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Alterations in Tear Biochemistry Associated with Postanesthetic Chronic Dry Eye Syndrome.

Abstract Perioperative dry eye syndrome (DES) is a common ocular complication of long-term general anesthesia. Chronic DES can lead to permanent damage to the cornea and disturbance of visual function, up to total loss of vision. Here, a relationship between the duration of general anesthesia and the risk of chronic DES in patients was demonstrated. Using an experimental model of perioperative corneal abrasions in rabbits, it was found that introduction of animals to 3-h general anesthesia resulted in clinically significant chronic damage to the cornea in 50% of cases. The development of the complication was not associated with irreversible or long-term impairment of tear secretion, but it was accompanied by a decrease in tear film stability and growth of the total protein content as well as decrease in total antioxidant activity of the tear induced by low molecular weight antioxidants. In addition, anesthesia-induced changes in activity of tear antioxidant enzymes including superoxide dismutase and enzymes providing homeostasis of reduced glutathione (glutathione peroxidase, glutathione-S-transferase, glutathione reductase) were observed. All these alterations were protracted (up to 1-2 weeks) and therefore might account for transition of the perioperative DES into the chronic form. These findings can be useful in the development of novel approaches for the prevention and treatment of chronic forms of DES in the postanesthetic period.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title biochemistry. biokhimiia
Publication Year Start




PMID- 28259132
OWN - NLM
STAT- MEDLINE
DA  - 20170305
DCOM- 20170314
LR  - 20170314
IS  - 1608-3040 (Electronic)
IS  - 0006-2979 (Linking)
VI  - 81
IP  - 12
DP  - 2016 Dec
TI  - Alterations in Tear Biochemistry Associated with Postanesthetic Chronic Dry Eye
      Syndrome.
PG  - 1549-1557
LID - 10.1134/S0006297916120166 [doi]
AB  - Perioperative dry eye syndrome (DES) is a common ocular complication of long-term
      general anesthesia. Chronic DES can lead to permanent damage to the cornea and
      disturbance of visual function, up to total loss of vision. Here, a relationship 
      between the duration of general anesthesia and the risk of chronic DES in
      patients was demonstrated. Using an experimental model of perioperative corneal
      abrasions in rabbits, it was found that introduction of animals to 3-h general
      anesthesia resulted in clinically significant chronic damage to the cornea in 50%
      of cases. The development of the complication was not associated with
      irreversible or long-term impairment of tear secretion, but it was accompanied by
      a decrease in tear film stability and growth of the total protein content as well
      as decrease in total antioxidant activity of the tear induced by low molecular
      weight antioxidants. In addition, anesthesia-induced changes in activity of tear 
      antioxidant enzymes including superoxide dismutase and enzymes providing
      homeostasis of reduced glutathione (glutathione peroxidase,
      glutathione-S-transferase, glutathione reductase) were observed. All these
      alterations were protracted (up to 1-2 weeks) and therefore might account for
      transition of the perioperative DES into the chronic form. These findings can be 
      useful in the development of novel approaches for the prevention and treatment of
      chronic forms of DES in the postanesthetic period.
FAU - Zernii, E Yu
AU  - Zernii EY
AD  - Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical
      Biology, Moscow, 119991, Russia. [email protected]
FAU - Golovastova, M O
AU  - Golovastova MO
FAU - Baksheeva, V E
AU  - Baksheeva VE
FAU - Kabanova, E I
AU  - Kabanova EI
FAU - Ishutina, I E
AU  - Ishutina IE
FAU - Gancharova, O S
AU  - Gancharova OS
FAU - Gusev, A E
AU  - Gusev AE
FAU - Savchenko, M S
AU  - Savchenko MS
FAU - Loboda, A P
AU  - Loboda AP
FAU - Sotnikova, L F
AU  - Sotnikova LF
FAU - Zamyatnin, A A Jr
AU  - Zamyatnin AA Jr
FAU - Philippov, P P
AU  - Philippov PP
FAU - Senin, I I
AU  - Senin II
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochemistry (Mosc)
JT  - Biochemistry. Biokhimiia
JID - 0376536
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/*adverse effects
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Dry Eye Syndromes/*enzymology/etiology
MH  - Female
MH  - Glutathione Peroxidase/metabolism/secretion
MH  - Glutathione Reductase/metabolism/secretion
MH  - Glutathione Transferase/metabolism/secretion
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rabbits
MH  - Superoxide Dismutase/metabolism/secretion
MH  - Tears/enzymology/*secretion
EDAT- 2017/03/06 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/06 06:00
AID - BCM81129997 [pii]
AID - 10.1134/S0006297916120166 [doi]
PST - ppublish
SO  - Biochemistry (Mosc). 2016 Dec;81(12):1549-1557. doi: 10.1134/S0006297916120166.

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