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A Mouse Model for Ocular Surface Staphylococcus aureus Infection.

Abstract Creation of an appropriate animal model that accurately reflects the disease and host immune response to bacterial infection in humans is a major challenge in ocular-surface infection research. For decades, mice have been the ideal small animal model for ocular-surface infection research because of the availability and relatively low cost of various genetic backgrounds, targeted defects, and immunologic reagents. By employing different combinations of mouse and bacterial strains, murine infection models can be used to explore a complete picture of bacterial infection and innate immunity of the ocular surface. A murine model of Staphylococcus aureus infection under normal ocular circumstances is presented here as a convenient and tractable model system in which to study mammalian host responses to pathogens. © 2017 by John Wiley & Sons, Inc.
PMID
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Authors

Mayor MeshTerms

Disease Models, Animal

Keywords

Staphylococcus aureus, host defense

cornea

eye

infection

Journal Title current protocols in mouse biology
Publication Year Start




PMID- 28252202
OWN - NLM
STAT- MEDLINE
DA  - 20170302
DCOM- 20170317
LR  - 20170317
IS  - 2161-2617 (Electronic)
IS  - 2161-2617 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Mar 02
TI  - A Mouse Model for Ocular Surface Staphylococcus aureus Infection.
PG  - 55-63
LID - 10.1002/cpmo.23 [doi]
AB  - Creation of an appropriate animal model that accurately reflects the disease and 
      host immune response to bacterial infection in humans is a major challenge in
      ocular-surface infection research. For decades, mice have been the ideal small
      animal model for ocular-surface infection research because of the availability
      and relatively low cost of various genetic backgrounds, targeted defects, and
      immunologic reagents. By employing different combinations of mouse and bacterial 
      strains, murine infection models can be used to explore a complete picture of
      bacterial infection and innate immunity of the ocular surface. A murine model of 
      Staphylococcus aureus infection under normal ocular circumstances is presented
      here as a convenient and tractable model system in which to study mammalian host 
      responses to pathogens. (c) 2017 by John Wiley & Sons, Inc.
CI  - Copyright (c) 2017 John Wiley & Sons, Inc.
FAU - Zhang, Zhiyong
AU  - Zhang Z
AD  - Department of Surgery, The State University of New York Upstate Medical
      University, Syracuse, New York.
AD  - Department of Ophthalmology, Zhejiang Medical College Affiliated Zhejiang
      Hospital, Hangzhou, Zhejiang, People's Republic of China.
FAU - Abdel-Razek, Osama
AU  - Abdel-Razek O
AD  - Department of Surgery, The State University of New York Upstate Medical
      University, Syracuse, New York.
FAU - Wang, Guirong
AU  - Wang G
AD  - Department of Surgery, The State University of New York Upstate Medical
      University, Syracuse, New York.
LA  - eng
GR  - R21 HL096007/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170302
PL  - United States
TA  - Curr Protoc Mouse Biol
JT  - Current protocols in mouse biology
JID - 101560384
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Epithelial Cells/immunology/*microbiology
MH  - Eye Infections/immunology/*microbiology
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
MH  - Immunity, Innate/immunology/physiology
MH  - Mice
MH  - Neutrophils/immunology/physiology
MH  - Phagocytosis/immunology/physiology
MH  - Staphylococcal Infections/immunology/*microbiology
MH  - Staphylococcus aureus/immunology/*physiology
MH  - Surface Properties
PMC - PMC5334776
MID - NIHMS832524
OTO - NOTNLM
OT  - Staphylococcus aureus, host defense
OT  - cornea
OT  - eye
OT  - infection
EDAT- 2017/03/03 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/03 06:00
PMCR- 2018/03/02
AID - 10.1002/cpmo.23 [doi]
PST - epublish
SO  - Curr Protoc Mouse Biol. 2017 Mar 2;7(1):55-63. doi: 10.1002/cpmo.23.

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