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What is new in the histogenesis of granulomatous skin diseases?

Abstract A granuloma is a form of inflammation, which predominantly consists of macrophages. It typically develops when the immune system attempts to enclose substances that are usually insoluble and cannot be eliminated to prevent the spread of these substances to the other body compartments. According to the source of the substances, granulomatous diseases can be divided into two groups: infectious and non-infectious. The mechanisms of infectious granuloma formation have been widely investigated because of its easy reproducibility in experimental models, both in vivo and in vitro. On the contrary, mechanisms of non-infectious granuloma formation have not been well investigated because of the difficulty to reproduce this formation in experimental models. In this article, we review our recent understanding of the histogenesis and pathogenesis of granuloma formation, confirmed from studies of infectious granulomas, and we present potential hypotheses of the histogenesis and pathogenesis of non-infectious granulomas based on clinical investigations.
PMID
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Authors

Mayor MeshTerms
Keywords

granuloma

granuloma annulare

macrophage polarization

necrobiosis lipoidica

sarcoidosis

Journal Title the journal of dermatology
Publication Year Start




PMID- 28256762
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170306
LR  - 20170306
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 3
DP  - 2017 Mar
TI  - What is new in the histogenesis of granulomatous skin diseases?
PG  - 297-303
LID - 10.1111/1346-8138.13662 [doi]
AB  - A granuloma is a form of inflammation, which predominantly consists of
      macrophages. It typically develops when the immune system attempts to enclose
      substances that are usually insoluble and cannot be eliminated to prevent the
      spread of these substances to the other body compartments. According to the
      source of the substances, granulomatous diseases can be divided into two groups: 
      infectious and non-infectious. The mechanisms of infectious granuloma formation
      have been widely investigated because of its easy reproducibility in experimental
      models, both in vivo and in vitro. On the contrary, mechanisms of non-infectious 
      granuloma formation have not been well investigated because of the difficulty to 
      reproduce this formation in experimental models. In this article, we review our
      recent understanding of the histogenesis and pathogenesis of granuloma formation,
      confirmed from studies of infectious granulomas, and we present potential
      hypotheses of the histogenesis and pathogenesis of non-infectious granulomas
      based on clinical investigations.
CI  - (c) 2017 Japanese Dermatological Association.
FAU - Asai, Jun
AU  - Asai J
AD  - Department of Dermatology, Kyoto prefectural University of Medicine, Graduate
      School of Medical Science, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
SB  - IM
MH  - Dermatitis/immunology/pathology
MH  - Granuloma/immunology/*pathology
MH  - Granuloma Annulare/immunology/pathology
MH  - Humans
MH  - Macrophages/*immunology
MH  - Necrobiosis Lipoidica/immunology/pathology
MH  - Sarcoidosis/immunology/pathology
MH  - Skin Diseases/immunology/*pathology
OTO - NOTNLM
OT  - granuloma
OT  - granuloma annulare
OT  - macrophage polarization
OT  - necrobiosis lipoidica
OT  - sarcoidosis
EDAT- 2017/03/04 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/09/13 [received]
PHST- 2016/09/14 [accepted]
AID - 10.1111/1346-8138.13662 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Mar;44(3):297-303. doi: 10.1111/1346-8138.13662.

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