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Melanomas of the vulva and vagina.

Abstract Malignant melanoma is a rare type of cancer in the vagina and vulva associated with a poor prognosis due to late diagnosis and early dissemination. Only a limited amount of literature exists on the condition. This study elucidates the effect of current treatment.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title danish medical journal
Publication Year Start




PMID- 28260594
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170313
LR  - 20170313
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 64
IP  - 3
DP  - 2017 Mar
TI  - Melanomas of the vulva and vagina.
LID - A5336 [pii]
AB  - INTRODUCTION: Malignant melanoma is a rare type of cancer in the vagina and vulva
      associated with a poor prognosis due to late diagnosis and early dissemination.
      Only a limited amount of literature exists on the condition. This study
      elucidates the effect of current treatment. METHODS: All patients diagnosed with 
      malignant melanoma in the vagina or vulva at Aarhus University Hospital, Skejby, 
      Denmark, in the period from 1996 to 2013 were included. Data were collected from 
      the electronic patient records and from the Danish Pathology Register. RESULTS: A
      total of 17 patients were included. The average age at the time of diagnosis was 
      77 years and the median overall survival time was 21.9 months. The five-year
      survival in this study was 17.7%. The majority of the melanomas were nodular and 
      all of the superficially spreading melanomas were found in the vulva only.
      Malignant melanoma in the vagina has a poorer prognosis than in the vulva as it
      is diagnosed later. CONCLUSIONS: Early diagnosis and staging of this cancer is
      important. Positron emission tomography-computed tom-ography should be the
      standard method for staging the disease. Older women with vaginal discharge
      should always have a gynaecological examination. The primary treatment is
      resection of the tumour, but future treatment might be a combination of resection
      and immunotherapy. FUNDING: none. TRIAL REGISTRATION: not relevant. .
FAU - Skovsted, Sasia
AU  - Skovsted S
AD  - jab@dadlnet.dk.
FAU - Nielsen, Karsten
AU  - Nielsen K
FAU - Blaakaer, Jan
AU  - Blaakaer J
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Denmark
MH  - Female
MH  - Humans
MH  - Melanoma/mortality/pathology/*therapy
MH  - Middle Aged
MH  - Registries
MH  - Retrospective Studies
MH  - Vaginal Neoplasms/mortality/pathology/*therapy
MH  - Vulvar Neoplasms/mortality/pathology/*therapy
EDAT- 2017/03/07 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/07 06:00
AID - A5336 [pii]
PST - ppublish
SO  - Dan Med J. 2017 Mar;64(3). pii: A5336.

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