTF-1
OT  - *sclerosing hemangioma
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
AID - 47/1/103 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Jan;47(1):103-105.

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