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Topics in histopathology of sweat gland and sebaceous neoplasms.

Abstract This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC(+) , SMBC(-) ), CK5/6 (SGC(+) , SMBC(-) ), podoplanin (SGC(+) , SMBC(-) ) and mammaglobin (SGC(-) , SMBC(+) ). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and ZEB2/SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC is rare, especially extraocular SC, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive SC. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well-defined architecture and no atypia), borderline sebaceous neoplasm (low-grade SC; an intermediate tumor with well-defined architecture and nuclear atypia) and SC (a malignant tumor with invasive growth and evident nuclear atypia).
PMID
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Authors

Mayor MeshTerms
Keywords

borderline sebaceous neoplasm

immunohistochemistry

poroid neoplasm

sebaceous tumor

sweat gland tumor

Journal Title the journal of dermatology
Publication Year Start




PMID- 28256768
OWN - NLM
STAT- MEDLINE
DA  - 20170303
DCOM- 20170306
LR  - 20170306
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 3
DP  - 2017 Mar
TI  - Topics in histopathology of sweat gland and sebaceous neoplasms.
PG  - 315-326
LID - 10.1111/1346-8138.13555 [doi]
AB  - This article reviews several topics regarding sweat gland and sebaceous
      neoplasms. First, the clinicopathological characteristics of poroid neoplasms are
      summarized. It was recently reported that one-fourth of poroid neoplasms are
      composite tumors and one-fourth are apocrine type lesions. Recent progress in the
      immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117
      can help to distinguish sweat gland or sebaceous tumors from other non-Merkel
      cell epithelial tumors of the skin. For immunohistochemical differential
      diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous
      apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of
      antibodies may be useful, including p63 (SGC+ , SMBC- ), CK5/6 (SGC+ , SMBC- ),
      podoplanin (SGC+ , SMBC- ) and mammaglobin (SGC- , SMBC+ ). Comparison of
      antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC)
      suggests that adipophilin has the highest sensitivity and specificity. Some
      authors have found that immunostaining for survivin, androgen receptor and
      ZEB2/SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC 
      is rare, especially extraocular SC, but there have been several recent reports
      that actinic keratosis and Bowen's disease are the source of invasive SC.
      Finally, based on recent reports, classification of sebaceous neoplasms into
      three categories is proposed, which are sebaceoma (a benign neoplasm with
      well-defined architecture and no atypia), borderline sebaceous neoplasm
      (low-grade SC; an intermediate tumor with well-defined architecture and nuclear
      atypia) and SC (a malignant tumor with invasive growth and evident nuclear
      atypia).
CI  - (c) 2017 Japanese Dermatological Association.
FAU - Ansai, Shin-Ichi
AU  - Ansai SI
AD  - Division of Dermatology and Dermatopathology, Nippon Medical School Musashi
      Kosugi Hospital, Kawasaki City, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
SB  - IM
MH  - Breast Neoplasms/*diagnosis/pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Sebaceous Gland Neoplasms/classification/diagnosis/*pathology
MH  - Skin Neoplasms/diagnosis/secondary
MH  - Sweat Gland Neoplasms/diagnosis/*pathology
MH  - Sweat Glands/metabolism/*pathology
OTO - NOTNLM
OT  - borderline sebaceous neoplasm
OT  - immunohistochemistry
OT  - poroid neoplasm
OT  - sebaceous tumor
OT  - sweat gland tumor
EDAT- 2017/03/04 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/03/04 06:00
PHST- 2016/07/10 [received]
PHST- 2016/07/13 [accepted]
AID - 10.1111/1346-8138.13555 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555.

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