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Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients.

Abstract Background. To investigate the relationships among blood glucose, mixed saliva glucose, and parotid glucose in type 2 diabetes patients and to evaluate the diagnostic and monitoring value of salivary gland glucose in patients with type 2 diabetes (type 2DM). Material and Methods. Thirty patients with type 2DM and 30 healthy age- and sex-matched individuals were included in this study. Glucose levels in unstimulated mixed saliva and in unstimulated parotid saliva were measured by the glucose oxidase peroxidase method. Results. The blood glucose and parotid salivary glucose levels in type 2DM patients were significantly higher than those in the controls (P < 0.05). The blood glucose, parotid salivary glucose, and mixed salivary glucose were 7.46 ± 1.44 mmol/L, 0.18 ± 0.19 mmol/L, and 3.17 × 10(-2) ± 2.84 × 10(-2) mmol/L, respectively, in the type 2DM group; the corresponding glucose levels in the control group were 5.56 ± 0.71 mmol/L, 7.70 × 10(-2) ± 6.02 × 10(-2) mmol/L, and 3.47 × 10(-2) ± 2.79 × 10(-2) mmol/L. The parotid salivary and blood glucose levels in type 2DM patients were strongly correlated; the linear regression equation for blood glucose and parotid salivary glucose was Y = 6.267X + 6.360, with r = 0.810. However, mixed salivary glucose levels were not significantly different in the type 2 diabetes group compared with the control group. Conclusion. Our results suggest that parotid salivary glucose has potential as a biomarker to monitor type 2DM and as a painless, noninvasive method for the management of type 2DM.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28251153
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and
      Monitoring Type 2 Diabetes Mellitus Patients.
PG  - 2569707
LID - 10.1155/2017/2569707 [doi]
AB  - Background. To investigate the relationships among blood glucose, mixed saliva
      glucose, and parotid glucose in type 2 diabetes patients and to evaluate the
      diagnostic and monitoring value of salivary gland glucose in patients with type 2
      diabetes (type 2DM). Material and Methods. Thirty patients with type 2DM and 30
      healthy age- and sex-matched individuals were included in this study. Glucose
      levels in unstimulated mixed saliva and in unstimulated parotid saliva were
      measured by the glucose oxidase peroxidase method. Results. The blood glucose and
      parotid salivary glucose levels in type 2DM patients were significantly higher
      than those in the controls (P &lt; 0.05). The blood glucose, parotid salivary
      glucose, and mixed salivary glucose were 7.46 +/- 1.44 mmol/L, 0.18 +/- 0.19
      mmol/L, and 3.17 x 10-2 +/- 2.84 x 10-2 mmol/L, respectively, in the type 2DM
      group; the corresponding glucose levels in the control group were 5.56 +/- 0.71
      mmol/L, 7.70 x 10-2 +/- 6.02 x 10-2 mmol/L, and 3.47 x 10-2 +/- 2.79 x 10-2
      mmol/L. The parotid salivary and blood glucose levels in type 2DM patients were
      strongly correlated; the linear regression equation for blood glucose and parotid
      salivary glucose was Y = 6.267X + 6.360, with r = 0.810. However, mixed salivary 
      glucose levels were not significantly different in the type 2 diabetes group
      compared with the control group. Conclusion. Our results suggest that parotid
      salivary glucose has potential as a biomarker to monitor type 2DM and as a
      painless, noninvasive method for the management of type 2DM.
FAU - Wang, Beibei
AU  - Wang B
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China; Beijing Coloproctological Hospital (Beijing Erlonglu 
      Hospital), Beijing, China.
FAU - Du, Juan
AU  - Du J
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China.
FAU - Zhu, Zhao
AU  - Zhu Z
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China.
FAU - Ma, Zhihong
AU  - Ma Z
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China.
FAU - Wang, Songlin
AU  - Wang S
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China.
FAU - Shan, Zhaochen
AU  - Shan Z
AUID- ORCID: 0000-0003-3990-9011
AD  - Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical
      University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/*metabolism
MH  - Female
MH  - Glucose/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parotid Gland/*metabolism
MH  - Saliva/*chemistry
MH  - Salivation
PMC - PMC5306981
COI - The authors declare that they have no competing interests.
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
PHST- 2016/08/27 [received]
PHST- 2017/01/16 [accepted]
AID - 10.1155/2017/2569707 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:2569707. doi: 10.1155/2017/2569707. Epub 2017 Jan 31.

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