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Association of MAP4K4 gene single nucleotide polymorphism with mastitis and milk traits in Chinese Holstein cattle.

Abstract The objective of the studies presented in this Research Communication was to investigate the association of single nucleotide polymorphisms present in the MAP4K4 gene with different milk traits in dairy cows. Based on previous QTL fine mapping results on bovine chromosome 11, the MAP4K4 gene was selected as a candidate gene to evaluate its effect on somatic cell count and milk traits in ChineseHolstein cows. Milk production traits including milk yield, fat percentage, and protein percentage of each cow were collected using 305 d lactation records. Association between MAP4K4 genotype and different traits and Somatic Cell Score (SCS) was performed using General Linear Regression Model of R. Two SNPs at exon 18 (c.2061T > G and c.2196T > C) with genotype TT in both SNPs were found significantly higher for somatic SCS. We found the significant effect of exon 18 (c.2061T > G) on protein percentage, milk yield and SCS. We identified SNPs at different location of MAP4K4 gene of the cattle and several of them were significantly associated with the somatic cell score and other different milk traits. Thus, MAP4K4 gene could be a useful candidate gene for selection of dairy cattle against mastitis and the identified polymorphisms might potentially be strong genetic markers.
PMID
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Authors

Mayor MeshTerms
Keywords

MAP4K4

mastitis

polymorphism

somatic cell scores

Journal Title the journal of dairy research
Publication Year Start




PMID- 28252361
OWN - NLM
STAT- In-Process
DA  - 20170302
LR  - 20170302
IS  - 1469-7629 (Electronic)
IS  - 0022-0299 (Linking)
VI  - 84
IP  - 1
DP  - 2017 Feb
TI  - Association of MAP4K4 gene single nucleotide polymorphism with mastitis and milk 
      traits in Chinese Holstein cattle.
PG  - 76-79
LID - 10.1017/S0022029916000832 [doi]
AB  - The objective of the studies presented in this Research Communication was to
      investigate the association of single nucleotide polymorphisms present in the
      MAP4K4 gene with different milk traits in dairy cows. Based on previous QTL fine 
      mapping results on bovine chromosome 11, the MAP4K4 gene was selected as a
      candidate gene to evaluate its effect on somatic cell count and milk traits in
      ChineseHolstein cows. Milk production traits including milk yield, fat
      percentage, and protein percentage of each cow were collected using 305 d
      lactation records. Association between MAP4K4 genotype and different traits and
      Somatic Cell Score (SCS) was performed using General Linear Regression Model of
      R. Two SNPs at exon 18 (c.2061T > G and c.2196T > C) with genotype TT in both
      SNPs were found significantly higher for somatic SCS. We found the significant
      effect of exon 18 (c.2061T > G) on protein percentage, milk yield and SCS. We
      identified SNPs at different location of MAP4K4 gene of the cattle and several of
      them were significantly associated with the somatic cell score and other
      different milk traits. Thus, MAP4K4 gene could be a useful candidate gene for
      selection of dairy cattle against mastitis and the identified polymorphisms might
      potentially be strong genetic markers.
FAU - Bhattarai, Dinesh
AU  - Bhattarai D
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Chen, Xing
AU  - Chen X
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Ur Rehman, Zia
AU  - Ur Rehman Z
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Hao, Xingjie
AU  - Hao X
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Ullah, Farman
AU  - Ullah F
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Dad, Rahim
AU  - Dad R
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Talpur, Hira Sajjad
AU  - Talpur HS
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Kadariya, Ishwari
AU  - Kadariya I
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Cui, Lu
AU  - Cui L
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
FAU - Fan, Mingxia
AU  - Fan M
AD  - Renmin Hospital of Wuhan University,Wuhan 430060,People's Republic of China.
FAU - Zhang, Shujun
AU  - Zhang S
AD  - Key Laboratory of Agricultural Animal Genetics,Breeding and
      Reproduction,Education Ministry of China,College of Animal Science and
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of
      China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Dairy Res
JT  - The Journal of dairy research
JID - 2985125R
OTO - NOTNLM
OT  - MAP4K4
OT  - mastitis
OT  - polymorphism
OT  - somatic cell scores
EDAT- 2017/03/03 06:00
MHDA- 2017/03/03 06:00
CRDT- 2017/03/03 06:00
AID - S0022029916000832 [pii]
AID - 10.1017/S0022029916000832 [doi]
PST - ppublish
SO  - J Dairy Res. 2017 Feb;84(1):76-79. doi: 10.1017/S0022029916000832.

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