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Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia.

Abstract Preeclampsia is a common condition unique to pregnant women. Previous studies have suggested that several cytokines may contribute to defective placental invasion and endothelial damage in this condition. We investigated the influence of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C, -597G/A, and -174G/C) and IL-10 (-592A/C) on susceptibility to preeclampsia in a Chinese population. This study included 142 newly diagnosed preeclampsia patients and 260 controls recruited from Qingdao Women and Children's Hospital between January 2013 and May 2015. Genotyping of IL-6 and IL-10 SNPs was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Logistic regression analysis was then performed to determine the association between these variants and preeclampsia risk. Our findings indicated that compared to the AA genotype, the CC and AC+CC genotypes of IL-10 -592A/C correlate with elevated risk of developing preeclampsia, with adjusted odds ratios (and 95% confidence intervals) of 2.45 (1.26-4.72) and 1.71 (1.09-2.68), respectively. However, the IL-6 -572G/C, -597G/A, and -174G/C polymorphisms were not found to play a critical role in susceptibility to this disorder. In conclusion, the IL-10 -592A/C genetic variant was observed to be associated with preeclampsia risk in pregnant women.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title genetics and molecular research : gmr
Publication Year Start




PMID- 28252161
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170317
LR  - 20170317
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Feb 23
TI  - Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of 
      preeclampsia.
LID - 10.4238/gmr16018588 [doi]
AB  - Preeclampsia is a common condition unique to pregnant women. Previous studies
      have suggested that several cytokines may contribute to defective placental
      invasion and endothelial damage in this condition. We investigated the influence 
      of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C,
      -597G/A, and -174G/C) and IL-10 (-592A/C) on susceptibility to preeclampsia in a 
      Chinese population. This study included 142 newly diagnosed preeclampsia patients
      and 260 controls recruited from Qingdao Women and Children's Hospital between
      January 2013 and May 2015. Genotyping of IL-6 and IL-10 SNPs was performed using 
      the polymerase chain reaction-restriction fragment length polymorphism method.
      Logistic regression analysis was then performed to determine the association
      between these variants and preeclampsia risk. Our findings indicated that
      compared to the AA genotype, the CC and AC+CC genotypes of IL-10 -592A/C
      correlate with elevated risk of developing preeclampsia, with adjusted odds
      ratios (and 95% confidence intervals) of 2.45 (1.26-4.72) and 1.71 (1.09-2.68),
      respectively. However, the IL-6 -572G/C, -597G/A, and -174G/C polymorphisms were 
      not found to play a critical role in susceptibility to this disorder. In
      conclusion, the IL-10 -592A/C genetic variant was observed to be associated with 
      preeclampsia risk in pregnant women.
FAU - Fan, D M
AU  - Fan DM
AD  - Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, China.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, China.
FAU - Liu, X L
AU  - Liu XL
AD  - Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, China.
FAU - Zhang, A
AU  - Zhang A
AD  - Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, China.
FAU - Xu, Q
AU  - Xu Q
AD  - Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, China
      xuqianxn@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170223
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Asian Continental Ancestry Group/genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Interleukin-6/*genetics
MH  - Logistic Models
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Pre-Eclampsia/ethnology/*genetics
MH  - Pregnancy
MH  - Promoter Regions, Genetic/genetics
MH  - Risk Factors
MH  - Young Adult
EDAT- 2017/03/03 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/03 06:00
AID - gmr-16-01-gmr.16018588 [pii]
AID - 10.4238/gmr16018588 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Feb 23;16(1). doi: 10.4238/gmr16018588.

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