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Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate.

Abstract Background. Obesity and dietary habits are associated with increased incidences of aging-related prostatic diseases. The present study was aimed to investigate transgenerational effects of chronic high-fat diet (HFD) feeding on inflammation and senescence-related changes in prostate. Methods. Sprague-Dawley rats were kept on either normal or HFD one. Senescence-associated β-galactosidase (SA β-gal) activity, inflammation, and cellular proliferation were determined in the prostate. Results. Increased SA β-gal activity, expression of p53, and cell proliferation marker PCNA were observed in ventral prostate of HFD-fed rats. Immunostaining for p53 and PCNA revealed that the p53 immunopositive cells were primarily in stroma while PCNA immunopositive cells were epithelial cells. An increase in expression of cycloxygenase-2 (COX-2) and phosphorylation of nuclear factor-kappa B (NF-kB) was observed in prostate of weaning pups HFD-fed parents. However, in adult pups, irrespective of dietary habit, a significant increase in the expression of COX-2, PCNA, phosphorylation of NF-kB, infiltration of inflammatory cells, and SA β-gal activity was observed. Conclusions. Present investigation reports that HFD feeding promotes accumulation of p53 expressing cells, proliferation of epithelial cells, and senescence-related changes in prostate. Further, parental HFD-feeding upholds inflammatory, proliferative, and senescence-related changes in prostate of pups.
PMID
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Authors

Mayor MeshTerms

Cell Aging

Keywords
Journal Title oxidative medicine and cellular longevity
Publication Year Start




PMID- 28261375
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170313
LR  - 20170313
IS  - 1942-0994 (Electronic)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in
      Prostate.
PG  - 4962950
LID - 10.1155/2017/4962950 [doi]
AB  - Background. Obesity and dietary habits are associated with increased incidences
      of aging-related prostatic diseases. The present study was aimed to investigate
      transgenerational effects of chronic high-fat diet (HFD) feeding on inflammation 
      and senescence-related changes in prostate. Methods. Sprague-Dawley rats were
      kept on either normal or HFD one. Senescence-associated beta-galactosidase (SA
      beta-gal) activity, inflammation, and cellular proliferation were determined in
      the prostate. Results. Increased SA beta-gal activity, expression of p53, and
      cell proliferation marker PCNA were observed in ventral prostate of HFD-fed rats.
      Immunostaining for p53 and PCNA revealed that the p53 immunopositive cells were
      primarily in stroma while PCNA immunopositive cells were epithelial cells. An
      increase in expression of cycloxygenase-2 (COX-2) and phosphorylation of nuclear 
      factor-kappa B (NF-kB) was observed in prostate of weaning pups HFD-fed parents. 
      However, in adult pups, irrespective of dietary habit, a significant increase in 
      the expression of COX-2, PCNA, phosphorylation of NF-kB, infiltration of
      inflammatory cells, and SA beta-gal activity was observed. Conclusions. Present
      investigation reports that HFD feeding promotes accumulation of p53 expressing
      cells, proliferation of epithelial cells, and senescence-related changes in
      prostate. Further, parental HFD-feeding upholds inflammatory, proliferative, and 
      senescence-related changes in prostate of pups.
FAU - Tikoo, Kulbhushan
AU  - Tikoo K
AUID- ORCID: 0000-0003-3061-9739
AD  - Laboratory of Epigenetics and Diseases, Department of Pharmacology and
      Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), 
      Mohali, Punjab 160 062, India.
FAU - Vikram, Ajit
AU  - Vikram A
AUID- ORCID: 0000-0003-3724-3842
AD  - Facility for Risk Assessment and Intervention Studies, Department of Pharmacology
      and Toxicology, National Institute of Pharmaceutical Education and Research
      (NIPER), Mohali, Punjab 160 062, India.
FAU - Shrivastava, Shweta
AU  - Shrivastava S
AD  - Laboratory of Epigenetics and Diseases, Department of Pharmacology and
      Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), 
      Mohali, Punjab 160 062, India.
FAU - Jena, Gopabandhu
AU  - Jena G
AD  - Facility for Risk Assessment and Intervention Studies, Department of Pharmacology
      and Toxicology, National Institute of Pharmaceutical Education and Research
      (NIPER), Mohali, Punjab 160 062, India.
FAU - Shah, Heta
AU  - Shah H
AD  - Laboratory of Epigenetics and Diseases, Department of Pharmacology and
      Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), 
      Mohali, Punjab 160 062, India.
FAU - Chhabra, Richa
AU  - Chhabra R
AD  - Laboratory of Epigenetics and Diseases, Department of Pharmacology and
      Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), 
      Mohali, Punjab 160 062, India.
LA  - eng
PT  - Journal Article
DEP - 20170205
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
SB  - IM
MH  - Animals
MH  - *Cell Aging
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Immunoprecipitation
MH  - Inflammation/*etiology/pathology
MH  - Insulin Resistance
MH  - Male
MH  - Obesity/etiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - Prostate/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC5316447
COI - The authors declared no conflict of interests.
EDAT- 2017/03/07 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/09/09 [received]
PHST- 2016/11/24 [revised]
PHST- 2016/12/08 [accepted]
AID - 10.1155/2017/4962950 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:4962950. doi: 10.1155/2017/4962950. Epub 2017 Feb
      5.

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