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A Danish nationwide questionnaire study of hepatitis B virus screening before immunosuppressive therapy.

Abstract Difficulty in identifying patients who are at risk for hepatitis B virus (HBV) reactivation makes it import-ant to screen for HBV before initiating immunosuppressive therapy. The aim of this study was to investigate screening procedures for HBV infection before initiation of immunosuppressive therapy and to explore HBV treatment strategies.
PMID
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Authors

Mayor MeshTerms

Secondary Prevention

Keywords
Journal Title danish medical journal
Publication Year Start




PMID- 28260595
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170313
LR  - 20170313
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 64
IP  - 3
DP  - 2017 Mar
TI  - A Danish nationwide questionnaire study of hepatitis B virus screening before
      immunosuppressive therapy.
LID - A5341 [pii]
AB  - INTRODUCTION: Difficulty in identifying patients who are at risk for hepatitis B 
      virus (HBV) reactivation makes it import-ant to screen for HBV before initiating 
      immunosuppressive therapy. The aim of this study was to investigate screening
      procedures for HBV infection before initiation of immunosuppressive therapy and
      to explore HBV treatment strategies. METHODS: All Danish units of haematology,
      oncology, dermatology, rheumatology and gastroenterology using immunosuppressive 
      agents were invited to fill out a questionnaire for The Danish Database for
      Hepatitis B and C. RESULTS: A total of 28 (53%) of the 53 included units answered
      the questionnaire, of which 25 (89.3%) had a guideline regarding screening for
      HBV serological markers prior to immunosuppressive therapy, but only ten (37%)
      had a guideline that is in line with the joint guidelines from the national
      Danish Societies of Infectious Diseases and Gastroenterology and Hepatology.
      Nineteen (76%) units had a strategy regarding treatment for reactivation before
      initiating immunosuppressive therapy in case of positive HBV serology. It was not
      possible to determine the number of HBV reactivations as this was not registered 
      in the ICD-10 system. The Danish Medicines Agency had one report of reactivation.
      CONCLUSIONS: A minority of the units had screening guidelines for HBV
      reactivation that were in line with the guidelines of the national scientific
      societies. Screening in accordance with these recommendations should be a goal
      for all Danish units in order to prevent HBV reactivation. FUNDING: none. TRIAL
      REGISTRATION: not relevant.
FAU - Bunyoz, Kristine Ifigenia
AU  - Bunyoz KI
AD  - [email protected]
FAU - Krarup, Henrik
AU  - Krarup H
FAU - Weis, Nina
AU  - Weis N
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Denmark
MH  - Hepatitis B/blood/*diagnosis/prevention & control
MH  - Hepatitis B virus/isolation & purification/physiology
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects
MH  - Mass Screening
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - *Secondary Prevention
MH  - Surveys and Questionnaires
MH  - Virus Activation
EDAT- 2017/03/07 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/07 06:00
AID - A5341 [pii]
PST - ppublish
SO  - Dan Med J. 2017 Mar;64(3). pii: A5341.

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