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Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine Models of Inflammatory Bowel Disease (IBD).

Abstract Inflammatory bowel disease (IBD) is a chronic multifactorial inflammatory disorder characterized by periods of activation and remission of intestinal inflammation, with potentially severe complications, that can lead to mortality. Experimental animal models of intestinal inflammation are crucial for understanding the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), the two major human IBD phenotypes. Animal models have been instrumental in unveiling the molecular background of IBD, and although a single model is not able to capture the complexity of this disease, each of them provided valuable insight into its different aspects. Chemically induced models of intestinal inflammation, mainly dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, are widely used. This article describes DSS- and TNBS-induced colitis models and their relevance to IBD pathophysiology and pre-clinical therapeutic management. © 2017 by John Wiley & Sons, Inc.
PMID
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Authors

Mayor MeshTerms

Disease Models, Animal

Keywords

2,4,6-trinitrobenzenesulfonic acid

animal models

inflammatory bowel disease

sodium dextran sulfate

Journal Title current protocols in mouse biology
Publication Year Start




PMID- 28252200
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170317
LR  - 20170317
IS  - 2161-2617 (Electronic)
IS  - 2161-2617 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Mar 02
TI  - Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine
      Models of Inflammatory Bowel Disease (IBD).
PG  - 13-28
LID - 10.1002/cpmo.20 [doi]
AB  - Inflammatory bowel disease (IBD) is a chronic multifactorial inflammatory
      disorder characterized by periods of activation and remission of intestinal
      inflammation, with potentially severe complications, that can lead to mortality. 
      Experimental animal models of intestinal inflammation are crucial for
      understanding the pathogenesis of Crohn's disease (CD) and ulcerative colitis
      (UC), the two major human IBD phenotypes. Animal models have been instrumental in
      unveiling the molecular background of IBD, and although a single model is not
      able to capture the complexity of this disease, each of them provided valuable
      insight into its different aspects. Chemically induced models of intestinal
      inflammation, mainly dextran sodium sulfate (DSS)- and
      2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, are widely used. This 
      article describes DSS- and TNBS-induced colitis models and their relevance to IBD
      pathophysiology and pre-clinical therapeutic management. (c) 2017 by John Wiley &
      Sons, Inc.
CI  - Copyright (c) 2017 John Wiley & Sons, Inc.
FAU - Gadaleta, Raffaella Maria
AU  - Gadaleta RM
AD  - Interdisciplinary Department of Medicine, University of Bari, Bari, Italy.
AD  - Department of Surgery and Cancer, Hammersmith Hospital, Imperial College, London,
      United Kingdom.
AD  - Istituto Nazionale Biostrutture e Biosistemi (INBB), Rome, Italy.
FAU - Garcia-Irigoyen, Oihane
AU  - Garcia-Irigoyen O
AD  - Interdisciplinary Department of Medicine, University of Bari, Bari, Italy.
FAU - Moschetta, Antonio
AU  - Moschetta A
AD  - Interdisciplinary Department of Medicine, University of Bari, Bari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - United States
TA  - Curr Protoc Mouse Biol
JT  - Current protocols in mouse biology
JID - 101560384
RN  - 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - MO0N1J0SEN (Azoxymethane)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Azoxymethane
MH  - Cell Transformation, Neoplastic/*chemically induced
MH  - Chronic Disease
MH  - Colitis/*chemically induced
MH  - Dextran Sulfate
MH  - *Disease Models, Animal
MH  - Humans
MH  - Inflammatory Bowel Diseases/*chemically induced
MH  - Mice
MH  - Trinitrobenzenesulfonic Acid
OTO - NOTNLM
OT  - 2,4,6-trinitrobenzenesulfonic acid
OT  - animal models
OT  - inflammatory bowel disease
OT  - sodium dextran sulfate
EDAT- 2017/03/03 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/03 06:00
AID - 10.1002/cpmo.20 [doi]
PST - epublish
SO  - Curr Protoc Mouse Biol. 2017 Mar 2;7(1):13-28. doi: 10.1002/cpmo.20.

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