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Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population.

Abstract The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in a single ethnic population. Studies, published up to December 2015, were selected for the meta-analysis from PubMed and Chinese databases. The associations were assessed with pooled OR and 95%CI. This meta-analysis identified 8 studies, including 1276 periodontitis cases and 1558 controls. Overall, a significant association between the IL-1β C-511T polymorphism and periodontitis was found in the Chinese population (TT vs CC: OR = 1.48, 95%CI = 1.19-1.85; TT + CT vs CC: OR = 1.50, 95%CI = 1.25-1.81; T vs C: OR = 1.33, 95%CI = 1.06-1.68). In the subgroup analyses based on geographical area(s), source of controls, and type of periodontitis, significant results were obtained for the association between IL-1β C-511T variants and periodontitis. Our meta-analysis indicated that the IL-1β C-511T polymorphism may be a genetic susceptibility factor for periodontitis in the Chinese population. This marker could be used to identify Chinese individuals at a high risk for periodontitis.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title genetics and molecular research : gmr
Publication Year Start




PMID- 28252166
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170317
LR  - 20170317
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Feb 23
TI  - Association between the interleukin-1beta C-511T polymorphism and periodontitis: 
      a meta-analysis in the Chinese population.
LID - 10.4238/gmr16019315 [doi]
AB  - The association between the interleukin-1 beta (IL-1beta) C-511T (or rs16944)
      polymorphism and periodontitis remains inconclusive, even though there have been 
      previous studies on this association. To assess the effects of IL-1beta C-511T
      variants on the risk of development of periodontitis, a meta-analysis was
      performed in a single ethnic population. Studies, published up to December 2015, 
      were selected for the meta-analysis from PubMed and Chinese databases. The
      associations were assessed with pooled OR and 95%CI. This meta-analysis
      identified 8 studies, including 1276 periodontitis cases and 1558 controls.
      Overall, a significant association between the IL-1beta C-511T polymorphism and
      periodontitis was found in the Chinese population (TT vs CC: OR = 1.48, 95%CI =
      1.19-1.85; TT + CT vs CC: OR = 1.50, 95%CI = 1.25-1.81; T vs C: OR = 1.33, 95%CI 
      = 1.06-1.68). In the subgroup analyses based on geographical area(s), source of
      controls, and type of periodontitis, significant results were obtained for the
      association between IL-1beta C-511T variants and periodontitis. Our meta-analysis
      indicated that the IL-1beta C-511T polymorphism may be a genetic susceptibility
      factor for periodontitis in the Chinese population. This marker could be used to 
      identify Chinese individuals at a high risk for periodontitis.
FAU - Wang, H F
AU  - Wang HF
AD  - Department of Oral Medicine, Xiangya Hospital, Central South University,
      Changsha, China.
FAU - He, F Q
AU  - He FQ
AD  - Department of Prosthodontics, Changsha Stomatological Hospital, Changsha, China.
FAU - Xu, C J
AU  - Xu CJ
AD  - Department of Oral Medicine, Xiangya Hospital, Central South University,
      Changsha, China xyxucj77@126.com.
FAU - Li, D M
AU  - Li DM
AD  - Department of Oral Medicine, Xiangya Hospital, Central South University,
      Changsha, China.
FAU - Sun, X J
AU  - Sun XJ
AD  - Department of Oral Medicine, Xiangya Hospital, Central South University,
      Changsha, China.
FAU - Chi, Y T
AU  - Chi YT
AD  - Department of Oral Medicine, Xiangya Hospital, Central South University,
      Changsha, China.
FAU - Guo, W
AU  - Guo W
AD  - Department of Pathology, Xiangya Hospital, Central South University, Changsha,
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170223
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Interleukin-1beta)
SB  - IM
MH  - Asian Continental Ancestry Group/genetics
MH  - China
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-1beta/*genetics
MH  - Linkage Disequilibrium
MH  - Odds Ratio
MH  - Periodontitis/ethnology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2017/03/03 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/03 06:00
AID - gmr-16-01-gmr.16019315 [pii]
AID - 10.4238/gmr16019315 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Feb 23;16(1). doi: 10.4238/gmr16019315.

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