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PMID- 28262033
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170316
LR  - 20170316
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Fatty acid composition and anticancer activity in colon carcinoma cell lines of
      Prunus dulcis seed oil.
PG  - 1239-1248
LID - 10.1080/13880209.2017.1296003 [doi]
AB  - CONTEXT: Almond oil is used in traditional and complementary therapies for its
      numerous health benefits due to high unsaturated fatty acids content. OBJECTIVES:
      This study investigated the composition and in vitro anticancer activity of
      almond oil from Northern Cyprus and compared with almond oil from Turkey.
      MATERIALS AND METHODS: Almond oil from Northern Cyprus was obtained by
      supercritical CO2 extraction and analyzed by GC-MS. Almond oil of Turkey was
      provided from Turkish pharmacies. Different concentrations of almond oils were
      incubated for 24 and 48 h with Colo-320 and Colo-741 cells. Cell growth and
      cytotoxicity were measured by MTT assays. Anticancer and antiprolifetarive
      activities of almond oils were investigated by immunocytochemistry using
      antibodies directed against to BMP-2, beta-catenin, Ki-67, LGR-5 and Jagged 1.
      RESULTS: Oleic acid (77.8%; 75.3%), linoleic acid (13.5%; 15.8%), palmitic acid
      (7.4%; 6.3%), were determined as the major compounds of almond oil from Northern 
      Cyprus and Turkey, respectively. In the MTT assay, both almond oils were found to
      be active against Colo-320 and Colo-741 cells with 1:1 dilution for both 24 h and
      48 h. As a result of immunohistochemical staining, while both almond oils
      exhibited significant antiproliferative and anticancer activity, these activities
      were more similar in Colo-320 cells which were treated with Northern Cyprus
      almond oil. DISCUSSION AND CONCLUSION: Almond oil from Northern Cyprus and Turkey
      may have anticancer and antiproliferative effects on colon cancer cells through
      molecular signalling pathways and, thus, they could be potential novel
      therapeutic agents.
FAU - Mericli, Filiz
AU  - Mericli F
AD  - a Department of Pharmacognosy-Phytotherapy, Faculty of Pharmacy , Near East
      University , Mersin , Turkey.
FAU - Becer, Eda
AU  - Becer E
AD  - b Department of Biochemistry, Faculty of Pharmacy , Near East University , Mersin
      , Turkey.
FAU - Kabadayi, Hilal
AU  - Kabadayi H
AD  - c Department of Histology and Embryology, Faculty of Medicine , Celal Bayar
      University , Manisa , Turkey.
FAU - Hanoglu, Azmi
AU  - Hanoglu A
AD  - d Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University
      , Mersin , Turkey.
FAU - Yigit Hanoglu, Duygu
AU  - Yigit Hanoglu D
AD  - d Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University
      , Mersin , Turkey.
FAU - Ozkum Yavuz, Dudu
AU  - Ozkum Yavuz D
AD  - d Department of Pharmaceutical Botany, Faculty of Pharmacy , Near East University
      , Mersin , Turkey.
FAU - Ozek, Temel
AU  - Ozek T
AD  - e Department of Pharmacognosy, Faculty of Pharmacy , Anadolu University ,
      Eskisehir , Turkey.
FAU - Vatansever, Seda
AU  - Vatansever S
AD  - c Department of Histology and Embryology, Faculty of Medicine , Celal Bayar
      University , Manisa , Turkey.
AD  - f Experimental Health Research Center of Health Sciences , Near East University ,
      Mersin , Turkey.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Fatty Acids)
RN  - 0 (Plant Oils)
RN  - 8007-69-0 (almond oil)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/isolation &
      purification/*pharmacology/therapeutic use
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects/physiology
MH  - Colonic Neoplasms/drug therapy/*pathology
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids/isolation & purification/*pharmacology/therapeutic use
MH  - Humans
MH  - Plant Oils/isolation & purification/*pharmacology/therapeutic use
MH  - *Prunus dulcis
MH  - *Seeds
OTO - NOTNLM
OT  - Almond oil
OT  - colo-320 cell line
OT  - colo-741 cell line
OT  - oleic acid
EDAT- 2017/03/07 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/07 06:00
AID - 10.1080/13880209.2017.1296003 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1239-1248. doi: 10.1080/13880209.2017.1296003.

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