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Cutaneous side-effects of biologics in immune-mediated disorders: A histopathological perspective.

Abstract Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.
PMID
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Authors

Mayor MeshTerms
Keywords

biologics

drug reactions

lichen planus

psoriasis

tumor necrosis factor-α inhibitors

Journal Title the journal of dermatology
Publication Year Start


 


PMID- 28256759
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170306
LR  - 20170306
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 3
DP  - 2017 Mar
TI  - Cutaneous side-effects of biologics in immune-mediated disorders: A
      histopathological perspective.
PG  - 243-250
LID - 10.1111/1346-8138.13762 [doi]
AB  - Advances in understanding molecular mechanisms and targets in immune regulation
      have led to the widespread use of biologic targeted therapies, and, as such,
      reformed the course of many disabling diseases. However, with their expanded use,
      various side-effects, including cutaneous, have emerged. Many times a clear-cut
      relationship exists between the drug and the clinical manifestations; however,
      when a biopsy is warranted, various histopathological patterns may be observed
      and may cause confusion to the dermatopathologist. The aim of this review is to
      shed light on the different histopathological patterns observed as a
      manifestation secondary to biologics.
CI  - (c) 2017 Japanese Dermatological Association.
FAU - Succaria, Farah
AU  - Succaria F
AD  - Section of Dermatopathology, Department of Dermatology, Boston University School 
      of Medicine, Boston, Massachusetts, USA.
FAU - Bhawan, Jag
AU  - Bhawan J
AD  - Section of Dermatopathology, Department of Dermatology, Boston University School 
      of Medicine, Boston, Massachusetts, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
SB  - IM
MH  - Antibodies, Monoclonal/adverse effects/therapeutic use
MH  - Antirheumatic Agents/adverse effects/therapeutic use
MH  - Biological Products/*adverse effects/therapeutic use
MH  - Humans
MH  - Immune System Diseases/therapy
MH  - Skin Diseases/etiology/*pathology
OTO - NOTNLM
OT  - biologics
OT  - drug reactions
OT  - lichen planus
OT  - psoriasis
OT  - tumor necrosis factor-alpha inhibitors
EDAT- 2017/03/04 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/12/05 [received]
PHST- 2016/12/07 [accepted]
AID - 10.1111/1346-8138.13762 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Mar;44(3):243-250. doi: 10.1111/1346-8138.13762.

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