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Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study.

Abstract This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group. Results showed that, after therapy, the increase in endometrial thickness of aspirin groups was superior to control group (P < 0.05). The scores of intrauterine adhesion and menstruation were significantly improved in balloon group as compared to nonballoon group and control group, and significant differences were also observed between nonballoon group and control group (P < 0.05). Of 97 patients, 44.3% became pregnant after surgery, the live birth rate was 27.8%, and the miscarriage rate was 37.2%, but there were no significant differences among three groups (P > 0.05). Thus, aspirin may promote the uterine endometrial growth and repair after surgery for sIUA, and IUD in combination with intrauterine balloon may reduce the recurrence of intrauterine adhesion, but their effect on the reproductive prognosis is required to be further studied.
PMID
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Authors

Mayor MeshTerms

Uterine Balloon Tamponade

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28251159
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and
      Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A
      Prospective Cohort Study.
PG  - 8526104
LID - 10.1155/2017/8526104 [doi]
AB  - This study aimed to investigate the effects of estrogen in combination with
      aspirin and intrauterine balloon on the uterine endometrial repair and
      reproductive prognosis in patients after surgery for severe intrauterine adhesion
      (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device
      (IUD) was placed and oral estrogen was administered after surgery. Patients were 
      divided into control group and aspirin group. In addition, patients in aspirin
      group were subdivided into nonballoon group and balloon group. Results showed
      that, after therapy, the increase in endometrial thickness of aspirin groups was 
      superior to control group (P &lt; 0.05). The scores of intrauterine adhesion and
      menstruation were significantly improved in balloon group as compared to
      nonballoon group and control group, and significant differences were also
      observed between nonballoon group and control group (P &lt; 0.05). Of 97 patients,
      44.3% became pregnant after surgery, the live birth rate was 27.8%, and the
      miscarriage rate was 37.2%, but there were no significant differences among three
      groups (P &gt; 0.05). Thus, aspirin may promote the uterine endometrial growth and
      repair after surgery for sIUA, and IUD in combination with intrauterine balloon
      may reduce the recurrence of intrauterine adhesion, but their effect on the
      reproductive prognosis is required to be further studied.
FAU - Chen, Yuqing
AU  - Chen Y
AUID- ORCID: 0000-0002-1824-9168
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun
      Yat-sen University, Guangzhou, China.
FAU - Liu, Lixiang
AU  - Liu L
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun
      Yat-sen University, Guangzhou, China.
FAU - Luo, Yuanna
AU  - Luo Y
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun
      Yat-sen University, Guangzhou, China.
FAU - Chen, Minghui
AU  - Chen M
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun
      Yat-sen University, Guangzhou, China.
FAU - Huan, Yang
AU  - Huan Y
AUID- ORCID: 0000-0001-8511-2172
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun
      Yat-sen University, Guangzhou, China.
FAU - Fang, Ruili
AU  - Fang R
AD  - Department of Gynecology Ward II, Shenzhen Luohu People's Hospital, Shenzhen
      518000, China.
LA  - eng
PT  - Journal Article
DEP - 20170130
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aspirin/pharmacology/*therapeutic use
MH  - Endometrium/diagnostic imaging/*pathology/physiopathology/surgery
MH  - Female
MH  - Humans
MH  - Hysteroscopy
MH  - Menstruation/drug effects
MH  - Postoperative Care
MH  - Pregnancy
MH  - Prognosis
MH  - Prospective Studies
MH  - Reproduction/*drug effects
MH  - Tissue Adhesions/*drug therapy/pathology/physiopathology/surgery
MH  - *Uterine Balloon Tamponade
MH  - Uterine Diseases/*drug therapy/pathology/physiopathology/*surgery
MH  - Wound Healing/*drug effects
PMC - PMC5303840
COI - The authors declare that they have no competing interests.
EDAT- 2017/03/03 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/03 06:00
PHST- 2016/10/21 [received]
PHST- 2017/01/05 [revised]
PHST- 2017/01/10 [accepted]
AID - 10.1155/2017/8526104 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:8526104. doi: 10.1155/2017/8526104. Epub 2017 Jan 30.

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