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Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.

Abstract Recurrence and metastasis are the usual manifestations of treatment failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predictive factors for metastasis and prognosis in various cancers. In this study, we analyzed associations among VM, ALDH1, KiSS-1, and MACC1 in EOC, and their respective correlations with clinicopathological characteristics and survival in EOC.
PMID
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Authors

Mayor MeshTerms
Keywords

ALDH1

Epithelial ovarian carcinoma

KiSS-1

MACC1

Prognosis

VM

Journal Title diagnostic pathology
Publication Year Start




PMID- 28253891
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170313
LR  - 20170313
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Mar 02
TI  - Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1
      in the prediction of metastasis and prognosis in ovarian carcinoma.
PG  - 23
LID - 10.1186/s13000-017-0612-9 [doi]
AB  - BACKGROUND: Recurrence and metastasis are the usual manifestations of treatment
      failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood
      supply development often seen in highly aggressive cancers), aldehyde
      dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor 
      metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful
      predictive factors for metastasis and prognosis in various cancers. In this
      study, we analyzed associations among VM, ALDH1, KiSS-1, and MACC1 in EOC, and
      their respective correlations with clinicopathological characteristics and
      survival in EOC. METHODS: Positive rates of VM, ALDH1, KiSS-1, and MACC1 in 207
      whole EOC tissue samples were detected by immunohistochemistry. Patients'
      clinical data were also collected. RESULTS: Levels of VM, ALDH1, and MACC1 were
      significantly higher, and levels of KiSS-1 significantly lower, in EOC tissues
      than in benign ovary tumors. Levels of VM, ALDH1, KiSS-1, and MACC1 were
      associated significantly with tumor/lymph node/metastasis (LNM) grade,
      implantation, and International Federation of Gynecology and Obstetrics (FIGO)
      stage, and with patients' overall survival (OS); whereas the KiSS-1+ subgroup had
      significantly longer OS than did the KiSS-1- subgroup. In multivariate analysis, 
      high VM, ALDH1 or MACC1 levels, FIGO stage, implantation and low KiSS-1 levels
      were independently associated with shorter OS in patients with EOC. CONCLUSIONS: 
      VM and expressions of ALDH1, KiSS-1, and MACC1 represent promising markers for
      metastasis and prognosis, and potential therapeutic targets for EOC.
FAU - Yu, Lan
AU  - Yu L
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
FAU - Zhu, Bo
AU  - Zhu B
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
FAU - Wu, Shiwu
AU  - Wu S
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China. [email protected]
FAU - Zhou, Lei
AU  - Zhou L
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
FAU - Song, Wenqing
AU  - Song W
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
FAU - Gong, Xiaomeng
AU  - Gong X
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
FAU - Wang, Danna
AU  - Wang D
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College,
      Bengbu Medical College, No.287, Changhuai Road, Bengbu, 233003, Anhui Province,
      China.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Isoenzymes)
RN  - 0 (KISS1 protein, human)
RN  - 0 (Kisspeptins)
RN  - 0 (MACC1 protein, human)
RN  - 0 (Transcription Factors)
RN  - EC 1.2.1.- (aldehyde dehydrogenase 1)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma/blood supply/*diagnosis/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Isoenzymes/metabolism
MH  - Kisspeptins/metabolism
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Ovarian Neoplasms/blood supply/*diagnosis/metabolism/pathology
MH  - Ovary/metabolism/pathology
MH  - Prognosis
MH  - Retinal Dehydrogenase/metabolism
MH  - Transcription Factors/metabolism
MH  - Young Adult
PMC - PMC5335811
OTO - NOTNLM
OT  - ALDH1
OT  - Epithelial ovarian carcinoma
OT  - KiSS-1
OT  - MACC1
OT  - Prognosis
OT  - VM
EDAT- 2017/03/04 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/09/16 [received]
PHST- 2017/02/20 [accepted]
AID - 10.1186/s13000-017-0612-9 [doi]
AID - 10.1186/s13000-017-0612-9 [pii]
PST - epublish
SO  - Diagn Pathol. 2017 Mar 2;12(1):23. doi: 10.1186/s13000-017-0612-9.

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