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Electrospun Nanofibers Loaded with Quercetin Promote the Recovery of Focal Entrapment Neuropathy in a Rat Model of Streptozotocin-Induced Diabetes.

Abstract In this study, quercetin-loaded zein-based nanofibers were developed using electrospinning technique. The therapeutic effect of these quercetin-loaded nanofibers on neuropathy in streptozotocin- (STZ-) induced diabetes in rats was assessed. Diabetic condition was induced in male Wistar rats by STZ, after which a crush injury of the right sciatic nerve was performed to induce mononeuropathy. Functional recovery was assessed using walking track analysis, measurements of foot withdrawal reflex, nerve conduction velocity, and morphological analysis. The oxidative stress status and the ratio of phosphorylated extracellular recognition kinase (pERK)/extracellular recognition kinase (ERK) expression in the nerve lesion were also assessed in order to elucidate the potential mechanisms involved. Results showed that quercetin-loaded zein-based nanofibers slightly enhanced functional recovery from neuropathy in STZ-diabetic rats. The potential mechanism might partially involve improvements in oxidative stress status and the ratio of pERK/ERK expression in the nerve lesion.
PMID
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Authors

Mayor MeshTerms

Recovery of Function

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28251151
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Electrospun Nanofibers Loaded with Quercetin Promote the Recovery of Focal
      Entrapment Neuropathy in a Rat Model of Streptozotocin-Induced Diabetes.
PG  - 2017493
LID - 10.1155/2017/2017493 [doi]
AB  - In this study, quercetin-loaded zein-based nanofibers were developed using
      electrospinning technique. The therapeutic effect of these quercetin-loaded
      nanofibers on neuropathy in streptozotocin- (STZ-) induced diabetes in rats was
      assessed. Diabetic condition was induced in male Wistar rats by STZ, after which 
      a crush injury of the right sciatic nerve was performed to induce mononeuropathy.
      Functional recovery was assessed using walking track analysis, measurements of
      foot withdrawal reflex, nerve conduction velocity, and morphological analysis.
      The oxidative stress status and the ratio of phosphorylated extracellular
      recognition kinase (pERK)/extracellular recognition kinase (ERK) expression in
      the nerve lesion were also assessed in order to elucidate the potential
      mechanisms involved. Results showed that quercetin-loaded zein-based nanofibers
      slightly enhanced functional recovery from neuropathy in STZ-diabetic rats. The
      potential mechanism might partially involve improvements in oxidative stress
      status and the ratio of pERK/ERK expression in the nerve lesion.
FAU - Thipkaew, Chonlathip
AU  - Thipkaew C
AD  - Department of Physiology and Graduate School (Neuroscience Program), Faculty of
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Integrative
      Complementary and Alternative Medicine Research and Development Center, Khon Kaen
      University, Khon Kaen 40002, Thailand.
FAU - Wattanathorn, Jintanaporn
AU  - Wattanathorn J
AUID- ORCID: 0000-0002-7383-2348
AD  - Integrative Complementary and Alternative Medicine Research and Development
      Center, Khon Kaen University, Khon Kaen 40002, Thailand; Department of
      Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Muchimapura, Supaporn
AU  - Muchimapura S
AUID- ORCID: 0000-0001-7756-1955
AD  - Integrative Complementary and Alternative Medicine Research and Development
      Center, Khon Kaen University, Khon Kaen 40002, Thailand; Department of
      Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170130
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Polymers)
RN  - 9010-66-6 (Zein)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Animals
MH  - Axons/drug effects/pathology
MH  - Diabetes Mellitus, Experimental/*drug
      therapy/enzymology/pathology/physiopathology
MH  - Diabetic Neuropathies/*drug therapy/enzymology/pathology/*physiopathology
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Male
MH  - Nanofibers/*chemistry/ultrastructure
MH  - Nanotechnology/*methods
MH  - Oxidative Stress/drug effects
MH  - Phosphorylation/drug effects
MH  - Polymers/chemistry
MH  - Quercetin/pharmacology/*therapeutic use
MH  - Rats, Wistar
MH  - *Recovery of Function/drug effects
MH  - Sciatic Nerve/drug effects/enzymology/pathology/physiopathology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - X-Ray Diffraction
MH  - Zein/chemistry
PMC - PMC5304310
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
PHST- 2016/10/17 [received]
PHST- 2016/12/29 [accepted]
AID - 10.1155/2017/2017493 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:2017493. doi: 10.1155/2017/2017493. Epub 2017 Jan 30.

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