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Associations of Adenovirus Genotypes in Korean Acute Gastroenteritis Patients with Respiratory Symptoms and Intussusception.

Abstract Human adenoviruses (HAdVs) cause a wide range of diseases, including respiratory infections and gastroenteritis, and have more than 65 genotypes. To investigate the current genotypes of circulating HAdV strains, we performed molecular genotyping of HAdVs in the stool from patients with acute gastroenteritis and tried to determine their associations with clinical symptoms. From June 2014 to May 2016, 3,901 fecal samples were tested for an AdV antigen, and 254 samples (6.5%) yielded positive results. Genotyping using PCR and sequencing of the capsid hexon gene was performed for 236‚ÄČAdV antigen-positive fecal specimens. HAdV-41, of species F, was the most prevalent genotype (60.6%), followed by HAdV-2 of species C (13.8%). Other genotypes, including HAdV-3, HAdV-1, HAdV-5, HAdV-6, HAdV-31, HAdV-40, HAdV-12, and HAdV-55, were also detected. Overall, 119 patients (50.4%) showed concomitant respiratory symptoms, and 32 patients (13.6%) were diagnosed with intussusception. HAdV-1 and HAdV-31 were significantly associated with intussusception (P < 0.05). Our results demonstrate the recent changes in trends of circulating AdV genotypes associated with gastroenteritis in Korea, which should be of value for improving the diagnosis and developing new detection, treatment, and prevention strategies for broad application in clinical laboratories.
PMID
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Authors

Mayor MeshTerms

Asian Continental Ancestry Group

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28255553
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170313
LR  - 20170313
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Associations of Adenovirus Genotypes in Korean Acute Gastroenteritis Patients
      with Respiratory Symptoms and Intussusception.
PG  - 1602054
LID - 10.1155/2017/1602054 [doi]
AB  - Human adenoviruses (HAdVs) cause a wide range of diseases, including respiratory 
      infections and gastroenteritis, and have more than 65 genotypes. To investigate
      the current genotypes of circulating HAdV strains, we performed molecular
      genotyping of HAdVs in the stool from patients with acute gastroenteritis and
      tried to determine their associations with clinical symptoms. From June 2014 to
      May 2016, 3,901 fecal samples were tested for an AdV antigen, and 254 samples
      (6.5%) yielded positive results. Genotyping using PCR and sequencing of the
      capsid hexon gene was performed for 236 AdV antigen-positive fecal specimens.
      HAdV-41, of species F, was the most prevalent genotype (60.6%), followed by
      HAdV-2 of species C (13.8%). Other genotypes, including HAdV-3, HAdV-1, HAdV-5,
      HAdV-6, HAdV-31, HAdV-40, HAdV-12, and HAdV-55, were also detected. Overall, 119 
      patients (50.4%) showed concomitant respiratory symptoms, and 32 patients (13.6%)
      were diagnosed with intussusception. HAdV-1 and HAdV-31 were significantly
      associated with intussusception (P &lt; 0.05). Our results demonstrate the recent
      changes in trends of circulating AdV genotypes associated with gastroenteritis in
      Korea, which should be of value for improving the diagnosis and developing new
      detection, treatment, and prevention strategies for broad application in clinical
      laboratories.
FAU - Kim, Jae-Seok
AU  - Kim JS
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Lee, Su Kyung
AU  - Lee SK
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Ko, Dae-Hyun
AU  - Ko DH
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Hyun, Jungwon
AU  - Hyun J
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Kim, Han-Sung
AU  - Kim HS
AUID- ORCID: 0000-0002-5481-5390
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Song, Wonkeun
AU  - Song W
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
FAU - Kim, Hyun Soo
AU  - Kim HS
AUID- ORCID: 0000-0002-7026-6715
AD  - Department of Laboratory Medicine, Hallym University College of Medicine,
      Hwaseong, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170201
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Acute Disease
MH  - Adenoviridae Infections/*complications/virology
MH  - Adenoviruses, Human/*genetics
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asian Continental Ancestry Group
MH  - Child
MH  - Child, Preschool
MH  - Feces/virology
MH  - Gastroenteritis/complications/*virology
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intussusception/*complications/virology
MH  - Middle Aged
MH  - Respiratory Tract Infections/*complications/virology
MH  - Viral Load
MH  - Young Adult
PMC - PMC5309414
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/04 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/09/18 [received]
PHST- 2016/12/16 [revised]
PHST- 2016/12/27 [accepted]
AID - 10.1155/2017/1602054 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:1602054. doi: 10.1155/2017/1602054. Epub 2017 Feb 1.

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