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Kerato-lenticular ocular deposits and visual impairment with prolonged chlorpromazine use: A case series.

Abstract Chlorpromazine is a low potency "typical" antipsychotic agent used to treat schizophrenia. It continues to be prescribed frequently in India owing to its lower cost. There have been previous reports of ocular adverse effects with prolonged use of chlorpromazine. We report three patients who developed corneal and lenticular opacities secondary to prolonged chlorpromazine use leading to visual impairment. Early detection of ocular deposits and switching over to risperidone from chlorpromazine helped in the reversal of chlorpromazine- induced ocular side effects in one of them. The case series further adds evidence to the causative relationship between chlorpromazine and ocular side effects.
PMID
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Authors

Mayor MeshTerms
Keywords

Cataract

Chlorpromazine

Corneal deposits

Switch over

Visual impairment

Journal Title asian journal of psychiatry
Publication Year Start




PMID- 28262147
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170314
LR  - 20170314
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 25
DP  - 2017 Feb
TI  - Kerato-lenticular ocular deposits and visual impairment with prolonged
      chlorpromazine use: A case series.
PG  - 188-190
LID - S1876-2018(16)30382-3 [pii]
LID - 10.1016/j.ajp.2016.11.002 [doi]
AB  - Chlorpromazine is a low potency "typical" antipsychotic agent used to treat
      schizophrenia. It continues to be prescribed frequently in India owing to its
      lower cost. There have been previous reports of ocular adverse effects with
      prolonged use of chlorpromazine. We report three patients who developed corneal
      and lenticular opacities secondary to prolonged chlorpromazine use leading to
      visual impairment. Early detection of ocular deposits and switching over to
      risperidone from chlorpromazine helped in the reversal of chlorpromazine- induced
      ocular side effects in one of them. The case series further adds evidence to the 
      causative relationship between chlorpromazine and ocular side effects.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Gowda, Guru S
AU  - Gowda GS
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences
      (NIMHANS), Bangalore, 560029, India. Electronic address: drgsgowda@gmail.com.
FAU - Hegde, Aditya
AU  - Hegde A
AD  - Northwest Mental Health, Victoria, Australia.
FAU - Shanbhag, Vandita
AU  - Shanbhag V
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences
      (NIMHANS), Bangalore, 560029, India.
FAU - Narayanaswamy, Janardhanan C
AU  - Narayanaswamy JC
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences
      (NIMHANS), Bangalore, 560029, India.
FAU - Jaisoorya, T S
AU  - Jaisoorya TS
AD  - Department of Psychiatry, National Institute of Mental Health and Neurosciences
      (NIMHANS), Bangalore, 560029, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161111
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
RN  - 0 (Antipsychotic Agents)
RN  - U42B7VYA4P (Chlorpromazine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects
MH  - Cataract/*chemically induced
MH  - Chlorpromazine/*adverse effects
MH  - Cornea/pathology
MH  - Female
MH  - Humans
MH  - Lens Capsule, Crystalline/pathology
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/diet therapy/*drug therapy
MH  - Vision Disorders/*chemically induced
OTO - NOTNLM
OT  - *Cataract
OT  - *Chlorpromazine
OT  - *Corneal deposits
OT  - *Switch over
OT  - *Visual impairment
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/08/25 [received]
PHST- 2016/10/26 [revised]
PHST- 2016/11/06 [accepted]
AID - S1876-2018(16)30382-3 [pii]
AID - 10.1016/j.ajp.2016.11.002 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2017 Feb;25:188-190. doi: 10.1016/j.ajp.2016.11.002. Epub 2016
      Nov 11.

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