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ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.

Abstract The occurrence of more than 200 diseases, including cancer, can be attributed to alcohol drinking. The global cancer deaths attributed to alcohol-consumption rose from 243,000 in 1990 to 337,400 in 2010. In 2010, cancer deaths due to alcohol consumption accounted for 4.2% of all cancer deaths. Strong epidemiological evidence has established the causal role of alcohol in the development of various cancers, including esophageal cancer, head and neck cancer, liver cancer, breast cancer, and colorectal cancer. The evidence for the association between alcohol and other cancers is inconclusive. Because of the high prevalence of ALDH2*2 allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of esophageal cancer and head and neck cancer, while data for other cancers are more limited. The high prevalence of ALDH2*2 allele in East Asian populations may have important public health implications and may be utilized to reduce the occurrence of alcohol-related cancers among East Asians, including: 1) Identification of individuals at high risk of developing alcohol-related cancers by screening for ALDH2 polymorphism; 2) Incorporation of ALDH2 polymorphism screening into behavioral intervention program for promoting alcohol abstinence or reducing alcohol consumption; 3) Using ALDH2 polymorphism as a prognostic indicator for alcohol-related cancers; 4) Targeting ALDH2 for chemoprevention; and 5) Setting guidelines for alcohol consumption among ALDH2 deficient individuals. Future studies should evaluate whether these strategies are effective for preventing the occurrence of alcohol-related cancers.
PMID
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Authors

Mayor MeshTerms

Alleles

Polymorphism, Genetic

Keywords

Alcohol

Aldehyde dehydrogenase 2

Cancer

Prevention

Public health

Journal Title journal of biomedical science
Publication Year Start




PMID- 28253921
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170310
LR  - 20170310
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Mar 03
TI  - ALDH2 polymorphism and alcohol-related cancers in Asians: a public health
      perspective.
PG  - 19
LID - 10.1186/s12929-017-0327-y [doi]
AB  - The occurrence of more than 200 diseases, including cancer, can be attributed to 
      alcohol drinking. The global cancer deaths attributed to alcohol-consumption rose
      from 243,000 in 1990 to 337,400 in 2010. In 2010, cancer deaths due to alcohol
      consumption accounted for 4.2% of all cancer deaths. Strong epidemiological
      evidence has established the causal role of alcohol in the development of various
      cancers, including esophageal cancer, head and neck cancer, liver cancer, breast 
      cancer, and colorectal cancer. The evidence for the association between alcohol
      and other cancers is inconclusive. Because of the high prevalence of ALDH2*2
      allele among East Asian populations, East Asians may be more susceptible to the
      carcinogenic effect of alcohol, with most evidence coming from studies of
      esophageal cancer and head and neck cancer, while data for other cancers are more
      limited. The high prevalence of ALDH2*2 allele in East Asian populations may have
      important public health implications and may be utilized to reduce the occurrence
      of alcohol-related cancers among East Asians, including: 1) Identification of
      individuals at high risk of developing alcohol-related cancers by screening for
      ALDH2 polymorphism; 2) Incorporation of ALDH2 polymorphism screening into
      behavioral intervention program for promoting alcohol abstinence or reducing
      alcohol consumption; 3) Using ALDH2 polymorphism as a prognostic indicator for
      alcohol-related cancers; 4) Targeting ALDH2 for chemoprevention; and 5) Setting
      guidelines for alcohol consumption among ALDH2 deficient individuals. Future
      studies should evaluate whether these strategies are effective for preventing the
      occurrence of alcohol-related cancers.
FAU - Chang, Jeffrey S
AU  - Chang JS
AD  - National Institute of Cancer Research, National Health Research Institutes, 1F.
      No 367, Sheng-Li Road, Tainan, 70456, Taiwan. [email protected]
FAU - Hsiao, Jenn-Ren
AU  - Hsiao JR
AD  - Department of Otolaryngology, National Cheng Kung University Hospital, College of
      Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456,
      Taiwan.
FAU - Chen, Che-Hong
AU  - Chen CH
AD  - Department of Chemical and Systems Biology, Stanford University, School of
      Medicine, 269 Campus Drive, CCSR Building, Rm. 3140, Stanford, CA, 94305, USA.
      [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170303
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - EC 1.2.1.3 (ALDH2 protein, human)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase, Mitochondrial)
SB  - IM
MH  - Alcohol-Related Disorders/enzymology/epidemiology/*genetics/prevention & control
MH  - Aldehyde Dehydrogenase, Mitochondrial/*genetics
MH  - *Alleles
MH  - Asian Continental Ancestry Group
MH  - Esophageal Neoplasms/enzymology/epidemiology/*genetics/prevention & control
MH  - Far East
MH  - Head and Neck Neoplasms/enzymology/epidemiology/*genetics/prevention & control
MH  - Humans
MH  - *Polymorphism, Genetic
PMC - PMC5335829
OTO - NOTNLM
OT  - Alcohol
OT  - Aldehyde dehydrogenase 2
OT  - Cancer
OT  - Prevention
OT  - Public health
EDAT- 2017/03/04 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/10/19 [received]
PHST- 2017/02/26 [accepted]
AID - 10.1186/s12929-017-0327-y [doi]
AID - 10.1186/s12929-017-0327-y [pii]
PST - epublish
SO  - J Biomed Sci. 2017 Mar 3;24(1):19. doi: 10.1186/s12929-017-0327-y.

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