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Withania somnifera leaf alleviates cognitive dysfunction by enhancing hippocampal plasticity in high fat diet induced obesity model.

Abstract Sedentary lifestyle, psychological stress and labor saving devices in this current society often disrupts the energy gain and expenditure balance leading to obesity. High caloric diet is associated with the high prevalence of cognitive dysfunction and neuropsychiatric disorders in addition to cardiovascular and metabolic abnormalities. The present study was aimed to elucidate the potential beneficial effect of dry leaf powder of Withania somnifera (Ashwagandha) in preventing the cognitive decline associated with diet induced obesity.
PMID
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Authors

Mayor MeshTerms
Keywords

Ashwagandha

Cognition

Neuroprotection

Obesity

Synaptic plasticity

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28253924
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170313
LR  - 20170313
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 03
TI  - Withania somnifera leaf alleviates cognitive dysfunction by enhancing hippocampal
      plasticity in high fat diet induced obesity model.
PG  - 136
LID - 10.1186/s12906-017-1652-0 [doi]
AB  - BACKGROUND: Sedentary lifestyle, psychological stress and labor saving devices in
      this current society often disrupts the energy gain and expenditure balance
      leading to obesity. High caloric diet is associated with the high prevalence of
      cognitive dysfunction and neuropsychiatric disorders in addition to
      cardiovascular and metabolic abnormalities. The present study was aimed to
      elucidate the potential beneficial effect of dry leaf powder of Withania
      somnifera (Ashwagandha) in preventing the cognitive decline associated with diet 
      induced obesity. METHODS: Experiments were performed on four groups of young
      adult female rats: [Low fat diet (LFD) rats fed on regular low fat chow, High fat
      diet (HFD) rats on feed containing 30% fat by weight, Low fat diet extract (LFDE)
      rats given regular chow and dry leaf powder of Ashwagandha 1 mg/g of body weight 
      (ASH) and high fat diet extract (HFDE) rats fed on diet containing high fat and
      dry leaf powder of ASH. All the rats were kept on their respective diet regimen
      for 12 weeks. RESULTS: ASH treated rats showed significant improvement in their
      working memory and locomotor coordination during behavioral studies as compared
      to HFD rats. At the molecular level, ASH treatment was observed to restore the
      levels of BDNF and its receptor TRKB as well as the expression of other synaptic 
      regulators, which are highly implicated in synaptic plasticity. Further, ASH
      triggered the activation of PI3/AKT pathway of cell survival and plasticity by
      enhancing the levels of phosphorylated Akt-1 and immediate early genes viz. c-Jun
      and c-fos. CONCLUSIONS: ASH could be a key regulator in maintaining the synaptic 
      plasticity in HFD induced obesity and can serve as a nootropic candidate against 
      obesity induced cognitive impairments.
FAU - Manchanda, Shaffi
AU  - Manchanda S
AD  - Medical Biotechnology Laboratory, Department of Biotechnology, Guru Nanak Dev
      University, Amritsar, 143005, Punjab, India.
FAU - Kaur, Gurcharan
AU  - Kaur G
AD  - Medical Biotechnology Laboratory, Department of Biotechnology, Guru Nanak Dev
      University, Amritsar, 143005, Punjab, India. kgurcharan.neuro@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Adrenal Cortex Hormones/blood
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Cognitive Dysfunction/etiology/*therapy
MH  - Diet, High-Fat
MH  - Female
MH  - Hippocampus/*drug effects
MH  - Neuronal Plasticity
MH  - Obesity/*complications
MH  - Plant Leaves
MH  - Plant Preparations/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Withania/*chemistry
PMC - PMC5335828
OTO - NOTNLM
OT  - Ashwagandha
OT  - Cognition
OT  - Neuroprotection
OT  - Obesity
OT  - Synaptic plasticity
EDAT- 2017/03/04 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/11/05 [received]
PHST- 2017/02/24 [accepted]
AID - 10.1186/s12906-017-1652-0 [doi]
AID - 10.1186/s12906-017-1652-0 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Mar 3;17(1):136. doi: 10.1186/s12906-017-1652-0.

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