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Therapeutic effects of different doses of polyethylene glycosylated porcine glucagon-like peptide-2 on ulcerative colitis in male rats.

Abstract Polyethylene glycosylated (PEGylated) porcine glucagon-like peptide-2 (pGLP-2) considerably increases half-life and stability compared with the native pGLP-2, but the effective dose for intestinal damage is still unclear. This study aims to evaluate the available dose of polyethylene glycosylated porcine glucagon-like peptide-2 (PEG-pGLP-2), a modified, long-acting form of pGLP-2 in an experimental rat model of ulcerative colitis.
PMID
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Authors

Mayor MeshTerms
Keywords

Inflammation cytokines

Porcine glucagon-like peptide-2

Tight junction

Ulcerative colitis

Journal Title bmc gastroenterology
Publication Year Start




PMID- 28259136
OWN - NLM
STAT- MEDLINE
DA  - 20170305
DCOM- 20170310
LR  - 20170310
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 04
TI  - Therapeutic effects of different doses of polyethylene glycosylated porcine
      glucagon-like peptide-2 on ulcerative colitis in male rats.
PG  - 34
LID - 10.1186/s12876-017-0593-x [doi]
AB  - BACKGROUND: Polyethylene glycosylated (PEGylated) porcine glucagon-like peptide-2
      (pGLP-2) considerably increases half-life and stability compared with the native 
      pGLP-2, but the effective dose for intestinal damage is still unclear. This study
      aims to evaluate the available dose of polyethylene glycosylated porcine
      glucagon-like peptide-2 (PEG-pGLP-2), a modified, long-acting form of pGLP-2 in
      an experimental rat model of ulcerative colitis. METHODS: Thirty-five male rats
      were randomly assigned into five groups: control, dextran sodium sulphate (DSS), 
      DSS + PEG-pGLP-2(L), DSS + PEG-pGLP-2(M) and DSS + PEG-pGLP-2(H). Rats in control
      group received only water; other rats were fed with 5% (w/v) DSS and
      intraperitoneally administered with 12.5, 25 and 100 nmol/kg PEG-pGLP-2 daily for
      6 days. RESULTS: Compared with the control treatment, DSS treatment significantly
      (p < 0.05) decreased body weight change, colonic length, duodenal villus height
      and expression of zonula occludens-1, whereas significantly (p < 0.05) increased 
      colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7,
      IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon. However,
      the three doses of PEG-pGLP-2 all reduced these effects; these treatments
      significantly (p < 0.05) increased body weight change and duodenal villus height,
      whereas significantly (p < 0.05) decreased colonic damage score and expression of
      IL-1, IL-7 and TNF-alpha in colon. Specifically, low-dose (12.5 nmol/kg/d)
      PEG-pGLP-2 was effective. CONCLUSIONS: These results indicated that PEG-pGLP-2 is
      a novel and potentially effective therapy for intestinal healing in a relatively 
      low dose.
FAU - Qi, Ke-Ke
AU  - Qi KK
AD  - Institute of Animal Science, Zhejiang Academy of Agricultural Sciences, 198
      Shiqiao Road, Jianggan, Hangzhou, 310021, China.
FAU - Lv, Jia-Jia
AU  - Lv JJ
AD  - Institute of Animal Science, Zhejiang Academy of Agricultural Sciences, 198
      Shiqiao Road, Jianggan, Hangzhou, 310021, China.
FAU - Wu, Jie
AU  - Wu J
AD  - Institute of Animal Science, Zhejiang Academy of Agricultural Sciences, 198
      Shiqiao Road, Jianggan, Hangzhou, 310021, China.
FAU - Xu, Zi-Wei
AU  - Xu ZW
AD  - Institute of Animal Science, Zhejiang Academy of Agricultural Sciences, 198
      Shiqiao Road, Jianggan, Hangzhou, 310021, China. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170304
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Claudin-1)
RN  - 0 (Cytokines)
RN  - 0 (Glucagon-Like Peptide 2)
RN  - 0 (Zonula Occludens-1 Protein)
RN  - 30IQX730WE (Polyethylene Glycols)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Claudin-1/drug effects
MH  - Colitis, Ulcerative/chemically induced/*drug therapy
MH  - Colon/*drug effects
MH  - Cytokines/drug effects
MH  - Dextran Sulfate
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Duodenum/drug effects
MH  - Glucagon-Like Peptide 2/*administration & dosage
MH  - Intestinal Mucosa/*drug effects
MH  - Male
MH  - Polyethylene Glycols/*administration & dosage
MH  - Rats
MH  - Zonula Occludens-1 Protein/drug effects
PMC - PMC5336612
OTO - NOTNLM
OT  - Inflammation cytokines
OT  - Porcine glucagon-like peptide-2
OT  - Tight junction
OT  - Ulcerative colitis
EDAT- 2017/03/06 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/03/06 06:00
PHST- 2016/12/23 [received]
PHST- 2017/03/01 [accepted]
AID - 10.1186/s12876-017-0593-x [doi]
AID - 10.1186/s12876-017-0593-x [pii]
PST - epublish
SO  - BMC Gastroenterol. 2017 Mar 4;17(1):34. doi: 10.1186/s12876-017-0593-x.

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