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A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies.

Abstract Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clinical, and laboratory data from 124,865 patients with chronic CHB infection were analyzed. Viral genotypes were determined by nested polymerase chain reaction. A chemiluminescent assay was applied to measure HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb in sera. Among 124,865 patients with CHB infection, 324 (0.3%) were concurrently positive for HBsAg and anti-HBs, and 206 (0.2%) were concurrently positive for HBeAg and anti-HBe. The HBeAg+/anti-HBe+ group was composed of younger patients (P < 0.05). Subgenotype B2 was prevalent in HBV patients concurrently positive for HBeAg and anti-HBe, while HBV patients positive for both HBsAg and anti-HBs exhibited the C2 subgenotype. Among 530 concurrent patients, 126 (39%) HBsAg+/anti-HBs+ patients were in the low-replication phase, and 62 (19%) were in the reactivation phase; 87 (42%) HBeAg+/anti-HBe+, and 19 (6%) HBsAg+/anti-HBs+ patients were in the immune clearance phase. In this large-scale analysis, the clinical and viral characteristics of HBV infections with concurrent HBs Ag/antibody or HBe Ag/antibody presentations have been examined, and the results may contribute to the diagnosis and treatment of CHB patients.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title genetics and molecular research : gmr
Publication Year Start




PMID- 28252163
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170317
LR  - 20170317
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Feb 23
TI  - A large-scale analysis study on the clinical and viral characteristics of
      hepatitis B infection with concurrence of hepatitis B surface or E antigens and
      their corresponding antibodies.
LID - 10.4238/gmr16019102 [doi]
AB  - Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody
      or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with
      chronic hepatitis B (CHB) infection is well established. However, the clinical
      implications of these proteins remain largely unknown. In this study,
      demographic, clinical, and laboratory data from 124,865 patients with chronic CHB
      infection were analyzed. Viral genotypes were determined by nested polymerase
      chain reaction. A chemiluminescent assay was applied to measure HBsAg, HBsAb,
      HBeAg, HBeAb, and HBcAb in sera. Among 124,865 patients with CHB infection, 324
      (0.3%) were concurrently positive for HBsAg and anti-HBs, and 206 (0.2%) were
      concurrently positive for HBeAg and anti-HBe. The HBeAg+/anti-HBe+ group was
      composed of younger patients (P &lt; 0.05). Subgenotype B2 was prevalent in HBV
      patients concurrently positive for HBeAg and anti-HBe, while HBV patients
      positive for both HBsAg and anti-HBs exhibited the C2 subgenotype. Among 530
      concurrent patients, 126 (39%) HBsAg+/anti-HBs+ patients were in the
      low-replication phase, and 62 (19%) were in the reactivation phase; 87 (42%)
      HBeAg+/anti-HBe+, and 19 (6%) HBsAg+/anti-HBs+ patients were in the immune
      clearance phase. In this large-scale analysis, the clinical and viral
      characteristics of HBV infections with concurrent HBs Ag/antibody or HBe
      Ag/antibody presentations have been examined, and the results may contribute to
      the diagnosis and treatment of CHB patients.
FAU - Xiang, Y
AU  - Xiang Y
FAU - Chen, P
AU  - Chen P
FAU - Xia, J R
AU  - Xia JR
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing
      Medical University, Yuzhong District, Chongqing, China.
FAU - Zhang, L P
AU  - Zhang LP
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing
      Medical University, Yuzhong District, Chongqing, China [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170223
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (DNA, Viral)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis B e Antigens)
SB  - IM
MH  - Adult
MH  - DNA, Viral/chemistry/genetics
MH  - Female
MH  - Genotype
MH  - Hepatitis B Antibodies/*blood/immunology
MH  - Hepatitis B Surface Antigens/*blood/immunology
MH  - Hepatitis B e Antigens/*blood/immunology
MH  - Hepatitis B virus/genetics/immunology/*physiology
MH  - Hepatitis B, Chronic/*blood/immunology/*virology
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Virus Activation/genetics
MH  - Virus Replication/genetics
MH  - Young Adult
EDAT- 2017/03/03 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/03 06:00
AID - gmr-16-01-gmr.16019102 [pii]
AID - 10.4238/gmr16019102 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Feb 23;16(1). doi: 10.4238/gmr16019102.

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