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Molecular and Histopathological Changes Associated with Keratoconus.

Abstract Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal transplantation in the Western countries. KC usually starts at puberty and progresses until the third or fourth decade; however its progression differs among patients. In the keratoconic cornea, all layers except the endothelium have been shown to have histopathological structural changes. Despite numerous studies in the last several decades, the mechanisms of KC development and progression remain unclear. Both genetic and environmental factors may contribute to the pathogenesis of KC. Many previous articles have reviewed the genetic aspects of KC, but in this review we summarize the histopathological features of different layers of cornea and discuss the differentially expressed proteins in the KC-affected cornea. This summary will help emphasize the major molecular defects in KC and identify additional research areas related to KC, potentially opening up possibilities for novel methods of KC prevention and therapeutic intervention.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28251158
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Molecular and Histopathological Changes Associated with Keratoconus.
PG  - 7803029
LID - 10.1155/2017/7803029 [doi]
AB  - Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual
      acuity through ectasia, opacity, and irregular astigmatism. It is one of the
      leading indicators for corneal transplantation in the Western countries. KC
      usually starts at puberty and progresses until the third or fourth decade;
      however its progression differs among patients. In the keratoconic cornea, all
      layers except the endothelium have been shown to have histopathological
      structural changes. Despite numerous studies in the last several decades, the
      mechanisms of KC development and progression remain unclear. Both genetic and
      environmental factors may contribute to the pathogenesis of KC. Many previous
      articles have reviewed the genetic aspects of KC, but in this review we summarize
      the histopathological features of different layers of cornea and discuss the
      differentially expressed proteins in the KC-affected cornea. This summary will
      help emphasize the major molecular defects in KC and identify additional research
      areas related to KC, potentially opening up possibilities for novel methods of KC
      prevention and therapeutic intervention.
FAU - Khaled, Mariam Lotfy
AU  - Khaled ML
AD  - Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
FAU - Helwa, Inas
AU  - Helwa I
AD  - Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
FAU - Drewry, Michelle
AU  - Drewry M
AD  - Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
FAU - Seremwe, Mutsa
AU  - Seremwe M
AD  - Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
FAU - Estes, Amy
AU  - Estes A
AD  - Department of Ophthalmology, Augusta University, Augusta, GA, USA; James & Jean
      Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
FAU - Liu, Yutao
AU  - Liu Y
AUID- ORCID: 0000-0003-2870-4504
AD  - Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA;
      James & Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, 
      USA; Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, 
      GA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170130
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Hormones)
SB  - IM
MH  - Cornea/pathology
MH  - Homeostasis
MH  - Hormones/metabolism
MH  - Humans
MH  - Keratoconus/*genetics/*pathology
MH  - Models, Biological
PMC - PMC5303843
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
PHST- 2016/09/28 [received]
PHST- 2016/12/16 [revised]
PHST- 2017/01/04 [accepted]
AID - 10.1155/2017/7803029 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:7803029. doi: 10.1155/2017/7803029. Epub 2017 Jan 30.

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